Lista de obras - Alain Couvineau - Dominio Público Uruguay

A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.

artículo científico publicado en 1995

Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia ⬇️

artículo científico publicado el 1 de julio de 1998

Alanine scanning of VIP. Structure-function relationship for binding to human recombinant VPAC1 receptor

artículo científico publicado en 2000

Antisecretory Effects of Chimeric Somatostatin/Dopamine Receptor Ligands on Gastroenteropancreatic Neuroendocrine Tumors

artículo científico publicado en 2017

Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production

scientific article published on 01 January 1997

Biological and structural analysis of truncated analogs of PACAP27.

artículo científico publicado en 2008

Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa

artículo científico publicado en 1993

Characterization of a common VIP-PACAP receptor in human small intestinal epithelium

scientific article published on 01 February 1993

Characterization of the new photoaffinity probe (Bz2-K24)-VIP.

artículo científico publicado en 2006

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.

artículo científico publicado en 2015

Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology.

artículo científico publicado en 2007

Class-B GPCR activation: is ligand helix-capping the key?

artículo científico publicado en 2008

Cloning and functional characterization of the human VIP1/PACAP receptor promoter.

artículo científico publicado en 1998

Constitutive activation of the human VIP1 receptor

scientific article published on 01 December 1998

Constitutive activation of the human vasoactive intestinal peptide 1 receptor, a member of the new class II family of G protein-coupled receptors

scientific article published on 01 February 1998

Construction of chimeras between human VIP1 and secretin receptors: identification of receptor domains involved in selectivity towards VIP, secretin, and PACAP

artículo científico publicado en 1998

Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIP.

artículo científico publicado en 2004

Dipeptidyl peptidase IV expression in rat jejunal crypt-villus axis is controlled at mRNA level ⬇️

artículo científico publicado el 1 de noviembre de 1991

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis.

artículo científico publicado en 2009

Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A

scientific article published on 18 August 2018

Establishment of a CHO cell clone stably expressing the recombinant human VIP-1 receptor

artículo científico publicado en 1996

Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat.

artículo científico publicado en 2006

Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex

artículo científico publicado en 2015

Functional and immunological evidence for stable association of solubilized vasoactive-intestinal-peptide receptor and stimulatory guanine-nucleotide-binding protein from rat liver

artículo científico publicado en 1990

G proteins in rat liver proliferation during cholestasis

scientific article published on 01 October 1994

Glycosylation of VIP receptors: a molecular basis for receptor heterogeneity.

artículo científico publicado en 1993

Gs and Gi protein subunits during cell differentiation in intestinal crypt-villus axis: regulation at the mRNA level.

artículo científico publicado en 1992

Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP.

artículo científico publicado en 2010

Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.

artículo científico publicado en 2003

Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide

artículo científico publicado en 2000

Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice

artículo científico publicado en 2017

In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

artículo científico publicado en 2018

Interaction of PHM, PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium: comparison with rat intestinal receptors.

artículo científico publicado en 1985

Intestinal cell targeting of a stable recombinant Cu–Zn SOD from Cucumis melo fused to a gliadin peptide ⬇️

artículo científico publicado el 7 de marzo de 2012

Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge

artículo científico publicado en 2007

Localization and Processing of Glycosylphosphatidylinositol-Anchored Cathepsin D

artículo científico publicado en 1995

Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP

artículo científico publicado en 2002

Mutagenesis of N-glycosylation sites in the human VIP 1 receptor

scientific article published on 01 December 1996

Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding.

artículo científico publicado en 1995

Neurotensin Receptor and Its mRNA Are Expressed in Many Human Colon Cancer Cell Lines But Not in Normal Colonic Epithelium: Binding Studies and RT-PCR Experiments ⬇️

artículo científico publicado el 30 de agosto de 1994

Novel receptor partners and function of receptor activity-modifying proteins

artículo científico publicado en 2003

Obesity-induced pancreatopathy in rats is reversible after bariatric surgery

artículo científico publicado en 2018

PTHR1 mutations associated with Ollier disease result in receptor loss of function

artículo científico publicado en 2008

Presence of a N-terminal signal peptide in class II G protein-coupled receptors: crucial role for expression of the human VPAC1 receptor.

artículo científico publicado en 2004

Purification of a galanin receptor from pig brain.

artículo científico publicado en 1993

Purification of vasoactive intestinal peptide receptor from porcine liver by a newly designed one-step affinity chromatography

artículo científico publicado en 1990

Receptors for gut regulatory peptides.

artículo científico publicado en 1994

Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance

artículo científico publicado en 2011

Regional expression of epithelial dipeptidyl peptidase IV in the human intestines

scientific article published on 01 September 1994

Role of cysteine residues in the N-terminal extracellular domain of the human VIP 1 receptor for ligand binding. A site-directed mutagenesis study

scientific article published on 01 December 1996

Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.

