Lista de obras - Slawomir Filipek - Dominio Público Uruguay

A Gating Mechanism of the Serotonin 5-HT3 Receptor

artículo científico publicado en 2016

A Hybrid Approach to Structure and Function Modeling of G Protein-Coupled Receptors

artículo científico publicado en 2016

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

artículo científico publicado en 2004

A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor

artículo científico publicado en 2004

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

artículo científico publicado en 2005

A novel dominant D109A CRYAB mutation in a family with myofibrillar myopathy affects αB-crystallin structure.

artículo científico publicado en 2016

A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene.

artículo científico publicado en 2013

Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human αB-crystallin.

artículo científico publicado en 2013

Action of molecular switches in GPCRs--theoretical and experimental studies.

artículo científico publicado en 2012

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

artículo científico publicado en 2014

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

artículo científico publicado en 2021

Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.

artículo científico publicado en 2012

Amyloidogenic Properties of Short α-L-Glutamic Acid Oligomers

scientific article published on 18 September 2015

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

artículo científico publicado en 2014

Approaches for Differentiation and Interconverting GPCR Agonists and Antagonists

artículo científico publicado en 2018

Aquaporin-graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

artículo científico publicado en 2018

Arginine interactions with anatase TiO2 (100) surface and the perturbation of 49Ti NMR chemical shifts--a DFT investigation: relevance to Renu-Seeram bio solar cell

artículo científico publicado en 2010

Arrestin interaction with rhodopsin: conceptual models.

artículo científico publicado en 2006

Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene

artículo científico publicado en 2006

Bio-batteries and bio-fuel cells: leveraging on electronic charge transfer proteins.

scientific article published on March 2009

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

artículo científico publicado en 2002

Ca2+ -dependent regulation of phototransduction

artículo científico publicado en 2008

CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1.

artículo científico publicado en 2009

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

artículo científico publicado en 2002

Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies

artículo científico publicado en 2001

Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening

artículo científico publicado en 2012

Co-translational association of cell-free expressed membrane proteins with supplied lipid bilayers

artículo científico publicado en 2012

Computational approach for the assessment of inhibitory potency against beta-amyloid aggregation.

artículo científico publicado en 2016

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

artículo científico publicado en 2019

Cross-linked glucose oxidase clusters for biofuel cell anode catalysts

artículo científico publicado en 2013

Cryo-EM structure of the native rhodopsin dimer in nanodiscs

scientific article published on 09 August 2019

Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors.

artículo científico publicado en 2002

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

artículo científico

Detecting molecular interactions that stabilize native bovine rhodopsin

artículo científico publicado en 2006

Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes

scientific article published on 16 May 2019

Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes).

artículo científico publicado en 2004

ERK1/2 is dephosphorylated by a novel phosphatase – CacyBP/SIP ⬇️

artículo científico publicado el 24 de noviembre de 2010

Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene

artículo científico publicado en 2007

Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

artículo científico publicado en 2020

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

artículo científico publicado en 2003

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

artículo científico publicado en 2015

Exploring a new ligand binding site of G protein-coupled receptors

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

artículo científico publicado en 2007

Functional characterization of rhodopsin monomers and dimers in detergents

artículo científico publicado en 2004

G protein-coupled receptor rhodopsin: a prospectus

artículo científico publicado en 2002

G protein-coupled receptors--recent advances

artículo científico publicado en 2012

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.

artículo científico publicado en 2018

GPCRmd uncovers the dynamics of the 3D-GPCRome

scientific article published on 13 July 2020

Generation and characterization of a novel, permanently active S100P mutant

artículo científico publicado en 2008

Genetic aspects of Alzheimer's disease.

artículo científico publicado en 2004

High-level cell-free production of membrane proteins with nanodiscs.

artículo científico publicado en 2014

Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor

artículo científico publicado en 2016

Identification of Specific Effect of Chloride on the Spectral Properties and Structural Stability of Multiple Extracellular Glutamic Acid Mutants of Bacteriorhodopsin

artículo científico publicado en 2016

Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23.

