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Lista de obras de Lude Franke

52 Genetic Loci Influencing Myocardial Mass

artículo científico publicado en 2016

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

artículo científico publicado en 2016

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

scientific article published on 26 September 2019

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

A first update on mapping the human genetic architecture of COVID-19

artículo científico publicado en 2022

A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis

artículo científico publicado en 2013

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

artículo científico publicado en 2007

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

artículo científico publicado en 2011

A genome-wide association study of circulating galectin-3

artículo científico publicado en 2012

A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.

artículo científico publicado en 2014

A linear mixed model approach to study multivariate gene-environment interactions

article

A linear mixed-model approach to study multivariate gene–environment interactions

article

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

scientific journal article

A novel common variant in DCST2 is associated with length in early life and height in adulthood

artículo científico publicado en 2014

A strategy to search for common obesity and type 2 diabetes genes

artículo científico publicado en 2006

ATR inhibition preferentially targets homologous recombination-deficient tumor cells.

artículo científico publicado en 2014

An epigenome-wide association study meta-analysis of educational attainment.

artículo científico publicado en 2017

An integrative systems genetics approach reveals potential causal genes and pathways related to obesity

artículo científico publicado en 2015

Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease

artículo científico publicado en 2010

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

artículo científico publicado en 2016

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

artículo científico publicado en 2015

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

artículo científico publicado en 2022

Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

artículo científico publicado en 2018

Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

scholarly article published in Nature Genetics

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles

artículo científico publicado en 2013

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

artículo científico publicado en 2014

Biological interpretation of genome-wide association studies using predicted gene functions

artículo científico publicado en 2015

Blood lipids influence DNA methylation in circulating cells

artículo científico publicado en 2016

Blood pressure loci identified with a gene-centric array

artículo científico publicado en 2011

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

artículo científico publicado en 2017

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

artículo científico publicado en 2019

Celiac disease: moving from genetic associations to causal variants

artículo científico publicado en 2011

Cell Specific eQTL Analysis without Sorting Cells

artículo científico publicado en 2015

Cell specific eQTL analysis without sorting cells

Ciliary genes are down-regulated in bronchial tissue of primary ciliary dyskinesia patients

artículo científico publicado en 2014

Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study

artículo científico publicado en 2010

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

artículo científico publicado en 2009

Combination of text-mining algorithms increases the performance

artículo científico

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

artículo científico

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

artículo científico

Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis

artículo científico publicado en 2014

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

artículo científico publicado en 2014

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

artículo científico publicado en 2010

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.

artículo científico publicado en 2014

Complex nature of SNP genotype effects on gene expression in primary human leucocytes

artículo científico publicado en 2009

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

artículo científico publicado en 2016

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer

artículo científico publicado en 2014

Copy number variants on the X chromosome in women with primary ovarian insufficiency

artículo científico publicado en 2011

Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screen

artículo científico

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Correlation of genetic risk and messenger RNA expression in a Th17/IL23 pathway analysis in inflammatory bowel disease

artículo científico publicado en 2014

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

artículo científico publicado en 2016

DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts

artículo científico publicado en 2013

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

artículo científico publicado en 2011

Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays

artículo científico publicado en 2008

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

artículo científico publicado en 2016

Discovery and fine mapping of serum protein loci through transethnic meta-analysis

artículo científico publicado en 2012

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

artículo científico publicado en 2016

Disease variants alter transcription factor levels and methylation of their binding sites

artículo científico publicado en 2016

Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.

artículo científico publicado en 2014

Distinction in EEG slow oscillations between chronic mild traumatic brain injury and PTSD.