artículo científico publicado en 2003

Site-directed mutagenesis of human VIP1 versus VIP2 receptors

scientific article published on 01 December 1998

Site-directed mutagenesis of human vasoactive intestinal peptide receptor subtypes VIP1 and VIP2: evidence for difference in the structure-function relationship ⬇️

artículo científico publicado el 1 de febrero de 1998

Solubilization and hydrodynamic characterization of guanine nucleotide sensitive vasoactive intestinal peptide-receptor complexes from rat intestine

artículo científico publicado en 1989

Solubilization and hydrodynamic properties of active peptide YY receptor from rat jejunal crypts. Characterization as a Mr 44,000 glycoprotein

artículo científico publicado en 1991

Solubilization of active and stable receptors for vasoactive intestinal peptide from rat liver

scientific article published on 01 April 1989

Solubilization of the liver vasoactive intestinal peptide receptor. Hydrodynamic characterization and evidence for an association with a functional GTP regulatory protein

scientific article published on 01 November 1986

Spatial approximation between the C-terminus of VIP and the N-terminal ectodomain of the VPAC1 receptor.

artículo científico publicado en 2006

Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction ⬇️

artículo científico publicado el 30 de enero de 2012

Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.

artículo científico publicado en 1996

Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons.

artículo científico publicado en 2015

Structural requirements for VIP interaction with specific receptors in human and rat intestinal membranes: effect of nine partial sequences

scientific article published on 01 June 1984

Study of species specificity in growth hormone-releasing factor (GRF) interaction with vasoactive intestinal peptide (VIP) receptors using GRF and intestinal VIP receptors from rat and human: evidence that Ac-Tyr1hGRF is a competitive VIP antagonist

artículo científico publicado en 1986

Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays.

artículo científico publicado en 2010

Synthesis of a hydrophilic affinity matrix for the purification of the vasoactive intestinal peptide receptor

artículo científico publicado en 1993

The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role

scientific article published on 27 September 2018

The GIP receptor on pancreatic beta cell tumor: molecular identification by covalent cross-linking

artículo científico publicado en 1984

The N-terminal parts of VIP and antagonist PG97-269 physically interact with different regions of the human VPAC1 receptor.

artículo científico publicado en 2008

The VPAC1 receptor: structure and function of a class B GPCR prototype.

artículo científico publicado en 2012

The human VPAC1 receptor: identification of the N-terminal ectodomain as a major VIP-binding site by photoaffinity labeling and 3D modeling

artículo científico publicado en 2006

The human vasoactive intestinal Peptide/Pituitary adenylate cyclase activating peptide receptor 1 (VPAC1): constitutive activation by mutations at threonine 343

artículo científico publicado en 1999

The human vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor 1 (VPAC1) promoter: characterization and role in receptor expression during enterocytic differentiation of the colon cancer cell line Caco-2Cl.20

artículo científico publicado en 2000

The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis

artículo científico publicado en 2014

The rat liver vasoactive intestinal peptide binding site. Molecular characterization by covalent cross-linking and evidence for differences from the intestinal receptor.

artículo científico publicado en 1985

The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics

artículo científico publicado en 2007

Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

artículo científico publicado en 2016

VIP receptors from porcine liver: High yield solubilization in a GTP-insensitive form ⬇️

artículo científico publicado el 1 de enero de 1991

VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins

artículo científico publicado en 2012

Vasoactive intestinal peptide (VIP)1 receptor. Three nonadjacent amino acids are responsible for species selectivity with respect to recognition of peptide histidine isoleucineamide.

artículo científico publicado en 1996

Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47phox phosphorylation pathway in monocytes.

artículo científico publicado en 2016

Vasoactive intestinal peptide receptors in rat liver after partial hepatectomy ⬇️

artículo científico publicado el 15 de julio de 1992

[Directed mutagenesis of human recombinant receptors of vasoactive intestinal peptide of VIP1 and VIP2 type. Difference in structure-activity relationship]

scientific article published on 01 January 1997

[Novel deglycosylation-independent roles for peptide N-glycanase]

artículo científico publicado en 2014

Lista de obras de Alain Couvineau

A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.

Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia ⬇️

Alanine scanning of VIP. Structure-function relationship for binding to human recombinant VPAC1 receptor

Antisecretory Effects of Chimeric Somatostatin/Dopamine Receptor Ligands on Gastroenteropancreatic Neuroendocrine Tumors

Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production

Biological and structural analysis of truncated analogs of PACAP27.

Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa

Characterization of a common VIP-PACAP receptor in human small intestinal epithelium

Characterization of the new photoaffinity probe (Bz2-K24)-VIP.

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.

Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology.

Class-B GPCR activation: is ligand helix-capping the key?

Cloning and functional characterization of the human VIP1/PACAP receptor promoter.

