Lista de obras - Giovanni Lentini - Dominio Público Uruguay

A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues

artículo científico publicado en 2018

A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma.

artículo científico publicado en 2017

A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells ⬇️

artículo científico publicado el 4 de julio de 2013

An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite

scientific article published on 01 June 2012

Antimicrobial and Antibiofilm Activities of Citrus Water-Extracts Obtained by Microwave-Assisted and Conventional Methods

artículo científico publicado en 2018

Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce

artículo científico publicado en 2023

COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

artículo científico publicado en 2020

Camel (Camelus spp.) Urine Bioactivity and Metabolome: A Systematic Review of Knowledge Gaps, Advances, and Directions for Future Research

scientific article published in 2022

Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity

artículo científico publicado en 2010

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

artículo científico publicado en 2013

Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]- (methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogen phosphate — methanol (1:1), [C26H30ClN2SO4][H2PO4] · CH4O

Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors

artículo científico publicado en 2010

Did Ebola survivors use plant medicines, and if so, which ones?

artículo científico publicado en 2015

Discovery of a new mexiletine-derived agonist of the hERG K+ channel.

artículo científico publicado en 2017

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

artículo científico publicado en 2017

Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity

scientific article published on 09 January 2015

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

artículo científico publicado en 2006

Facile entry to (-)-(R)- and (+)-(S)-mexiletine

artículo científico publicado en 2000

Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones

article published in 2010

Facile, alternative route to lubeluzole, its enantiomer, and the racemate

artículo científico publicado en 2006

First synthesis and full characterization of mexiletine N-carbonyloxy β-d-glucuronide

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

scientific article published on 22 July 2020

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

artículo científico publicado en 2000

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

artículo científico publicado en 2010

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

artículo científico publicado en 1999

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

artículo científico publicado en 2001

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine.

artículo científico publicado en 2015

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

artículo científico publicado en 2003

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

artículo científico publicado en 2015

Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective

artículo científico publicado en 2017

Microchip capillary electrophoresis-electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: an intriguing case

artículo científico publicado en 2013

Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization

artículo científico publicado en 2022

Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.

artículo científico publicado en 2018

Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.

artículo científico publicado en 2012

N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.

artículo científico publicado en 2012

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase

artículo científico publicado en 2010

New doxorubicin nanocarriers based on cyclodextrins

artículo científico publicado en 2017

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

artículo científico publicado en 2004

Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition.

artículo científico publicado en 2017

Old Drug Scaffold, New Activity: Thalidomide-Correlated Compounds Exert Different Effects on Breast Cancer Cell Growth and Progression

artículo científico publicado en 2017

One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

artículo científico publicado en 2003

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

artículo científico publicado en 2003

Optimization of Microwave-Assisted Extraction of Antioxidants from Bamboo Shoots of Phyllostachys pubescens

artículo científico publicado en 2020

Phytochemical, antioxidant and anti-α-glucosidase activity evaluations of Bergenia cordifolia

scientific article published on 22 November 2011

Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

artículo científico publicado en 2018

Recent trends and future prospects in computational GPCR drug discovery: from virtual screening to polypharmacology.

artículo científico publicado en 2013

Repurposing therapeutic agents and herbal medicines to defeat viral nemesis

scientific article published on 30 March 2020

Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers

artículo científico publicado en 2013

Shouldn't enantiomeric purity be included in the 'minimum information about a bioactive entity'? ⬇️

artículo científico publicado el 1 de septiembre de 2012

Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules.

artículo científico publicado en 2015

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

artículo científico publicado en 1995

Stereoselectivity in central analgesic action of tocainide and its analogs.

artículo científico publicado en 1993

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

artículo científico publicado en 2004

Stereospecific synthesis of m-Hydroxymexiletine enantiomers

scientific article published on 01 September 2012

Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

artículo científico publicado en 2007

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

artículo científico publicado en 2010

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

artículo científico publicado en 2012

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

artículo científico publicado en 2000

Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

artículo científico publicado en 2016

Targeting <i>Penicillium expansum</i> GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

artículo científico publicado en 2020

The Chemistry and Pharmacology of Citrus Limonoids

artículo científico publicado en 2016

The effects of tocainide and its chiral analogs on sodium channels of human muscle

artículo científico publicado en 1990

The therapeutic power of green

artículo científico publicado en 2019

The trivial names of citrus limonoids

artículo científico publicado en 2017

Lista de obras de Giovanni Lentini

A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues

A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma.

A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells ⬇️

An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite

Antimicrobial and Antibiofilm Activities of Citrus Water-Extracts Obtained by Microwave-Assisted and Conventional Methods

Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce

COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

Camel (Camelus spp.) Urine Bioactivity and Metabolome: A Systematic Review of Knowledge Gaps, Advances, and Directions for Future Research

Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]- (methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogen phosphate — methanol (1:1), [C26H30ClN2SO4][H2PO4] · CH4O

Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors

Did Ebola survivors use plant medicines, and if so, which ones?

Discovery of a new mexiletine-derived agonist of the hERG K+ channel.

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

Facile entry to (-)-(R)- and (+)-(S)-mexiletine

Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones

Facile, alternative route to lubeluzole, its enantiomer, and the racemate

First synthesis and full characterization of mexiletine N-carbonyloxy β-d-glucuronide

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine.

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective

Microchip capillary electrophoresis-electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: an intriguing case

Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization

Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.

Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.

N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase

New doxorubicin nanocarriers based on cyclodextrins

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition.

Old Drug Scaffold, New Activity: Thalidomide-Correlated Compounds Exert Different Effects on Breast Cancer Cell Growth and Progression

One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

Optimization of Microwave-Assisted Extraction of Antioxidants from Bamboo Shoots of Phyllostachys pubescens

Phytochemical, antioxidant and anti-α-glucosidase activity evaluations of Bergenia cordifolia

Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

Recent trends and future prospects in computational GPCR drug discovery: from virtual screening to polypharmacology.

Repurposing therapeutic agents and herbal medicines to defeat viral nemesis

Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers

Shouldn't enantiomeric purity be included in the 'minimum information about a bioactive entity'? ⬇️

Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules.

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

Stereoselectivity in central analgesic action of tocainide and its analogs.

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

Stereospecific synthesis of m-Hydroxymexiletine enantiomers

Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

Targeting <i>Penicillium expansum</i> GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

The Chemistry and Pharmacology of Citrus Limonoids

The effects of tocainide and its chiral analogs on sodium channels of human muscle

The therapeutic power of green

The trivial names of citrus limonoids