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Lista de obras de Hugues Abriel

8th Ascona International Workshop on Cardiomyocyte Biology, 3-7 May, 2015 Integration of Developmental and Environmental Cues in the Heart Congressi Stefano Franscini, Monte Verità, Ascona, Switzerland

artículo científico publicado en 2016

A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes

artículo científico publicado en 2019

A modern approach to classify missense mutations in cardiac channelopathy genes

scientific article published on 01 October 2012

A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia.

artículo científico publicado en 2008

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

artículo científico publicado en 2013

A-Kinase Anchoring Protein Lbc Coordinates a p38 Activating Signaling Complex Controlling Compensatory Cardiac Hypertrophy.

artículo científico publicado en 2013

A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy

scientific journal article

Aldosterone increases voltage-gated sodium current in ventricular myocytes.

artículo científico publicado en 2006

Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome

artículo científico publicado en 2008

Annotation of functional impact of voltage-gated sodium channel mutations

artículo científico publicado en 2017

Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav 1.5 Sodium Channel.

artículo científico publicado en 2015

Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells.

artículo científico publicado en 2013

Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5.

artículo científico publicado en 2020

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

artículo científico publicado en 2011

Brugada Syndrome Unmasked by Accidental Inhalation of Gasoline Vapors

artículo científico publicado en 2007

Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine

artículo científico publicado en 2009

Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations.

artículo científico publicado en 2005

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.

scientific article published on 01 December 2020

Cardiac Sodium Current Under Sympathetic ControlProtein Phosphatase 2A Regulates Cardiac Na+ Channels

scientific article published on 01 March 2019

Cardiac channelopathies: genetic and molecular mechanisms.

artículo científico

Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology

artículo científico publicado en 2010

Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1

artículo científico publicado en 2006

Cardiac sodium channel Na(v)1.5 mechanosensitivity is inhibited by ranolazine.

artículo científico publicado en 2012

Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model

artículo científico

Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin.

artículo científico publicado en 2006

Cardiac voltage-gated calcium channel macromolecular complexes

artículo científico

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination

artículo científico publicado en 2004

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

scientific journal article

Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains

artículo científico publicado en 2009

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

artículo científico publicado en 2015

Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations

artículo científico publicado en 2002

Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias

artículo científico publicado en 2013

Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation

artículo científico publicado en 2006

Complex genetic background in a large family with Brugada syndrome

artículo científico publicado en 2015

Complexity of cardiac ion channel macromolecular complexes

artículo científico publicado en 2016

Computational tools to investigate genetic cardiac channelopathies.

artículo científico publicado en 2013

Correction: Mapping Genetic Variants Associated with Beta-Adrenergic Responses in Inbred Mice.

artículo científico publicado en 2014

Corrigendum: Transcriptomic analyses of murine ventricular cardiomyocytes

scholarly article published in Scientific Data

Crosstalk between cardiac ion channel subunits: an encrypted language to be deciphered

scientific article published on 03 June 2008

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

artículo científico publicado en 1999

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

artículo científico publicado en 2012

Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc

artículo científico publicado en 2017

Dynamic of ion channel expression at the plasma membrane of cardiomyocytes

artículo científico publicado en 2012

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain.

artículo científico publicado en 2013

Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter

scientific article published on 19 December 2019

Editorial: Ion Channel Trafficking and Cardiac Arrhythmias

artículo científico publicado en 2018

Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes

scientific article published on 03 December 2007

Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na v1.5 expressed in HEK293 cells.

artículo científico publicado en 2013

Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques

artículo científico publicado en 2014

Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes

artículo científico publicado en 2013

Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes

artículo científico publicado en 1999

Force-controlled patch clamp of beating cardiac cells

artículo científico publicado en 2015

Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability.

artículo científico publicado en 2018

Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice

scientific article published on 11 October 2019

Functional characterization of a novel SCN5A variant associated with long QT syndrome and sudden cardiac death

artículo científico publicado en 2019

Functional implications of a rare variant in the sodium channel β1B subunit (SCN1B) in a 5-month-old male sudden infant death syndrome case.

artículo científico publicado en 2018

Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies

artículo científico publicado en 2014

Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias

artículo científico publicado en 2014

Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells

scientific article published on 13 September 2018

Genetic background of Brugada syndrome is more complex than what we would like it to be!

artículo científico publicado en 2015

Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects

artículo científico publicado en 2014

ICEPO: the ion channel electrophysiology ontology

artículo científico publicado en 2016

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

scientific journal article

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

artículo científico publicado en 2018

Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes

artículo científico publicado en 2001

Inherited progressive cardiac conduction disorders

artículo científico publicado en 2015

Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death

artículo científico publicado en 2015

Ion transport across the early chick embryo: I. Electrical measurements, ionic fluxes and regional heterogeneity.

