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Lista de obras de Philippe Froguel

8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016

article

A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes

artículo científico publicado en 2004

A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature

article

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

article

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

artículo científico publicado en 2018

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

artículo científico publicado en 2017

A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease

article

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

artículo científico publicado en 2006

A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity

article

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A central role for GRB10 in regulation of islet function in man.

artículo científico publicado en 2014

A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report

artículo científico publicado en 2020

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

artículo científico publicado en 2009

A frameshift mutation in human MC4R is associated with a dominant form of obesity ⬇️

artículo científico publicado el 1 de octubre de 1998

A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q

artículo científico publicado en 1995

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

article

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

artículo científico publicado en 2012

A genome-wide association meta-analysis identifies new childhood obesity loci

artículo científico publicado en 2012

A genome-wide association search for type 2 diabetes genes in African Americans

artículo científico publicado en 2012

A genome-wide association study identifies novel risk loci for type 2 diabetes

artículo científico publicado en 2007

A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels

artículo científico publicado en 2012

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

artículo científico publicado en 2010

A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2.

artículo científico publicado en 2004

A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27 ⬇️

artículo científico publicado el 15 de noviembre de 2001

A girl with incomplete Prader-Willi syndrome and negative MS-PCR, found to have mosaic maternal UPD-15 at SNP array.

artículo científico publicado en 2015

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.

artículo científico publicado en 2011

A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes

artículo científico publicado en 2003

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus

artículo científico publicado en 1998

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction ⬇️

artículo científico publicado el 26 de marzo de 1998

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

artículo científico publicado en 2010

A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity

artículo científico publicado en 2014

A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome.

artículo científico publicado en 2017

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

artículo científico publicado en 2008

A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population

artículo científico publicado en 2004

A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family

artículo científico publicado en 2002

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults

artículo científico publicado en 2008

A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q.

artículo científico publicado en 1999

A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents

artículo científico publicado en 2007

A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians

scientific article published on 01 August 2005

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

scientific article published on 01 October 2019

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

artículo científico publicado en 2008

A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children

artículo científico publicado en 2002

ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult Obesity

artículo científico publicado en 2006

ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity

scientific article published on 01 December 2005

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease

artículo científico publicado en 2009

Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry

artículo científico publicado en 2011

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

artículo científico publicado en 2006

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits

artículo científico publicado en 2007

Adipocytokins, obesity and development of type 2 diabetes

artículo científico publicado en 2005

Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study

artículo científico publicado en 2004

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

artículo científico publicado en 2002

Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies

artículo científico publicado en 2006

Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines

artículo científico publicado en 2013

Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men.

artículo científico publicado en 2012

Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study

artículo científico publicado en 2012

Allelic variation in exon 18 of the sulfonylurea receptor 1 (SUR1) gene, insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects.

artículo científico publicado en 2002

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

artículo científico publicado en 1996

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level

artículo científico publicado en 2014

An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort

artículo científico publicado en 2000

Analysis of KLF transcription factor family gene variants in type 2 diabetes

artículo científico publicado en 2007

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

artículo científico publicado en 2006

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study

artículo científico publicado en 2008

Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

artículo científico publicado en 2005

Analysis of the SIM1 contribution to polygenic obesity in the French population

artículo científico publicado en 2010

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

artículo científico publicado en 2013

Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

artículo científico publicado en 2013

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases

article

Assessment of insulin sensitivity in glucokinase-deficient subjects.

artículo científico publicado en 1996

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

artículo científico publicado en 2010

Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children

artículo científico publicado en 2007

Association between high von Willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes

article

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

artículo científico publicado en 2013

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of Melanin-Concentrating Hormone Receptor 1 5' Polymorphism With Early-Onset Extreme Obesity

artículo científico publicado en 2005

Association of gene variants with susceptibility to type 2 diabetes among Omanis

artículo científico publicado en 2015

Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children ⬇️

artículo científico publicado en 2011

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity

scientific article published on 14 July 2011

Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population

artículo científico publicado en 2008

Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses

article

Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity

artículo científico publicado en 2009

Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths.

artículo científico publicado en 2016

Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians

artículo científico publicado en 2006

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.

