Lista de obras - Luis C. López - Dominio Público Uruguay

A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease

artículo científico publicado en 2009

A review of the melatonin functions in zebrafish physiology

artículo científico publicado en 2014

ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency

artículo científico publicado en 2008

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis.

artículo científico publicado en 2017

Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: Effects of melatonin treatment

scientific article published on 17 October 2006

Analysis of the daily changes of melatonin receptors in the rat liver

artículo científico publicado en 2012

Antioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly.

artículo científico publicado en 2017

Argan oil-contained antioxidants for human mitochondria.

artículo científico

Assessment of thymidine phosphorylase function: measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity

artículo científico publicado en 2012

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

artículo científico publicado en 2007

Bypassing human CoQ10 deficiency

artículo científico publicado en 2017

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

artículo científico publicado en 2007

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.

artículo científico publicado en 2007

Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice

artículo científico publicado en 2007

Clinical and genetic analysis of lipid storage myopathies

artículo científico publicado en 2009

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

artículo científico publicado en 2016

CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway

scientific article published on 06 September 2018

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

artículo científico publicado en 2017

Composition and Antioxidant Properties of Spanish Extra Virgin Olive Oil Regarding Cultivar, Harvest Year and Crop Stage

artículo científico publicado en 2019

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function.

artículo científico publicado en 2013

Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.

artículo científico publicado en 2014

Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

artículo científico publicado en 2017

Determination of Coenzyme Q10, Coenzyme Q9, and Melatonin Contents in Virgin Argan Oils: Comparison with Other Edible Vegetable Oils

scientific article published on 31 October 2011

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

artículo científico publicado en 2015

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency

scientific journal article

ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency

artículo científico publicado en 2009

Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

artículo científico publicado en 2013

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

artículo científico publicado en 2011

Extrapineal melatonin: sources, regulation, and potential functions.

artículo científico

Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice.

artículo científico publicado en 2016

Heterogeneity of coenzyme Q10 deficiency: patient study and literature review

artículo científico publicado en 2012

Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats

scientific article published on 24 January 2019

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.

artículo científico publicado en 2005

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

artículo científico publicado en 2014

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

artículo científico publicado en 2016

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.

artículo científico publicado en 2008

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

artículo científico publicado en 2017

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

artículo científico publicado en 2006

Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin

scientific article published on 01 October 2019

Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway.

artículo científico publicado en 2015

Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations

artículo científico publicado en 2006

Long-term melatonin administration protects brain mitochondria from aging.

artículo científico publicado en 2009

Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum

artículo científico publicado en 2004

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

artículo científico publicado en 2019

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

artículo científico publicado en 2017

Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

artículo científico publicado en 2009

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

artículo científico publicado en 2014

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

artículo científico publicado en 2006

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

artículo científico publicado en 2017

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

artículo científico publicado en 2011

Melatonin protects lung mitochondria from aging ⬇️

artículo científico publicado el 26 de mayo de 2011

Melatonin protects rats from radiotherapy-induced small intestine toxicity

artículo científico publicado en 2017

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

artículo científico publicado en 2016

Melatonin restores the mitochondrial production of ATP in septic mice

artículo científico publicado en 2006

Melatonin role in the mitochondrial function.

artículo científico publicado en 2007

Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy

artículo científico publicado en 2011

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

artículo científico publicado en 2010

Melatonin, clock genes and mitochondria in sepsis.

artículo científico

Mitochondrial DNA and inflammatory diseases.

artículo científico publicado en 2011

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

artículo científico publicado en 2017

Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.

artículo científico publicado en 2010

Pathomechanisms in coenzyme q10-deficient human fibroblasts

artículo científico publicado en 2014

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

artículo científico publicado en 2015

Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats

artículo científico publicado en 2014

Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

artículo científico publicado en 2011

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease

artículo científico publicado en 2019

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

artículo científico publicado en 2018

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

artículo científico publicado en 2015

Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide

artículo científico publicado en 2011

The Protective Effect of Melatonin Against Age-Associated Sarcopenia-Dependent Tubular Aggregates Formation, Lactate Depletion and Mitochondrial Changes.

artículo científico publicado en 2018

The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency

The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency

artículo científico publicado en 2017

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

artículo científico publicado en 2013

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

artículo científico publicado en 2015

Thymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

artículo científico publicado en 2007

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.

artículo científico publicado en 2008

Treatment of CoQ10 Deficient Fibroblasts with Ubiquinone, CoQ Analogs, and Vitamin C: Time- and Compound-Dependent Effects ⬇️

artículo científico publicado el 30 de julio de 2010

Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency

artículo científico publicado en 2014

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in mice

artículo científico publicado en 2019

Lista de obras de Luis C. López

A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease

A review of the melatonin functions in zebrafish physiology

ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis.

Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: Effects of melatonin treatment

Analysis of the daily changes of melatonin receptors in the rat liver

Antioxidant effect of exercise: Exploring the role of the mitochondrial complex I superassembly.

Argan oil-contained antioxidants for human mitochondria.

Assessment of thymidine phosphorylase function: measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

Bypassing human CoQ10 deficiency

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.

Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice

Clinical and genetic analysis of lipid storage myopathies

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

Composition and Antioxidant Properties of Spanish Extra Virgin Olive Oil Regarding Cultivar, Harvest Year and Crop Stage

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function.

Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.

Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Determination of Coenzyme Q10, Coenzyme Q9, and Melatonin Contents in Virgin Argan Oils: Comparison with Other Edible Vegetable Oils

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency

ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency

Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

Extrapineal melatonin: sources, regulation, and potential functions.

Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice.

Heterogeneity of coenzyme Q10 deficiency: patient study and literature review

Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin

Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway.

Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations

Long-term melatonin administration protects brain mitochondria from aging.

Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

Melatonin protects lung mitochondria from aging ⬇️

Melatonin protects rats from radiotherapy-induced small intestine toxicity

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

Melatonin restores the mitochondrial production of ATP in septic mice

Melatonin role in the mitochondrial function.

Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

Melatonin, clock genes and mitochondria in sepsis.

Mitochondrial DNA and inflammatory diseases.

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.

Pathomechanisms in coenzyme q10-deficient human fibroblasts

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats

Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide

The Protective Effect of Melatonin Against Age-Associated Sarcopenia-Dependent Tubular Aggregates Formation, Lactate Depletion and Mitochondrial Changes.

The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency

The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

Thymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.

Treatment of CoQ10 Deficient Fibroblasts with Ubiquinone, CoQ Analogs, and Vitamin C: Time- and Compound-Dependent Effects ⬇️

Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in mice