Lista de obras - Delphine Borgel - Dominio Público Uruguay

A Comparative Study of the Protein C Pathway in Septic and Nonseptic Patients with Organ Failure

artículo científico publicado en 2007

A capillary zone electrophoresis method to detect conformers and dimers of antithrombin in therapeutic preparations

artículo científico publicado en 2016

A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity.

artículo científico publicado en 2013

A fast capillary electrophoresis method to assess the binding affinity of recombinant antithrombin toward heparin directly from cell culture supernatants.

artículo científico publicado en 2015

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation

artículo científico publicado en 2017

A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

article

Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients

article

Activated protein C, a protein at the crossroads between coagulation and inflammation

artículo científico publicado en 2011

An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.

artículo científico publicado en 2018

Antithrombin is not protective against renal ischaemia-reperfusion injury

artículo científico publicado en 2016

Assessment of the interplay between blood and skin vascular abnormalities in adult purpura fulminans

artículo científico publicado en 2013

Characterization of cleaved plasma protein S with a monoclonal antibody-based assay

artículo científico publicado en 2000

Characterization of conformers and dimers of antithrombin by capillary electrophoresis-quadrupole-time-of-flight mass spectrometry

artículo científico publicado en 2016

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.

artículo científico publicado en 2016

Cleaved protein S (PS), total PS, free PS, and activated protein C cofactor activity as risk factors for venous thromboembolism

scientific article published on 01 April 2003

Clinical variability and probable founder effect in oculocutaneous albinism type 7

scientific article published on 06 November 2019

Clinical, laboratory and molecular findings and long-term follow-up data in 96 French patients with PMM2-CDG (phosphomannomutase 2-congenital disorder of glycosylation) and review of the literature.

artículo científico publicado en 2017

Coagulation phenotypes in septic shock as evaluated by calibrated automated thrombography

artículo científico publicado en 2015

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

artículo científico publicado en 2017

Connexin 37 limits thrombus propensity by downregulating platelet reactivity.

artículo científico publicado en 2011

Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure*

artículo científico publicado en 2007

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4

scientific article published on 26 July 2018

Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status.

artículo científico publicado en 2007

Development of a recombinant antithrombin variant as a potent antidote to fondaparinux and other heparin derivatives

article

Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis

artículo científico publicado en 2006

Elevated thrombin generation in patients with congenital disorder of glycosylation and combined coagulation factor deficiencies

scientific article published on 28 July 2019

Endothelial cell surface limits coagulation without modulating the antithrombin potency

artículo científico publicado en 2018

Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

artículo científico publicado en 2000

Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations

artículo científico publicado en 2003

First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484-->Pro, in the protein S active gene (PROS1)

article

First frameshift mutation in the active protein S gene associated with a quantitative hereditary deficiency

artículo científico publicado en 1994

Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report

artículo científico publicado en 2019

Functional properties of the sex-hormone-binding globulin (SHBG)-like domain of the anticoagulant protein S.

artículo científico publicado en 2003

Gas6 inflames cell interactions

artículo científico publicado en 2008

Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency.

artículo científico publicado en 2009

Growth-arrest-specific 6 (GAS6) protein in ARDS patients: determination of plasma levels and influence of PEEP setting

artículo científico publicado en 2013

Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene

article

Impact of heparin or non-heparin coated circuits on platelet function in pediatric cardiac surgery

artículo científico publicado en 2018

Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine.

artículo científico publicado en 2018

Inactivated antithrombins as fondaparinux antidotes: a promising alternative to haemostatic agents as assessed in vitro in a thrombin-generation assay.

artículo científico publicado en 2016

Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques

artículo científico publicado en 2011

Inefficacy of ultrasound-guided local injections of autologous conditioned plasma for recent epicondylitis: results of a double-blind placebo-controlled randomized clinical trial with one-year follow-up.

artículo científico publicado en 2015

Infections et inflammations

Inflammation in deep vein thrombosis: a therapeutic target?

artículo científico publicado en 2019

Influence of PROS1 gene mutations affecting protein S amino-acid 275 on plasma free protein S measurement

artículo científico publicado en 2007

International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up

artículo científico publicado en 2019

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

artículo científico publicado en 2018

Long-term follow-up in PMM2-CDG: are we ready to start treatment trials?

artículo científico publicado en 2018

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.

artículo científico publicado en 2009

Measuring beta-galactose exposure on platelets: Standardization and healthy reference values

artículo científico publicado en 2020

Molecular bases of type II protein S deficiency: the I203-D204 deletion in the EGF4 domain alters GLA domain function

artículo científico publicado en 2006

Molecular basis for protein S hereditary deficiency: Genetic defects observed in 118 patients with type I and type IIa deficiencies1

artículo científico publicado en 1996

Novel human pathological mutations. Gene symbol: PROS1. Disease: Protein S deficiency

article

Pathogenesis of meningococcal purpura fulminans.

artículo científico publicado en 2017

Pharmacokinetics of Enoxaparin After Renal Transplantation in Pediatric Patients

artículo científico publicado en 2018

Physiological Plasma Gas6 Levels Do Not Influence Platelet Aggregation

artículo científico publicado en 2006

Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects

artículo científico publicado en 2006

Platelet-mapping assay for monitoring antiplatelet therapy during mechanical circulatory support in children: A retrospective observational study

artículo científico publicado en 2017

Preanalytical influence of pneumatic tube delivery system on results of routine biochemistry and haematology analysis

artículo científico publicado en 2017

Protein C and protein S deficiencies.

