Lista de obras - M. Helena Vasconcelos - Dominio Público Uruguay

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.

artículo científico publicado en 2014

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.

artículo científico publicado en 2016

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis

artículo científico publicado en 2018

Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells.

artículo científico publicado en 2012

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

artículo científico publicado en 2011

Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness.

artículo científico publicado en 2015

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

artículo científico publicado en 2018

Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption

Biological properties of extracellular vesicles and their physiological functions.

artículo científico publicado en 2015

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Can Suillus granulatus (L.) Roussel be classified as a functional food?

artículo científico publicado en 2014

Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds

artículo científico publicado en 2016

Chemical composition of wild edible mushrooms and antioxidant properties of their water soluble polysaccharidic and ethanolic fractions

article

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

artículo científico publicado en 2014

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

artículo científico publicado en 2011

Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21.

artículo científico publicado en 2015

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives

artículo científico publicado en 2016

Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells.

artículo científico publicado en 2016

Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts

artículo científico publicado en 2020

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.

artículo científico publicado en 2011

Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts

artículo científico publicado en 1999

Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle

artículo científico publicado en 2010

Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile

artículo científico publicado en 2019

Evidence for a specific intracellular localization of an antisense oligonucleotide in k562 cells.

artículo científico publicado en 2005

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

artículo científico publicado en 2016

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

scientific article published on 15 October 2019

Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line

scholarly article in Industrial Crops and Products, vol. 59, August 2014

Functional foods based on extracts or compounds derived from mushrooms

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

scientific article published on 17 March 2017

Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone.

artículo científico publicado en 2010

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

artículo científico

Leccinum molle (Bon) Bon and Leccinum vulpinum Watling: The First Study of Their Nutritional and Antioxidant Potential.

artículo científico publicado en 2016

Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line

artículo científico publicado en 2016

Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis

scientific article published on 01 June 2018

Metal- and tissue-dependent relationship between metallothionein mRNA and protein.

artículo científico publicado en 2002

Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.

artículo científico publicado en 2015

MicroRNA regulation of core apoptosis pathways in cancer.

scientific article published on 08 December 2010

MicroRNAs in Cancer Drug Resistance and Drug Sensitivity

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells.

artículo científico publicado en 2016

Multidimensional optimization of promising antitumor xanthone derivatives.

artículo científico publicado en 2013

Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells

artículo científico publicado en 2015

New Uses for Old Drugs: Pharmacophore‐Based Screening for the Discovery of P‐Glycoprotein Inhibitors ⬇️

artículo científico publicado el 29 de marzo de 2011

New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death.

artículo científico publicado en 2013

Phenolic profile of seventeen Portuguese wild mushrooms

article

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays

artículo científico publicado en 2014

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

artículo científico publicado en 2020

Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis.

artículo científico publicado en 2011

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.

artículo científico publicado en 2009

Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models

artículo científico publicado en 2013

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis

artículo científico publicado en 2016

Special Issue: New Approaches to Counteract Drug Resistance in Cancer.

artículo científico publicado en 2016

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

artículo científico publicado en 2004

Structure and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective ⬇️

artículo científico publicado el 1 de enero de 2012

Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase

artículo científico publicado en 2014

Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line

Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line

Sulfated small molecules targeting eBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA.

artículo científico publicado en 2013

Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel

artículo científico publicado en 2017

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.

artículo científico publicado en 2018

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis.

artículo científico publicado en 2010

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

artículo científico publicado en 2019

Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells.

artículo científico publicado en 2013

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization

artículo científico publicado en 2018

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

scientific article published on 06 May 2020

The multi-factorial nature of clinical multidrug resistance in cancer

artículo científico publicado en 2019

The network of P-glycoprotein and microRNAs interactions

artículo científico publicado en 2013

Therapy-induced enrichment of putative lung cancer stem-like cells.

artículo científico

Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

artículo científico

Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles

artículo científico publicado en 2020

Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines.

artículo científico publicado en 2010

An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells

artículo científico publicado en 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de M. Helena Vasconcelos

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis

Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells.

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness.

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption

Biological properties of extracellular vesicles and their physiological functions.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

Can Suillus granulatus (L.) Roussel be classified as a functional food?

Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds

Chemical composition of wild edible mushrooms and antioxidant properties of their water soluble polysaccharidic and ethanolic fractions

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21.

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives

Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells.

Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.

Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts

Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle

Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile

Evidence for a specific intracellular localization of an antisense oligonucleotide in k562 cells.

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line

Functional foods based on extracts or compounds derived from mushrooms

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone.

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

Leccinum molle (Bon) Bon and Leccinum vulpinum Watling: The First Study of Their Nutritional and Antioxidant Potential.

Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line

Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis

Metal- and tissue-dependent relationship between metallothionein mRNA and protein.

Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.

MicroRNA regulation of core apoptosis pathways in cancer.

MicroRNAs in Cancer Drug Resistance and Drug Sensitivity

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells.

Multidimensional optimization of promising antitumor xanthone derivatives.

Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells

New Uses for Old Drugs: Pharmacophore‐Based Screening for the Discovery of P‐Glycoprotein Inhibitors ⬇️

New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death.

Phenolic profile of seventeen Portuguese wild mushrooms

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis.

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.

Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis

Special Issue: New Approaches to Counteract Drug Resistance in Cancer.

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

Structure and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective ⬇️

Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase

Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line

Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line

Sulfated small molecules targeting eBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA.

Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis.

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells.

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

The multi-factorial nature of clinical multidrug resistance in cancer

The network of P-glycoprotein and microRNAs interactions

Therapy-induced enrichment of putative lung cancer stem-like cells.

Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles

Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines.

An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)