artículo científico publicado en 2016

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

artículo científico publicado en 2017

Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study

artículo científico publicado en 2016

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

artículo científico publicado en 2016

Erratum: Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function and bipolar disorder susceptibility

scholarly article published in Molecular Psychiatry

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Erratum: Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi

article

Erratum: Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

artículo científico publicado en 2016

Evaluation of European coeliac disease risk variants in a north Indian population

artículo científico publicado en 2015

Evidence for mitochondrial genetic control of autosomal gene expression

artículo científico publicado en 2016

Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection

artículo científico publicado en 2010

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

artículo científico publicado en 2014

Extraintestinal manifestations and complications in inflammatory bowel disease: from shared genetics to shared biological pathways

artículo científico

Feasibility of predicting allele specific expression from DNA sequencing using machine learning

artículo científico publicado en 2021

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant

artículo científico publicado en 2013

From genome to function by studying eQTLs

artículo científico publicado en 2014

Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis

artículo científico publicado en 2015

Further pharmacological characterization of eltoprazine: focus on its anxiolytic, anorexic, and adverse‑effect potential.

artículo científico publicado en 2017

GAVIN - Gene-Aware Variant INterpretation for medical sequencing

article

GAVIN: Gene-Aware Variant INterpretation for medical sequencing

artículo científico publicado en 2017

GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

artículo científico publicado en 2017

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

artículo científico publicado en 2013

Gene co-expression analysis for functional classification and gene-disease predictions

artículo científico publicado en 2017

Gene expression analysis identifies global gene dosage sensitivity in cancer.

artículo científico publicado en 2015

Gene-network analysis identifies susceptibility genes related to glycobiology in autism

artículo científico publicado en 2009

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

artículo científico publicado en 2008

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

artículo científico publicado en 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

artículo científico publicado en 2014

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

artículo científico publicado en 2016

Genetic evidence of assortative mating in humans

article

Genetic insights into biological mechanisms governing human ovarian ageing

artículo científico publicado en 2021

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

artículo científico publicado en 2017

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

artículo científico publicado en 2016

Genetic variants in RBFOX3 are associated with sleep latency

artículo científico publicado en 2016

Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.

artículo científico publicado en 2013

Genetic variants of inducible costimulator are associated with allergic asthma susceptibility.

artículo científico publicado en 2014

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

artículo científico publicado en 2007

Genetic, parental and lifestyle factors influence telomere length

artículo científico publicado en 2022

Genetics of rheumatoid arthritis contributes to biology and drug discovery

artículo científico publicado en 2013

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

article

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

artículo científico publicado en 2016

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

artículo científico publicado en 2010

Genome-wide analysis shows no genomic predictors of ovarian response to stimulation by exogenous FSH for IVF.

artículo científico publicado en 2010

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

artículo científico publicado en 2016

Genome-wide association analyses identify variants in developmental genes associated with hypospadias

artículo científico publicado en 2014

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention ⬇️

artículo científico publicado en 2022

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

artículo científico publicado en 2015

Genome-wide association study identifies 74 loci associated with educational attainment

artículo científico publicado en 2016

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

artículo científico publicado en 2012

Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene

artículo científico publicado en 2009

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

artículo científico publicado en 2014

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

article

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

artículo científico publicado en 2016

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

artículo científico publicado en 2020

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

artículo científico publicado en 2017

HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort

article

Hemani et al. reply

artículo científico publicado en 2014

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

artículo científico publicado en 2012

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

artículo científico publicado en 2013

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

artículo científico publicado en 2013

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study

scientific journal article

Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model

artículo científico publicado en 2014

Identification of context-dependent expression quantitative trait loci in whole blood

artículo científico publicado en 2016

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

artículo científico publicado en 2013

Identification of the oxidative stress-related gene MSRA as a rheumatoid arthritis susceptibility locus by genome-wide pathway analysis

artículo científico publicado en 2010

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

artículo científico publicado en 2014

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.

artículo científico publicado en 2014

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants

artículo científico publicado en 2013

Improving the diagnostic yield of exome- sequencing by predicting gene-phenotype associations using large-scale gene expression analysis

artículo científico publicado en 2019

Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

artículo científico publicado en 2021

Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals

artículo científico publicado en 2016

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi

artículo científico publicado en 2016

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

artículo científico publicado en 2022

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

artículo científico publicado en 2016

Interspecific sensitivity of bees towards dimethoate and implications for environmental risk assessment

artículo científico publicado en 2016

Laboratory impulsivity and depression in blast-exposed military personnel with post-concussion syndrome

artículo científico publicado en 2016

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

artículo científico publicado en 2017

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

artículo científico publicado en 2015

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

scientific article published on 03 April 2019

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.