artículo científico publicado en 2014

Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice

artículo científico publicado en 2014

Bio-Repository of DNA in stroke (BRAINS): a study protocol

artículo científico publicado en 2011

Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes

artículo científico publicado en 2009

C-Jun amino terminal kinase 3 (JNK3) contrôle la masse fonctionnelle de la cellule bêta en réponse à l’obésité

artículo científico publicado en 2017

CA repeat polymorphism in the glucose transporter GLUT 2 gene ⬇️

artículo científico publicado el 11 de julio de 1991

CDKN2B expression and subcutaneous adipose tissue expandability: possible influence of the 9p21 atherosclerosis locus

artículo científico publicado en 2014

CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques

artículo científico publicado en 2016

Cdkn2a deficiency promotes adipose tissue browning

artículo científico publicado en 2017

Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects

artículo científico publicado en 2013

Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis

artículo científico publicado en 2017

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

artículo científico publicado en 2014

Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM

artículo científico publicado en 1995

Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM

article

Characterization of the human SLC30A8 promoter and intronic enhancer

artículo científico

Childhood obesity is associated with shorter leukocyte telomere length

artículo científico publicado en 2011

Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study

artículo científico publicado en 2020

Clinical and metabolic features of adult-onset diabetes caused by ABCC8 mutations

artículo científico publicado en 2011

Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).

artículo científico publicado en 2009

Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation

artículo científico publicado en 1996

Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes

scientific journal article

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

artículo científico publicado en 2003

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

artículo científico publicado en 1995

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

artículo científico publicado en 1995

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

artículo científico publicado el 12 de marzo de 1992

CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability.

artículo científico publicado en 2018

Coexistence in the Same Family of Both Focal and Diffuse Forms of Hyperinsulinism

article

Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease

artículo científico publicado en 2017

Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

artículo científico publicado en 2013

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations

artículo científico publicado en 2009

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

artículo científico publicado en 2007

Comment on Beltrand et al. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033-2041.

artículo científico publicado en 2016

Comment on: Valette et al. Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. PLOS ONE 2012; 7(11):E48221.

artículo científico publicado en 2014

Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians.

artículo científico publicado en 2005

Common genetic variants and risk of brain injury after preterm birth.

artículo científico publicado en 2014

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

artículo científico publicado en 2008

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians

artículo científico publicado en 2009

Common nonsynonymous variants in PCSK1 confer risk of obesity

article

Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians

artículo científico publicado en 2005

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

artículo científico publicado en 2010

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

artículo científico publicado en 2013

Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population

artículo científico publicado en 2011

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

artículo científico publicado en 2013

Common variants near MC4R are associated with fat mass, weight and risk of obesity

artículo científico publicado en 2008

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

artículo científico publicado en 2012

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians

artículo científico publicado en 2009

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects

artículo científico publicado en 2007

Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population

artículo científico publicado en 2010

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

artículo científico publicado en 2012

Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications

artículo científico publicado en 2019

Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels

artículo científico publicado en 2015

Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study

artículo científico publicado en 2009

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

scientific article published on 27 March 2017

Correction: Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets.

artículo científico publicado en 2006

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Corrigendum to “High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families” [Mol. Genet. Metab. 106/1 (2012) 121–126]

article

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

artículo científico publicado en 2016

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

artículo científico publicado en 2017

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice ⬇️

artículo científico publicado el 15 de mayo de 1998

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

artículo científico publicado en 1999

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

artículo científico publicado en 2011

Detection of human adaptation during the past 2000 years

artículo científico publicado en 2016

Determination of peritoneal glucose kinetics in rats: implications for the peritoneal implantation of closed-loop insulin delivery systems

artículo científico publicado en 1989

Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q.

artículo científico publicado en 1996

Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

artículo científico publicado en 2007

Diabète néonatal (monogénique de la très petite enfance). État des travaux du Réseau Français d’étude du diabète néonatal

artículo científico publicado en 2012

Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study.

artículo científico publicado en 2011

Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue.

artículo científico publicado en 2011

Direct estimates of natural selection in Iberia indicate calcium absorption was not the only driver of lactase persistence in Europe

artículo científico publicado en 2014

Directional dominance on stature and cognition in diverse human populations

artículo científico publicado en 2015

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

scientific article published on 15 June 2019

Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?

artículo científico publicado en 2017

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

artículo científico publicado en 2011

Disruption of adiponectin causes insulin resistance and neointimal formation

scientific journal article

Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation.

artículo científico publicado en 2003

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women

artículo científico publicado en 2006

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS

artículo científico publicado en 2018

Does Type 2 diabetes increase the risk of developing cancer?

artículo científico publicado en 2013

Does the −11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?