Constitutive activation of the human VIP1 receptor

Constitutive activation of the human vasoactive intestinal peptide 1 receptor, a member of the new class II family of G protein-coupled receptors

Construction of chimeras between human VIP1 and secretin receptors: identification of receptor domains involved in selectivity towards VIP, secretin, and PACAP

Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIP.

Dipeptidyl peptidase IV expression in rat jejunal crypt-villus axis is controlled at mRNA level ⬇️

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis.

Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A

Establishment of a CHO cell clone stably expressing the recombinant human VIP-1 receptor

Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat.

Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex

Functional and immunological evidence for stable association of solubilized vasoactive-intestinal-peptide receptor and stimulatory guanine-nucleotide-binding protein from rat liver

G proteins in rat liver proliferation during cholestasis

Glycosylation of VIP receptors: a molecular basis for receptor heterogeneity.

Gs and Gi protein subunits during cell differentiation in intestinal crypt-villus axis: regulation at the mRNA level.

Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP.

Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.

Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide

Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice

In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

Interaction of PHM, PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium: comparison with rat intestinal receptors.

Intestinal cell targeting of a stable recombinant Cu–Zn SOD from Cucumis melo fused to a gliadin peptide ⬇️

Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge

Localization and Processing of Glycosylphosphatidylinositol-Anchored Cathepsin D

Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP

Mutagenesis of N-glycosylation sites in the human VIP 1 receptor

Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding.

Neurotensin Receptor and Its mRNA Are Expressed in Many Human Colon Cancer Cell Lines But Not in Normal Colonic Epithelium: Binding Studies and RT-PCR Experiments ⬇️

Novel receptor partners and function of receptor activity-modifying proteins

Obesity-induced pancreatopathy in rats is reversible after bariatric surgery

PTHR1 mutations associated with Ollier disease result in receptor loss of function

Presence of a N-terminal signal peptide in class II G protein-coupled receptors: crucial role for expression of the human VPAC1 receptor.

Purification of a galanin receptor from pig brain.

Purification of vasoactive intestinal peptide receptor from porcine liver by a newly designed one-step affinity chromatography

Receptors for gut regulatory peptides.

Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance

Regional expression of epithelial dipeptidyl peptidase IV in the human intestines

Role of cysteine residues in the N-terminal extracellular domain of the human VIP 1 receptor for ligand binding. A site-directed mutagenesis study

Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.

Site-directed mutagenesis of human VIP1 versus VIP2 receptors

Site-directed mutagenesis of human vasoactive intestinal peptide receptor subtypes VIP1 and VIP2: evidence for difference in the structure-function relationship ⬇️

Solubilization and hydrodynamic characterization of guanine nucleotide sensitive vasoactive intestinal peptide-receptor complexes from rat intestine

Solubilization and hydrodynamic properties of active peptide YY receptor from rat jejunal crypts. Characterization as a Mr 44,000 glycoprotein

Solubilization of active and stable receptors for vasoactive intestinal peptide from rat liver

Solubilization of the liver vasoactive intestinal peptide receptor. Hydrodynamic characterization and evidence for an association with a functional GTP regulatory protein

Spatial approximation between the C-terminus of VIP and the N-terminal ectodomain of the VPAC1 receptor.

Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction ⬇️

Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.

Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons.

Structural requirements for VIP interaction with specific receptors in human and rat intestinal membranes: effect of nine partial sequences

Study of species specificity in growth hormone-releasing factor (GRF) interaction with vasoactive intestinal peptide (VIP) receptors using GRF and intestinal VIP receptors from rat and human: evidence that Ac-Tyr1hGRF is a competitive VIP antagonist

Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays.

Synthesis of a hydrophilic affinity matrix for the purification of the vasoactive intestinal peptide receptor

The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role

The GIP receptor on pancreatic beta cell tumor: molecular identification by covalent cross-linking

The N-terminal parts of VIP and antagonist PG97-269 physically interact with different regions of the human VPAC1 receptor.

The VPAC1 receptor: structure and function of a class B GPCR prototype.

The human VPAC1 receptor: identification of the N-terminal ectodomain as a major VIP-binding site by photoaffinity labeling and 3D modeling

The human vasoactive intestinal Peptide/Pituitary adenylate cyclase activating peptide receptor 1 (VPAC1): constitutive activation by mutations at threonine 343

The human vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor 1 (VPAC1) promoter: characterization and role in receptor expression during enterocytic differentiation of the colon cancer cell line Caco-2Cl.20

The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis

The rat liver vasoactive intestinal peptide binding site. Molecular characterization by covalent cross-linking and evidence for differences from the intestinal receptor.

The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics

Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

VIP receptors from porcine liver: High yield solubilization in a GTP-insensitive form ⬇️

VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins

Vasoactive intestinal peptide (VIP)1 receptor. Three nonadjacent amino acids are responsible for species selectivity with respect to recognition of peptide histidine isoleucineamide.