artículo científico publicado en 2017

Is rhodopsin dimeric in native retinal rods?

artículo científico publicado en 2003

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin

artículo científico publicado en 2003

Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.

artículo científico publicado en 2006

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations

artículo científico publicado en 2013

Low-temperature molecular dynamics simulations of horse heart cytochrome c and comparison with inelastic neutron scattering data.

artículo científico publicado en 2012

Lyotropic Cubic Phases for Drug Delivery: Diffusion and Sustained Release from the Mesophase Evaluated by Electrochemical Methods.

artículo científico publicado en 2015

Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein

artículo científico publicado en 2001

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

artículo científico publicado en 2016

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.

artículo científico publicado en 2011

Modulation of molecular interactions and function by rhodopsin palmitylation

artículo científico publicado en 2009

Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery

artículo científico publicado en 2021

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

artículo científico publicado en 2001

Molecular effects of encapsulation of glucose oxidase dimer by graphene

scholarly article in RSC Advances, vol. 5 no. 18, 2015

Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs.

artículo científico publicado en 2008

Molecular switches in GPCRs

scientific article published on 01 April 2019

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives

artículo científico publicado en 2015

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

artículo científico publicado en 2010

Non-peptide ligand binding to the formyl peptide receptor FPR2--A comparison to peptide ligand binding modes.

artículo científico publicado en 2015

Oligomerization of G protein-coupled receptors: past, present, and future

artículo científico publicado en 2004

Organization of rhodopsin molecules in native membranes of rod cells--an old theoretical model compared to new experimental data

artículo científico publicado en 2005

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

artículo científico publicado en 2003

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

artículo científico publicado en 2003

Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.

artículo científico publicado en 2017

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

artículo científico publicado en 2017

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

artículo científico publicado en 2016

Protein-carbon nanotube sensors: single platform integrated micro clinical lab for monitoring blood analytes

artículo científico publicado en 2012

Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome

scientific article published on 23 July 2020

Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment

artículo científico publicado en 2006

PyMOL and Inkscape Bridge the Data and the Data Visualization

artículo científico publicado en 2016

Quaternary structures of opsin in live cells revealed by FRET spectrometry

artículo científico publicado en 2016

Recognition of the let-7g miRNA precursor by human Lin28B

artículo científico publicado en 2012

Rhodopsin dimers in native disc membranes

artículo científico publicado en 2003

Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice

artículo científico publicado en 2004

Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function

artículo científico publicado en 2011

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

artículo científico publicado en 2003

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

artículo científico publicado en 2003

Stabilizing effect of Zn2+ in native bovine rhodopsin

artículo científico publicado en 2007

Structural investigation of the C-terminal catalytic fragment of presenilin 1

artículo científico publicado en 2010

Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations.

artículo científico publicado en 2010

Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments.

artículo científico publicado en 2015

Study on the feasibility of bacteriorhodopsin as bio-photosensitizer in excitonic solar cell: a first report.

artículo científico publicado en 2009

Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents.

artículo científico publicado en 2013

The G protein-coupled receptor rhodopsin in the native membrane

artículo científico publicado en 2004

The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations

scientific article published on 21 April 2020

The Molecular Mechanism of P2Y1 Receptor Activation

artículo científico publicado en 2016

The Principles of Ligand Specificity on beta-2-adrenergic receptor

artículo científico publicado en 2016

The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex

artículo científico publicado en 2021

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors

artículo científico publicado en 2003

The effect of triple glutamic mutations E9Q/E194Q/E204Q on the structural stability of bacteriorhodopsin

artículo científico publicado en 2014

The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors.