article

Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine

artículo científico publicado en 2003

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

artículo científico publicado en 2012

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

scientific journal article

EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families

artículo científico publicado en 2006

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study

article by D. Meyre et al published 18 August 2007 in Diabetologia

ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes

artículo científico publicado en 2006

Early detrimental metabolic outcomes of rs17300539-A allele of ADIPOQ gene despite higher adiponectinemia

artículo científico publicado en 2009

Early metabolic markers identify potential targets for the prevention of type 2 diabetes

artículo científico

Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study

artículo científico publicado en 2016

Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population

artículo científico publicado en 2008

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death

scientific article published on 21 November 2019

Effect of common polymorphisms in the HNF4? promoter on susceptibility to type 2 diabetes in the French Caucasian population

article

Effects of TCF7L2 polymorphisms on obesity in European populations

artículo científico publicado en 2008

Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study

artículo científico publicado en 2011

Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes

scientific article published on 22 September 2020

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

artículo científico publicado en 2008

Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

artículo científico publicado en 2016

Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway

artículo científico publicado en 2011

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

artículo científico publicado en 2021

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

artículo científico publicado en 2015

Epigenome-wide association study of adiposity and future risk of obesity-related diseases

article by Gianluca Campanella et al published 1 May 2018 in International Journal of Obesity

Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

artículo científico publicado en 2006

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scholarly article published in Nature Genetics

Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

scholarly article by Johan Rung et al published October 2009 in Nature Genetics

Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population.

artículo científico publicado en 2017

Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2018

Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

scholarly article published in Obesity

Erratum: corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

artículo científico publicado en 2004

Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts

artículo científico publicado en 2012

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose

artículo científico publicado en 2008

European genetic variants associated with type 2 diabetes in North African Arabs

artículo científico publicado en 2012

Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population

article

Evaluating the association of common APOA2 variants with type 2 diabetes

artículo científico publicado en 2009

Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids

artículo científico publicado en 2007

Evaluating the association of common PBX1 variants with type 2 diabetes

artículo científico publicado en 2008

Evaluation of A2BP1 as an obesity gene ⬇️

artículo científico publicado en 2010

Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians

artículo científico publicado en 2008

Evidence for leptin receptor isoforms heteromerization at the cell surface

artículo científico publicado en 2010

Evidence for tuning adipocytes ICER levels for obesity care

artículo científico publicado en 2012

Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.

artículo científico publicado en 1997

Examining the Candidacy of Ghrelin as a Gene Responsible for Variation in Adult Stature in a United Kingdom Population with Type 2 Diabetes

article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

artículo científico publicado en 2012

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

artículo científico publicado en 2017

Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors

artículo científico publicado en 2011

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

artículo científico publicado en 2007

Familial early-onset diabetes is not a typical MODY in several Tunisian patients

artículo científico publicado el 1 de diciembre de 2012

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus

artículo científico publicado en 1993

Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations

artículo científico publicado en 2011

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

artículo científico publicado en 2018

Fine-scale human genetic structure in Western France

artículo científico publicado en 2014

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

artículo científico publicado en 2018

Fostering improved human islet research: a European perspective

scientific article published on 13 June 2019

From obesity genetics to the future of personalized obesity therapy

artículo científico publicado en 2013

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study

artículo científico publicado en 2009

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans

artículo científico publicado en 2009

GAD2 on chromosome 10p12 is a candidate gene for human obesity

artículo científico publicado en 2003

GAD2: A polygenic contribution to genetic susceptibility for common obesity?

GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes

artículo científico publicado en 2012

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

artículo científico publicado en 2013

Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity

artículo científico publicado el 1 de noviembre de 1997

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

artículo científico publicado en 2014

General regression model: A "model-free" association test for quantitative traits allowing to test for the underlying genetic model

scientific article published on 13 December 2019

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation.

artículo científico publicado en 2017

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation.

artículo científico publicado en 2018

Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence (≥49%) in an Inbred Population of Pakistan

artículo científico publicado en 2020

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

scientific article published on 16 December 2019

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

artículo científico publicado en 2009

Genetic Study of the Melanin-Concentrating Hormone Receptor 2 in Childhood and Adulthood Severe Obesity

article by Maya Ghoussaini et al published November 2007 in The Journal of Clinical Endocrinology and Metabolism

Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population

scientific article published on 01 March 2006

Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.

artículo científico publicado en 2008

Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families

artículo científico publicado en 2000

Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

artículo científico publicado en 2010

Genetic approaches to the molecular understanding of type 2 diabetes

artículo científico publicado en 2002

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

artículo científico publicado en 2015

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

artículo científico publicado en 2016

Genetic associations with human longevity at the APOE and ACE loci

artículo científico publicado en 1994

Genetic basis of maturity-onset diabetes of the young

artículo científico publicado en 2006

Genetic determinants of leucocyte telomere length in children: a neglected and challenging field

artículo científico publicado en 2015

Genetic determinants of non-insulin-dependent diabetes mellitus: strategies and recent results

artículo científico publicado en 1997

Genetic determinants of type 2 diabetes

artículo científico publicado en 2001

Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies.

