Lista de obras -

A phase II study of NK012, a polymeric micelle formulation of SN-38, in unresectable, metastatic or recurrent colorectal cancer patients

scientific article published on 04 October 2018

Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer

artículo científico publicado en 2014

Antitumor effect of NK012, a 7-ethyl-10-hydroxycamptothecin-incorporating polymeric micelle, on U87MG orthotopic glioblastoma in mice compared with irinotecan hydrochloride in combination with bevacizumab.

artículo científico publicado en 2010

Antitumor effect of antitissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts

artículo científico publicado en 2015

Antitumour activity of NK012, SN-38-incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour.

artículo científico publicado en 2009

Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer

artículo científico publicado en 2019

Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect

artículo científico publicado en 2014

Cancer Stromal Targeting Therapy

artículo científico publicado en 2017

Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue.

artículo científico publicado en 2011

Characterization of Antibody Products Obtained through Enzymatic and Nonenzymatic Glycosylation Reactions with a Glycan Oxazoline and Preparation of a Homogeneous Antibody-Drug Conjugate via Fc N-Glycan

scientific article published on 17 April 2019

Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin

scientific article published in Scientific Reports

Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells via mTOR activation through Akt-independent pathway.

artículo científico publicado en 2018

Comparison of the National Nutritional Survey in Japan estimated individual-based nutritional data and NIPPON DATA80 food frequency questionnaires

artículo científico publicado en 2010

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

artículo científico publicado en 2015

Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases.

artículo científico publicado en 2010

Development of ADCs Using Molecular Imaging

artículo científico publicado en 2017

Development of Antibody-Drug Conjugates Using DDS and Molecular Imaging.

artículo científico publicado en 2017

Development of polymeric micelles for targeting intractable cancers

artículo científico publicado en 2016

Discovery of an uncovered region in fibrin clots and its clinical significance.

artículo científico publicado en 2013

Distal promoter regions are responsible for differential regulation of human orosomucoid-1 and -2 gene expression and acute phase responses.

artículo científico publicado en 2014

Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts.

artículo científico publicado en 2016

Effect of combined treatment with the epirubicin-incorporating micelles (NC-6300) and 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) on a human gastric cancer model

artículo científico publicado en 2013

Enhanced antitumor effect of anti-tissue factor antibody-conjugated epirubicin-incorporating micelles in xenograft models.

artículo científico publicado en 2015

Evaluation of the antitumor mechanism of antibody-drug conjugates against tissue factor in stroma-rich allograft models

scientific article published on 29 August 2019

Feasibility study of the Fab fragment of a monoclonal antibody against tissue factor as a diagnostic tool

artículo científico publicado en 2015

Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test.

artículo científico publicado en 2013

General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation.

artículo científico

Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.

artículo científico publicado en 2012

Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis

artículo científico publicado en 2010

Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients

artículo científico publicado en 2009

High expression of miR-181c as a predictive marker of recurrence in stage II colorectal cancer.

scientific article published on 28 December 2016

Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.

artículo científico publicado en 2013

Imaging mass spectrometry for the precise design of antibody-drug conjugates.

artículo científico publicado en 2016

Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease.

artículo científico publicado en 2017

Influence of the dissociation rate constant on the intra-tumor distribution of antibody-drug conjugate against tissue factor

scientific article published on 12 June 2018

Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men.

artículo científico publicado en 2013

Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80.

artículo científico publicado en 2013

Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer.

artículo científico publicado en 2014

Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model

artículo científico publicado en 2017

NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin.

artículo científico publicado en 2013

Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody

scientific article published on 01 December 2018

New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots

artículo científico publicado en 2011

New molecular diagnosis and screening methods for colorectal cancer using fecal protein, DNA and RNA.

artículo científico publicado en 2013

Phase I study of NK105, a nanomicellar paclitaxel formulation, administered on a weekly schedule in patients with solid tumors.

artículo científico publicado en 2016

Preclinical efficacy of Sym004, novel anti-EGFR antibody mixture, in esophageal squamous cell carcinoma cell lines.

artículo científico publicado en 2017

Preparation and characterization of anti-tissue factor single-chain variable fragment antibody for cancer diagnosis.

artículo científico publicado en 2014

Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer.

