Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Autoría

autor: Philip Van Damme, Tom R. Gaunt, Naomi R. Wray, Lude Franke, Russell McLaughlin, Catherine M Olsen, David C. Whiteman, Marta Gromicho, Ammar Al-Chalabi, Wouter van Rheenen, Patrick Deelen, Nicholas W. Wood, Nicola Ticozzi, Eilis Hannon, Vincenzo Silani, Gerome Breen, Simon Topp, Kelly L Williams, Dominic B Rowe, Thomas Meyer, Maarten Kooyman, Blaž Koritnik, Julia Kraft, Vivianna M Van Deerlin, Michael Eberle, Ross P Byrne, Mark K. Bakker, Jeroen Pasterkamp, Roger Pamphlett, Boris Rogelj, Jay P Ross, Marcella Rietschel, Franke A, Ricard Rojas-Garcia, Jan H Veldink, Michael A van Es, Ewout J N Groen, Peter M Andersen, Ahmad Al Khleifat, Jonathan D Glass, Ellen Tsai, Guy A. Rouleau, George Davey Smith, Perminder Sachdev, Andrea Calvo, André Uitterlinden, Harm-Jan Westra, Philippe Amouyel, Jonathan Mill