artículo científico publicado en 1997

Protein S deficiency

artículo científico publicado en 1997

Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

artículo científico publicado el 1 de junio de 1997

Protein S deficiency: different biological phenotypes according to the assays used

artículo científico publicado en 1998

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence

scientific article published on 28 February 2019

Sepsis and coagulation

scientific article published on 01 October 2005

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

scientific article published on 01 December 2018

Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential.

artículo científico publicado en 2014

The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations

article

The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene is a frequent mutation associated with free protein S (type IIa) deficiency

article

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

artículo científico publicado en 2004

The protein S thrombin-sensitive region modulates phospholipid binding and the gamma-carboxyglutamic acid-rich (Gla) domain conformation in a non-specific manner

scientific article published on 01 March 2006

Three-dimensional model of the SHBG-like region of anticoagulant protein S: new structure-function insights

artículo científico publicado en 2001

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats.

artículo científico publicado en 2017

Trends in the development of oral anticoagulants

artículo científico publicado en 2015

Unbalance between plasma levels of Protein Z and protein Z-dependent inhibitor in patients with colorectal and pancreatic cancer: a pilot study.

artículo científico publicado en 2013

Vascular endothelial growth factor, as compared with placental growth factor, is increased in severe sepsis but not in organ failure

artículo científico publicado en 2012

Lista de obras de Delphine Borgel

A Comparative Study of the Protein C Pathway in Septic and Nonseptic Patients with Organ Failure

A capillary zone electrophoresis method to detect conformers and dimers of antithrombin in therapeutic preparations

A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity.

A fast capillary electrophoresis method to assess the binding affinity of recombinant antithrombin toward heparin directly from cell culture supernatants.

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation

A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients

Activated protein C, a protein at the crossroads between coagulation and inflammation

An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.

Antithrombin is not protective against renal ischaemia-reperfusion injury

Assessment of the interplay between blood and skin vascular abnormalities in adult purpura fulminans

Characterization of cleaved plasma protein S with a monoclonal antibody-based assay

Characterization of conformers and dimers of antithrombin by capillary electrophoresis-quadrupole-time-of-flight mass spectrometry

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.

Cleaved protein S (PS), total PS, free PS, and activated protein C cofactor activity as risk factors for venous thromboembolism

Clinical variability and probable founder effect in oculocutaneous albinism type 7

Clinical, laboratory and molecular findings and long-term follow-up data in 96 French patients with PMM2-CDG (phosphomannomutase 2-congenital disorder of glycosylation) and review of the literature.

Coagulation phenotypes in septic shock as evaluated by calibrated automated thrombography

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Connexin 37 limits thrombus propensity by downregulating platelet reactivity.

Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure*

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4

Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status.

Development of a recombinant antithrombin variant as a potent antidote to fondaparinux and other heparin derivatives

Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis

Elevated thrombin generation in patients with congenital disorder of glycosylation and combined coagulation factor deficiencies

Endothelial cell surface limits coagulation without modulating the antithrombin potency

Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations

First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484-->Pro, in the protein S active gene (PROS1)

First frameshift mutation in the active protein S gene associated with a quantitative hereditary deficiency

Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report

Functional properties of the sex-hormone-binding globulin (SHBG)-like domain of the anticoagulant protein S.

Gas6 inflames cell interactions

Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency.

Growth-arrest-specific 6 (GAS6) protein in ARDS patients: determination of plasma levels and influence of PEEP setting

Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene

Impact of heparin or non-heparin coated circuits on platelet function in pediatric cardiac surgery

Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine.

Inactivated antithrombins as fondaparinux antidotes: a promising alternative to haemostatic agents as assessed in vitro in a thrombin-generation assay.

Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques

Inefficacy of ultrasound-guided local injections of autologous conditioned plasma for recent epicondylitis: results of a double-blind placebo-controlled randomized clinical trial with one-year follow-up.

Infections et inflammations

Inflammation in deep vein thrombosis: a therapeutic target?

Influence of PROS1 gene mutations affecting protein S amino-acid 275 on plasma free protein S measurement

International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

Long-term follow-up in PMM2-CDG: are we ready to start treatment trials?

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.

Measuring beta-galactose exposure on platelets: Standardization and healthy reference values

Molecular bases of type II protein S deficiency: the I203-D204 deletion in the EGF4 domain alters GLA domain function

Molecular basis for protein S hereditary deficiency: Genetic defects observed in 118 patients with type I and type IIa deficiencies1

Novel human pathological mutations. Gene symbol: PROS1. Disease: Protein S deficiency

Pathogenesis of meningococcal purpura fulminans.

Pharmacokinetics of Enoxaparin After Renal Transplantation in Pediatric Patients

Physiological Plasma Gas6 Levels Do Not Influence Platelet Aggregation

Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects

Platelet-mapping assay for monitoring antiplatelet therapy during mechanical circulatory support in children: A retrospective observational study

Preanalytical influence of pneumatic tube delivery system on results of routine biochemistry and haematology analysis

Protein C and protein S deficiencies.

Protein S deficiency

Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

Protein S deficiency: different biological phenotypes according to the assays used

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence

Sepsis and coagulation

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential.

The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations

The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene is a frequent mutation associated with free protein S (type IIa) deficiency

The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.

The protein S thrombin-sensitive region modulates phospholipid binding and the gamma-carboxyglutamic acid-rich (Gla) domain conformation in a non-specific manner

Three-dimensional model of the SHBG-like region of anticoagulant protein S: new structure-function insights

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats.

Trends in the development of oral anticoagulants

Unbalance between plasma levels of Protein Z and protein Z-dependent inhibitor in patients with colorectal and pancreatic cancer: a pilot study.

Vascular endothelial growth factor, as compared with placental growth factor, is increased in severe sepsis but not in organ failure