scientific article published on 30 April 2014

Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer

scientific article published on 19 November 2018

Significant antitumor effect of an antibody against TMEM180, a new colorectal cancer-specific molecule

artículo científico publicado en 2019

Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer.

artículo científico publicado en 2010

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

artículo científico publicado en 2018

The drug discovery by nanomedicine and its clinical experience

artículo científico

The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody.

artículo científico publicado en 2011

The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution

artículo científico publicado en 2013

Topological analysis of TMEM180, a newly identified membrane protein that is highly expressed in colorectal cancer cells

artículo científico publicado en 2019

Tumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment.

artículo científico publicado en 2016

Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells.

artículo científico publicado en 2018

U3-1402, a Novel HER3-Targeting Antibody-Drug Conjugate, for the Treatment of Colorectal Cancer

scientific article published on 08 August 2019

Utility of epirubicin-incorporating micelles tagged with anti-tissue factor antibody clone with no anticoagulant effect.

artículo científico publicado en 2015

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.

artículo científico publicado en 2016

Lista de obras de

A phase II study of NK012, a polymeric micelle formulation of SN-38, in unresectable, metastatic or recurrent colorectal cancer patients

Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer

Antitumor effect of NK012, a 7-ethyl-10-hydroxycamptothecin-incorporating polymeric micelle, on U87MG orthotopic glioblastoma in mice compared with irinotecan hydrochloride in combination with bevacizumab.

Antitumor effect of antitissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts

Antitumour activity of NK012, SN-38-incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour.

Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer

Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect

Cancer Stromal Targeting Therapy

Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue.

Characterization of Antibody Products Obtained through Enzymatic and Nonenzymatic Glycosylation Reactions with a Glycan Oxazoline and Preparation of a Homogeneous Antibody-Drug Conjugate via Fc N-Glycan

Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin

Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells via mTOR activation through Akt-independent pathway.

Comparison of the National Nutritional Survey in Japan estimated individual-based nutritional data and NIPPON DATA80 food frequency questionnaires

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases.

Development of ADCs Using Molecular Imaging

Development of Antibody-Drug Conjugates Using DDS and Molecular Imaging.

Development of polymeric micelles for targeting intractable cancers

Discovery of an uncovered region in fibrin clots and its clinical significance.

Distal promoter regions are responsible for differential regulation of human orosomucoid-1 and -2 gene expression and acute phase responses.

Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts.

Effect of combined treatment with the epirubicin-incorporating micelles (NC-6300) and 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) on a human gastric cancer model

Enhanced antitumor effect of anti-tissue factor antibody-conjugated epirubicin-incorporating micelles in xenograft models.

Evaluation of the antitumor mechanism of antibody-drug conjugates against tissue factor in stroma-rich allograft models

Feasibility study of the Fab fragment of a monoclonal antibody against tissue factor as a diagnostic tool

Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test.

General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation.

Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.

Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis

Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients

High expression of miR-181c as a predictive marker of recurrence in stage II colorectal cancer.

Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.

Imaging mass spectrometry for the precise design of antibody-drug conjugates.

Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease.

Influence of the dissociation rate constant on the intra-tumor distribution of antibody-drug conjugate against tissue factor

Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men.

Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80.

Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer.

Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model

NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin.

Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody

New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots

New molecular diagnosis and screening methods for colorectal cancer using fecal protein, DNA and RNA.

Phase I study of NK105, a nanomicellar paclitaxel formulation, administered on a weekly schedule in patients with solid tumors.

Preclinical efficacy of Sym004, novel anti-EGFR antibody mixture, in esophageal squamous cell carcinoma cell lines.

Preparation and characterization of anti-tissue factor single-chain variable fragment antibody for cancer diagnosis.

Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer.

Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer

Significant antitumor effect of an antibody against TMEM180, a new colorectal cancer-specific molecule

Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer.

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

The drug discovery by nanomedicine and its clinical experience

The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody.

The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution

Topological analysis of TMEM180, a newly identified membrane protein that is highly expressed in colorectal cancer cells

Tumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment.

Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells.

U3-1402, a Novel HER3-Targeting Antibody-Drug Conjugate, for the Treatment of Colorectal Cancer

Utility of epirubicin-incorporating micelles tagged with anti-tissue factor antibody clone with no anticoagulant effect.

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.