artículo científico publicado en 2012

Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians

artículo científico publicado en 2014

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

artículo científico publicado en 2016

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

scientific journal article

MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects

artículo científico publicado en 2011

Multiple common variants for celiac disease influencing immune gene expression

artículo científico publicado en 2010

Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect

artículo científico publicado en 2005

Neutrophil Recruitment and Barrier Impairment in Celiac Disease: A Genomic Study

article published in 2007

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

Newly identified genetic risk variants for celiac disease related to the immune response

artículo científico publicado en 2008

No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study

artículo científico publicado en 2008

No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population

artículo científico publicado en 2005

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

artículo científico publicado en 2014

Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

artículo científico publicado en 2007

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

artículo científico publicado en 2013

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

artículo científico publicado en 2014

Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain.

artículo científico publicado en 2015

Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies

artículo científico publicado en 2017

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

artículo científico publicado en 2018

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

artículo científico publicado en 2014

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells

artículo científico publicado en 2017

Pollen-ovule relation in Adesmia tristis and reflections on the seed-ovule ratio by interaction with pollinators in two vertical strata

artículo científico publicado en 2014

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

artículo científico publicado en 2016

Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease

artículo científico publicado en 2020

Prevalence of mental health conditions after military blast exposure, their co-occurrence, and their relation to mild traumatic brain injury.

artículo científico publicado en 2015

Proteomic studies related to genetic determinants of variability in protein concentrations

artículo científico

Proton pump inhibitors affect the gut microbiome

artículo científico publicado en 2015

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

retracted scholarly article

Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes

artículo científico

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

artículo científico publicado en 2016

Reply to 'Misestimation of heritability and prediction accuracy of male-pattern baldness'.

artículo científico publicado en 2018

SMIM1 underlies the Vel blood group and influences red blood cell traits

artículo científico publicado en 2013

Seventy-five genetic loci influencing the human red blood cell

artículo científico publicado en 2012

Shared genetic variants suggest common pathways in allergy and autoimmune diseases

artículo científico publicado en 2017

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs.

artículo científico publicado en 2018

Skewed X-inactivation is common in the general female population

artículo científico publicado en 2018

Symptom Trajectories After Military Blast Exposure and the Influence of Mild Traumatic Brain Injury

artículo científico publicado en 2016

Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels

artículo científico publicado en 2014

Systematic genotype-phenotype analysis of autism susceptibility loci implicates additional symptoms to co-occur with autism

artículo científico publicado en 2009

Systematic identification of trans eQTLs as putative drivers of known disease associations

artículo científico publicado en 2013

TEAM: a tool for the integration of expression, and linkage and association maps

artículo científico publicado en 2004

The Chronic Effects of Neurotrauma Consortium (CENC) multi-centre observational study: Description of study and characteristics of early participants

artículo científico publicado en 2016

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The effect of host genetics on the gut microbiome

artículo científico

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

artículo científico publicado en 2016

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

artículo científico publicado en 2016

The lebercilin-like protein is embedded in a ciliary protein network and is preferentially expressed in motile cilia.

artículo científico publicado en 2012

The single-cell eQTLGen consortium

artículo científico publicado en 2020

The transcriptional landscape of age in human peripheral blood

artículo científico publicado en 2015

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

artículo científico publicado en 2015

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

artículo científico publicado en 2011

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram

artículo científico publicado en 2016

Understanding human immune function using the resources from the Human Functional Genomics Project

artículo científico publicado en 2016

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression

artículo científico publicado en 2012

Using genome-wide pathway analysis to unravel the etiology of complex diseases.

artículo científico publicado en 2009

Wnt signaling and Dupuytren's disease

artículo científico publicado en 2011

eQTL analysis in humans

artículo científico publicado en 2009

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