artículo científico publicado en 1993

Genetic evidence of assortative mating in humans

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

artículo científico publicado en 2015

Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome

artículo científico publicado en 2003

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

artículo científico publicado en 1994

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets

artículo científico publicado en 2006

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity ⬇️

artículo científico publicado el 1 de junio de 1997

Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery

artículo científico publicado el 1 de junio de 1998

Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families ⬇️

artículo científico publicado el 1 de octubre de 1997

Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians

artículo científico publicado en 1997

Genetic study of the CD36 gene in a French diabetic population

artículo científico publicado en 2004

Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.

artículo científico publicado en 1997

Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits

artículo científico publicado en 2009

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

artículo científico publicado en 2009

Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population.

artículo científico publicado en 2015

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity

artículo científico publicado en 1995

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

artículo científico publicado en 2002

Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients ⬇️

artículo científico publicado el 1 de enero de 2002

Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs

artículo científico

Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs

article

Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes

artículo científico publicado en 2018

Genetics of Pathways Regulating Body Weight in the Development of Obesity in Humans ⬇️

artículo científico publicado el 1 de diciembre de 2001

Genetics of human obesity

artículo científico publicado en 2001

Genetics of obesity

artículo científico publicado en 2002

Genetics of obesity and the prediction of risk for health

artículo científico publicado en 2006

Genetics of obesity: towards the understanding of a complex syndrome.

artículo científico publicado en 2000

Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians

artículo científico publicado en 2004

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

scientific article published on 01 July 2019

Genome-wide Linkage Analysis for Severe Obesity in French Caucasians Finds Significant Susceptibility Locus on Chromosome 19q

article

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

artículo científico publicado en 2016

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

artículo científico publicado en 2013

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

artículo científico publicado en 2015

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

artículo científico publicado en 2011

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

artículo científico publicado en 2009

Genome-wide association study identifies five loci associated with lung function

artículo científico publicado en 2010

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

artículo científico publicado en 2011

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

artículo científico publicado en 2011

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

artículo científico publicado en 2017

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p

artículo científico publicado en 2002

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

artículo científico publicado en 2014

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

article

Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

artículo científico publicado en 2009

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

artículo científico publicado en 2000

Genomic insights into the origin of farming in the ancient Near East

artículo científico publicado en 2016

Genotype-by-nutrient interactions assessed in European obese women

artículo científico publicado en 2006

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

artículo científico publicado en 2002

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene

artículo científico publicado en 1993

Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France

artículo científico publicado en 2002

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships

artículo científico publicado en 1993

Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene

artículo científico publicado en 1998

Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity

artículo científico publicado en 2012

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

artículo científico publicado en 2016

Hepatocyte Nuclear Factor-4 P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

artículo científico publicado en 2006

Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group

artículo científico publicado en 2008

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

artículo científico publicado en 2011

High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children

artículo científico publicado en 2017

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families.

artículo científico publicado en 2012

Highly sensitive diagnosis of 43 monogenic forms of diabetes or obesity through one-step PCR-based enrichment in combination with next-generation sequencing

artículo científico publicado en 2013

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

scientific article published on 14 May 2020

Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes

article

How Recent Advances in Genomics Improve Precision Diagnosis and Personalized Care of Maturity-Onset Diabetes of the Young

scientific article published on 05 August 2019

Human diabetes and obesity: tracking down the genes

artículo científico publicado en 1995

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease.

artículo científico publicado en 2008

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus ⬇️

artículo científico publicado el 15 de agosto de 1992

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

artículo científico publicado en 2011

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity

article

INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study

artículo científico publicado en 2008

ITIH-5 expression in human adipose tissue is increased in obesity.

artículo científico publicado en 2011

Identification de 4 nouveaux gènes à risque de diabète de type 2 modulant la fonction β pancréatique et l’insulino-sécrétion

artículo científico publicado en 2017

Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1.

artículo científico publicado en 2005

Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene

artículo científico publicado en 2011

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

artículo científico publicado en 2023

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

artículo científico publicado en 2013

Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients

artículo científico publicado en 2000

Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans

article

Identification of trinucleotide repeat-containing genes in human pancreatic islets

artículo científico publicado en 1996

Identification of trinucleotide repeat-containing genes in human pancreatic islets

article

Identification of two novel loss-of-function SIM1 mutations in two overweight children with developmental delay

artículo científico publicado en 2014

Impact of a CART promoter genetic variation on plasma lipid profile in a general population