artículo científico publicado en 1994

Ion transport across the early chick embryo: II. Characterization and pH sensitivity of the transembryonic short-circuit current

artículo científico publicado en 1994

KChAP: a novel chaperone for specific K(+) channels key to repolarization of the cardiac action potential. Focus on "KChAP as a chaperone for specific K(+) channels"

scientific article published on 01 May 2000

Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes

scientific journal article

Late cardiac sodium current can be assessed using automated patch-clamp

artículo científico publicado en 2014

Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes.

artículo científico publicado en 2016

Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

artículo científico publicado en 2004

Male and female equality: still far from goal

artículo científico publicado en 2008

Mapping genetic variants associated with beta-adrenergic responses in inbred mice

artículo científico publicado en 2012

Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure.

artículo científico publicado en 2013

Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.

artículo científico publicado en 2007

Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules

artículo científico publicado en 2019

Modulation of Nav1.5 channel function by an alternatively spliced sequence in the DII/DIII linker region.

artículo científico publicado en 2006

Molecular and clinical determinants of drug-induced long QT syndrome: an iatrogenic channelopathy.

artículo científico publicado en 2004

Molecular autopsy in sudden cardiac death and its implication for families: discussion of the practical, legal and ethical aspects of the multidisciplinary collaboration

scientific article published on December 2009

Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients

artículo científico publicado en 2006

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

artículo científico publicado en 2004

Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel

artículo científico publicado en 2013

Na+ channel function, regulation, structure, trafficking and sequestration

artículo científico publicado en 2015

NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy.

artículo científico publicado en 2013

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

artículo científico publicado en 2011

Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding

artículo científico publicado en 2004

Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.

artículo científico publicado en 2016

Nervous and immune systems as targets for developmental effects of benzodiazepines. A review of recent studies

artículo científico publicado el 1 de enero de 1992

Neurohormonal regulation of cardiac ion channels in chronic heart failure

artículo científico publicado en 2009

Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain.

artículo científico publicado en 2012

Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels

artículo científico publicado en 2011

Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.

artículo científico publicado en 2001

Optimizing TRPM4 inhibitors in the MHFP6 chemical space

artículo científico publicado en 2019

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

artículo científico publicado en 2014

Patient with syncope and LQTS carrying a mutation in the PAS domain of the hERG1 channel.

artículo científico publicado en 2011

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes

artículo científico publicado en 2015

Prevalence of Significant Genetic Variants in Congenital Long QT Syndrome is Largely Underestimated.

artículo científico publicado en 2012

Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice.

artículo científico publicado en 2013

Refining the molecular organization of the cardiac intercalated disc

artículo científico publicado en 2017

Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.

artículo científico publicado en 2015

Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice

artículo científico publicado en 2010

Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4.

artículo científico publicado en 2000

Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins.

artículo científico publicado en 2005

Role of "non-cardiac" voltage-gated sodium channels in cardiac cells

artículo científico publicado en 2012

Role of the intracellular domain of the beta subunit in Na,K pump function

artículo científico publicado en 1999

Roles and regulation of the cardiac sodium channel Na v 1.5: recent insights from experimental studies.

artículo científico publicado en 2007

Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state

artículo científico publicado en 2013

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

artículo científico publicado en 2011

Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.

artículo científico publicado en 2010

Single-molecule Localization of Nav1.5 Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains

artículo científico publicado en 2020

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

artículo científico publicado en 2007

Stereoselective Inhibition of the hERG1 Potassium Channel.

artículo científico publicado en 2010

TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology.

artículo científico

Takotsubo cardiomyopathy and congenital long QT syndrome in a patient with a novel duplication in the Per-Arnt-Sim (PAS) domain of hERG1.

artículo científico publicado en 2009

Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I

article

Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task!

artículo científico publicado en 2014

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

artículo científico publicado en 2007

The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration

artículo científico publicado en 2018

Transcriptomic analyses of murine ventricular cardiomyocytes

scientific article published on 21 August 2018

Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels.

artículo científico publicado en 2014

Ubiquitylation and SUMOylation of cardiac ion channels

artículo científico publicado en 2010

Ubiquitylation of ion channels

artículo científico publicado en 2005

Ubiquitylation of voltage-gated sodium channels.

artículo científico publicado en 2014

Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via α-subunit interaction

artículo científico publicado en 2012

Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome

artículo científico publicado en 2014

Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model

artículo científico publicado en 2010

Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block

scientific journal article

Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A

artículo científico publicado en 2009

p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder.

artículo científico publicado en 2015

β-blockers in congenital short-QT syndrome as ion channel blockers.

artículo científico publicado en 2013

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells

artículo científico publicado en 2013