artículo científico publicado en 2015

The role of water and sodium ions in the activation of the μ-opioid receptor

artículo científico publicado en 2013

The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations

artículo científico publicado en 2012

The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes

artículo científico publicado en 2004

Towards improved quality of GPCR models by usage of multiple templates and profile-profile comparison

artículo científico publicado en 2013

Two desmin gene mutations associated with myofibrillar myopathies in Polish families

artículo científico publicado en 2014

Two novel presenilin 1 gene mutations connected with frontotemporal dementia-like clinical phenotype: Genetic and bioinformatic assessment

artículo científico publicado en 2006

Ubiquitous amyloids

artículo científico publicado en 2012

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

artículo científico publicado en 2008

Understanding the inhibitory effect of highly potent and selective archazolides binding to the vacuolar ATPase

artículo científico publicado en 2012

W246(6.48) opens a gate for a continuous intrinsic water pathway during activation of the adenosine A2A receptor

artículo científico publicado en 2014

alpha-asarone congeners as hypolipidemic agents. Pseudoreceptor versus minireceptor modeling

artículo científico publicado en 2000

Lista de obras de Slawomir Filipek

A Gating Mechanism of the Serotonin 5-HT3 Receptor

A Hybrid Approach to Structure and Function Modeling of G Protein-Coupled Receptors

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

A novel dominant D109A CRYAB mutation in a family with myofibrillar myopathy affects αB-crystallin structure.

A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene.

Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human αB-crystallin.

Action of molecular switches in GPCRs--theoretical and experimental studies.

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.

Amyloidogenic Properties of Short α-L-Glutamic Acid Oligomers

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

Approaches for Differentiation and Interconverting GPCR Agonists and Antagonists

Aquaporin-graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

Arginine interactions with anatase TiO2 (100) surface and the perturbation of 49Ti NMR chemical shifts--a DFT investigation: relevance to Renu-Seeram bio solar cell

Arrestin interaction with rhodopsin: conceptual models.

Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene

Bio-batteries and bio-fuel cells: leveraging on electronic charge transfer proteins.

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

Ca2+ -dependent regulation of phototransduction

CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1.

Calcium-binding proteins: intracellular sensors from the calmodulin superfamily

Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies

Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening

Co-translational association of cell-free expressed membrane proteins with supplied lipid bilayers

Computational approach for the assessment of inhibitory potency against beta-amyloid aggregation.

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Cross-linked glucose oxidase clusters for biofuel cell anode catalysts

Cryo-EM structure of the native rhodopsin dimer in nanodiscs

Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors.

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

Detecting molecular interactions that stabilize native bovine rhodopsin

Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes

Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes).

ERK1/2 is dephosphorylated by a novel phosphatase – CacyBP/SIP ⬇️

Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene

Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Exploring a new ligand binding site of G protein-coupled receptors

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

Functional characterization of rhodopsin monomers and dimers in detergents

G protein-coupled receptor rhodopsin: a prospectus

G protein-coupled receptors--recent advances

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.

GPCRmd uncovers the dynamics of the 3D-GPCRome

Generation and characterization of a novel, permanently active S100P mutant

Genetic aspects of Alzheimer's disease.

High-level cell-free production of membrane proteins with nanodiscs.

Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor

Identification of Specific Effect of Chloride on the Spectral Properties and Structural Stability of Multiple Extracellular Glutamic Acid Mutants of Bacteriorhodopsin

Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23.

Is rhodopsin dimeric in native retinal rods?

Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin

Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations

Low-temperature molecular dynamics simulations of horse heart cytochrome c and comparison with inelastic neutron scattering data.

Lyotropic Cubic Phases for Drug Delivery: Diffusion and Sustained Release from the Mesophase Evaluated by Electrochemical Methods.

Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.

Modulation of molecular interactions and function by rhodopsin palmitylation

Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

Molecular effects of encapsulation of glucose oxidase dimer by graphene

Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs.

Molecular switches in GPCRs

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

Non-peptide ligand binding to the formyl peptide receptor FPR2--A comparison to peptide ligand binding modes.

Oligomerization of G protein-coupled receptors: past, present, and future

Organization of rhodopsin molecules in native membranes of rod cells--an old theoretical model compared to new experimental data

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

Pharmacophore guided discovery of small-molecule interleukin 15 inhibitors.

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.