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

artículo científico publicado en 2017

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study

artículo científico publicado en 2007

Impact of common variation in bone-related genes on type 2 diabetes and related traits

artículo científico publicado en 2012

Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

artículo científico publicado en 2016

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

artículo científico publicado en 2013

Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects

artículo científico publicado en 1996

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function

artículo científico publicado en 2016

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

artículo científico publicado en 2003

Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population

artículo científico publicado en 2005

Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors

artículo científico publicado en 2009

Improved protocol for laser microdissection of human pancreatic islets from surgical specimens

artículo científico publicado en 2013

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

artículo científico publicado en 2018

Indication for linkage of the human OB gene region with extreme obesity

artículo científico publicado en 1996

Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity

artículo científico publicado en 2013

Inferring combined CNV/SNP haplotypes from genotype data

artículo científico publicado en 2010

Inflammation is associated with a decrease of lipogenic factors in omental fat in women

artículo científico publicado en 2008

Inflammatory role of Toll-like receptors in human and murine adipose tissue

artículo científico publicado en 2010

Inputs from the genetics of fasting glucose: lessons for diabetes

artículo científico publicado en 2009

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus

artículo científico publicado en 1994

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

artículo científico publicado en 2009

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

artículo científico publicado en 2009

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

artículo científico publicado en 1991

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity

artículo científico publicado en 2004

Integration of clinical data with a genome-scale metabolic model of the human adipocyte

artículo científico publicado en 2013

Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study

artículo científico publicado en 2016

Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms

artículo científico publicado en 2012

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

artículo científico publicado en 2003

Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine

artículo científico publicado en 2010

Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants

artículo científico publicado en 2011

Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?

artículo científico publicado en 2005

Is obesity our genetic legacy?

artículo científico publicado en 2008

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease

artículo científico publicado en 2003

Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]

artículo científico publicado en 1994

Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose.

artículo científico publicado en 2018

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

artículo científico publicado en 2016

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

artículo científico publicado en 2012

Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients

artículo científico publicado en 2004

Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects

article

Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population

artículo científico publicado en 2007

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

artículo científico publicado en 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

artículo científico publicado en 2012

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Leptin Receptor Gene in a Large Cohort of Massively Obese Subjects: No Indication of the fa/fa Rat Mutation. Detection of an Intronic Variant with No Association with Obesity ⬇️

artículo científico publicado el 1 de marzo de 1998

Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women

artículo científico publicado en 2007

Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families

artículo científico publicado en 2000

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q

artículo científico publicado en 2009

Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

artículo científico publicado en 2008

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

artículo científico publicado en 2009

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

artículo científico publicado en 2018

Loss-of-function mutations in MC4R are very rare in the Greek severely obese adult population

artículo científico publicado en 2012

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension

artículo científico publicado en 2019

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features

artículo científico publicado en 2013

Low copy number of the salivary amylase gene predisposes to obesity.

artículo científico publicado en 2014

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

artículo científico publicado en 2017

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

artículo científico publicado en 2011

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue

artículo científico publicado en 2018

MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells

scientific article published on 20 October 2009

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

artículo científico publicado en 2010

Macrophage gene expression in adipose tissue is associated with insulin sensitivity and serum lipid levels independent of obesity.

artículo científico publicado en 2013

Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity

artículo científico publicado en 2000

Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA(Leu(UUR)) gene

artículo científico publicado en 1994

Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus

artículo científico publicado en 1997

Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986

artículo científico publicado en 2013

Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes

scientific article published on 13 July 2013

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

artículo científico publicado en 2000

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

artículo científico publicado en 2020

Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

article

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets

artículo científico publicado en 2010

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2010

Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle

artículo científico publicado en 2021

Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

artículo científico publicado en 2009

Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes

artículo científico publicado en 2007

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

artículo científico publicado en 2011

Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online

artículo científico publicado en 2007

Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.

artículo científico publicado en 2010

Molecular genetics of human obesity-associated MC4R mutations

artículo científico publicado en 2003

Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes

artículo científico publicado en 2008

Monogenic diabetes: Implementation of translational genomic research towards precision medicine

artículo científico publicado en 2016

Monogenic forms of diabetes mellitus: an update

scientific article published on December 2009

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

artículo científico publicado en 2019

Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition

artículo científico publicado en 2012

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels

artículo científico publicado en 2013

Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.

artículo científico publicado en 2010

Mutation screening in 18 Caucasian families suggest the existence of other MODY genes

article

Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease.

artículo científico publicado en 2000

Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians ⬇️

artículo científico publicado el 1 de mayo de 1998

Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

article

Mutations exomiques rares transmises au sein de familles de type MODY : analyse de corrélation avec la variabilité phénotypique et les défauts métaboliques précoces

artículo científico publicado en 2017

Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction

artículo científico publicado en 2009

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians

artículo científico publicado en 2003

NACHO: an R package for quality control of NanoString nCounter data

scientific article published on 01 February 2020

Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians

artículo científico publicado en 2001

Neonatal diabetes: a disease linked to multiple mechanisms

artículo científico publicado en 2007

Neonatal hyperglycaemia and abnormal development of the pancreas.

artículo científico publicado en 2008

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].

artículo científico publicado en 2013

New ABCC8 mutations in relapsing neonatal diabetes and clinical features

artículo científico publicado en 2007

New gene functions in megakaryopoiesis and platelet formation

artículo científico publicado en 2011

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

artículo científico publicado en 2012

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck ⬇️

artículo científico publicado el 29 de julio de 2013

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians

artículo científico publicado en 2002

No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases

article

No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France

article

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

artículo científico publicado en 2012

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects

article

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

article

Novel LEPR mutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing.

artículo científico publicado en 2013

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity

artículo científico publicado en 2012

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

artículo científico publicado en 2018

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

artículo científico publicado en 2020

O06 Le mutant perte de fonction p.R46L de PCSK9 n’est pas associé à un risque accru de diabète chez l’homme

artículo científico publicado en 2015

O2 L’extinction de la biosynthèse d’insuline via l’altération d’un site de fixation du facteur de transcription KLF11 entraîne une forme congénitale de diabète néonatal

artículo científico publicado en 2011

O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R

artículo científico publicado en 2014

O5 Des mutations du gène de la préproinsuline altèrent la maturation de l’insuline et entraînent un diabète non auto-immun chez l’enfant et de type Mody

artículo científico publicado en 2009

O5 La lysine acetyl-transferase P300/CBP-associated factor (PCAF) contrôle la sécrétion d’insuline et la réponse au stress du reticulum

artículo científico publicado en 2014

O50 La protéine P300/CBP-associated factor (PCAF) est une histone acetyl-transferase qui contrôle la fonction de la cellule ß pancréatique

artículo científico publicado en 2013

O52 L’activité enzymatique plasmatique de l’amylase pancréatique est associée à une diminution de l’indice de masse corporelle et protège du risque de diabète dans la cohorte D.E.S.I.R

artículo científico publicado en 2015

O53 L’altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l’Homme et la Souris

artículo científico publicado en 2012

O57 Des variations du nombre de copies au niveau d’un CNV fréquent contribuent très fortement au risque d’obésité

artículo científico publicado en 2012

O58 Une nouvelle cause curable de MODY et de DT2 de l’adulte jeune révélée par une mutation de KCNJ11, codant la sous-unité Kir6.2 du canal potassique ATP-dépendant

artículo científico publicado en 2012

O59 Identification de nouvelles mutations associées au diabète néonatal grâce à l’utilisation de techniques (pan) génomiques incluant le séquençage de nouvelle génération

artículo científico publicado en 2015

O61 Le diabète de type 2 est responsable d’anomalies chromosomiques somatiques en mosaïques qui sont pré-cancéreuses

artículo científico publicado en 2013

O9 L’Extinction de l’Activité du Promoteur du Gène de l’Insuline Entraîne une Forme Congénitale de Diabète Néonatal Transitoire

artículo científico publicado en 2010

O97 Des variants du gène MTNR1B du récepteur 2 à la mélatonine augmentent la glycémie et le risque de DT2 : un lien entre le rythme circadien et le diabète ?

artículo científico publicado en 2009

O98 Des variants du promoteur du gène G6PC2 pourraient expliquer la contribution de ce locus au contrôle génétique de la glycémie

artículo científico publicado en 2009

Obesity status modifies the association between rs7556897T>C in the intergenic region SLC19A3-CCL20 and blood pressure in French children

artículo científico publicado en 2020

Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women

artículo científico publicado en 2006

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study

artículo científico publicado en 2010

P128 Identification de nouveaux polymorphismes génétiques associés au risque de diabète de type 2 chez les obèses et non obèses européens

P202 Utilisation des cellules souches somatiques pour modéliser le diabète monogénique lié aux anomalies du canal potassique de KCNJ11

artículo científico publicado en 2015

P210 Nouvelles Approches dans l’Étude des Diabètes Monogéniques chez l’Enfant et l’Adulte Jeune, et Distribution des Étiologies Génétiques à partir de la Cohorte du Réseau d’Étude Français

artículo científico publicado en 2010

P222 Expression différentielle de transcrits alternatifs de TCF7L2 dans le foie humain diabétique, et leur induction par l’insuline dans les cellules hépatiques HepG2

PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population

artículo científico publicado en 2003

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

artículo científico publicado en 2016

PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women

artículo científico publicado en 2009

PO11 Deux nouveaux loci associés au diabète de type 2 dans la population mexicaine identifiés par les puces Metabochip

artículo científico publicado en 2015

PO13 Identification par séquençage de nouvelle génération de deux nouvelles mutations situées dans LEPR, chez des enfants pakistanais avec une obésité sévère et issus de familles consanguines

artículo científico publicado en 2014

PO27 Diagnostic moléculaire simultané de 43 formes monogéniques de diabète et d’obésité : un pas vers la médecine métabolique Personnalisée

artículo científico publicado en 2013

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes

artículo científico publicado en 1997

Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

artículo científico publicado en 2013

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

artículo científico publicado en 2020

Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes.

artículo científico publicado en 2013

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

artículo científico publicado en 2020

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

artículo científico publicado en 2011

Physiopathologie du diabète

artículo científico publicado en 2018

Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes

article

Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes.

artículo científico

Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians

artículo científico publicado en 2004

Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes

artículo científico publicado en 2006

Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes

artículo científico publicado en 2002

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

artículo científico publicado en 2008

Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis

artículo científico publicado en 2016

Preadipocyte response and impairment of differentiation in an inflammatory environment

artículo científico publicado en 2007

Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

artículo científico publicado en 2008

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans

artículo científico publicado en 2008

Prevalence of loss-of-function FTO mutations in lean and obese individuals

artículo científico publicado en 2009

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

artículo científico publicado en 2008

Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes

artículo científico publicado en 2002

Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young

artículo científico publicado en 1992

Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients

artículo científico publicado en 2000

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

article

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells

artículo científico publicado en 2014

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

artículo científico publicado en 2012

Rare and common genetic events in type 2 diabetes: what should biologists know?

artículo científico publicado en 2015

Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity

artículo científico publicado en 2013

Rare variants identified in the HNF-4α β-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes

article by S. Mitchell et al published 19 July 2002 in Diabetologia

Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.

artículo científico publicado en 2012

Recherche translationnelle : médecine personnalisée, médecine de précision, thérapies ciblées : marketing ou science ?

article by Pierre Marquet et al published January 2015 in Thérapie

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

artículo científico publicado en 2018

Reflections on the field of metabolism

artículo científico publicado en 2015

Regulation of carboxylesterase 1 (CES1) in human adipose tissue

artículo científico publicado en 2009

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

artículo científico publicado en 2017

Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.

artículo científico publicado en 2011

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

artículo científico publicado en 2007

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530.

artículo científico publicado en 2012

Response to the letter to the editor: “HIF-1α protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity,” by Trayhurn et al

Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions

artículo científico

Role of the DGAT Gene C79T Single‐Nucleotide Polymorphism in French Obese Subjects ⬇️

artículo científico publicado el 1 de octubre de 2003

Role of the unfolded protein response in β cell compensation and failure during diabetes

artículo científico publicado en 2014

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

artículo científico publicado en 2005

SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts

artículo científico publicado en 2004

Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS

artículo científico publicado en 2011

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

artículo científico publicado en 2007

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2017

Seventy-five genetic loci influencing the human red blood cell

artículo científico publicado en 2012

Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study

artículo científico publicado en 2009

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

artículo científico publicado en 2013

Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis.

artículo científico publicado en 2017

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

artículo científico publicado en 2007

Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects

article

Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects

artículo científico publicado en 2004

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians

artículo científico publicado en 2002

Small deletion variants have stable breakpoints commonly associated with alu elements.

artículo científico publicado en 2008

Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height

artículo científico publicado en 2009

Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.

artículo científico publicado en 2000

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

artículo científico publicado en 2012

Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids

article

Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants

scientific journal article

Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population

artículo científico publicado en 2010

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.

artículo científico publicado en 1993

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

artículo científico publicado en 2017

TCF7L2 genetic defect and type 2 diabetes

artículo científico publicado en 2008

TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia

artículo científico publicado en 2009

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

artículo científico publicado en 2007

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

artículo científico publicado en 2012

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

artículo científico publicado en 2007

TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet

artículo científico publicado en 2009

TCF7L2 splice variants have distinct effects on beta-cell turnover and function

artículo científico publicado en 2011

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

artículo científico publicado en 2006

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss

artículo científico publicado en 2009

The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients

artículo científico publicado en 1997

The Case | Hypokalemia and severe renal loss of sodium

scientific article published on 01 June 2020

The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm

artículo científico publicado en 2016

The EIF2AK3 gene region and type I diabetes in subjects from South India

artículo científico publicado en 2004

The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon

artículo científico publicado en 1996

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development

artículo científico publicado en 2020

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resi

artículo científico publicado en 2006

The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population

artículo científico publicado en 2008

The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects

artículo científico publicado en 2009

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate

artículo científico publicado en 2013

The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus

artículo científico publicado en 2004

The case for too little melatonin signalling in increased diabetes risk

artículo científico publicado en 2017

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

artículo científico publicado en 2008

The emerging genetics of type 2 diabetes

artículo científico publicado en 2010

The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward

artículo científico publicado en 2019

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

scientific journal article

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

artículo científico publicado en 2000

The genetic abnormality in the beta cell determines the response to an oral glucose load

artículo científico publicado en 2002

The genetic architecture of type 2 diabetes

artículo científico publicado en 2016

The genetic contribution to non-syndromic human obesity

artículo científico publicado en 2009

The genetic structure of the world's first farmers

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

artículo científico publicado en 2008

The genetics of adiponectin ⬇️

artículo científico publicado el 1 de abril de 2003

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

artículo científico publicado en 2016

The genetics of human obesity

artículo científico publicado en 2005

The genetics of non-insulin-dependent diabetes mellitus: tools and aims

artículo científico publicado en 1994

The genetics of non-insulin-dependent diabetes mellitus: tools and aims

article

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.

artículo científico publicado en 2009

The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size

artículo científico publicado en 2012

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

article

The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis

artículo científico

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

artículo científico publicado en 2015

The power of the extreme in elucidating obesity

artículo científico publicado en 2008

The trans-ancestral genomic architecture of glycemic traits

The unique clinical spectrum of maturity onset diabetes of the young type 3.

artículo científico publicado en 2017

TheFTOGene Is Associated With Adulthood Obesity in the Mexican Population

artículo científico publicado en 2008

TheINSVNTR Locus Does Not Associate with Smallness for Gestational Age (SGA) but Interacts with SGA to Increase Insulin Resistance in Young Adults

scholarly article by Thuy-Ai Vu-Hong et al published June 2006 in The Journal of Clinical Endocrinology and Metabolism

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

artículo científico publicado en 2016

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

article

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

artículo científico publicado en 2013

Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis

artículo científico publicado en 2019

Translational research: precision medicine, personalized medicine, targeted therapies: marketing or science?

artículo científico publicado en 2015

Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort.

artículo científico publicado en 2017

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone

article

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

artículo científico publicado en 2010

Two Caucasian Families with the Hepatocyte Nuclear Factor-1Alpha Mutation Tyr218Cys

Two Taql RFLPs at the GLUT2 locus in French Caucasian population ⬇️

artículo científico publicado el 25 de octubre de 1991

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

scientific journal article

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

artículo científico publicado en 2007

Type 2 diabetes-associated variants of the MT melatonin receptor affect distinct modes of signaling

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

artículo científico publicado en 2014

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

Understanding the rising incidence of type 2 diabetes in adolescence

artículo científico publicado en 2004

VNTR polymorphism of the insulin gene and childhood overweight in a general population

artículo científico publicado en 2004

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

artículo científico publicado en 2010

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

artículo científico publicado en 2005

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

article

Variation in FTO contributes to childhood obesity and severe adult obesity

artículo científico publicado en 2007

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.

artículo científico publicado en 2007

Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients

artículo científico publicado en 2014

What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

artículo científico publicado en 2015

What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

artículo científico publicado en 2013

Whole-exome sequencing and high throughput genotyping identified KCNJ11 as the thirteenth MODY gene

artículo científico publicado en 2012

[Adipocytokins, obesity and development of type 2 diabetes]. ⬇️

artículo científico publicado en 2003

[Obesity genes and their effect on the energy balance]

artículo científico publicado en 2015

[Something new in the genetics of monogenic obesity and its insights into pathophysiology]

scientific article published on 07 October 2020

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations

artículo científico publicado en 2001

cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs

artículo científico publicado en 2010

famCNV: copy number variant association for quantitative traits in families.

artículo científico publicado en 2011

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

artículo

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