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A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat

artículo científico publicado en 2014

A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity.

artículo científico publicado en 2017

A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers

scientific article published on 11 May 2019

A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells.

artículo científico publicado en 2002

A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription

artículo científico publicado en 2014

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

artículo científico publicado en 2018

An Engineered Variant of the B1 Domain of Protein G Suppresses the Aggregation and Toxicity of Intra- and Extracellular Aβ42

scientific article published on 28 November 2018

Aβ42 Double Mutant Inhibits Aβ42-Induced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells

scientific article published on 20 March 2020

BMP5/7 protect dopaminergic neurons in an α -synuclein mouse model of Parkinson's disease

artículo científico publicado en 2020

CRISPRi-mediated depletion of Spt4 and Spt5 reveals a role for DSIF in the control of HIV latency

artículo científico publicado en 2020

Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element

scientific journal article

Efficient production of HIV-1 viral-like particles in mouse cells.

artículo científico publicado en 2008

Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes.

artículo científico publicado en 2015

Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1.

artículo científico publicado en 2012

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation

scientific article published on 25 June 2019

Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency

scientific article published on 21 September 2020

In vivo selection of CD4(+) T cells transduced with a gamma-retroviral vector expressing a single-chain intrabody targeting HIV-1 tat.

artículo científico publicado en 2012

Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes

artículo científico publicado en 2002

Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles

artículo científico publicado en 2008

Lost in transcription: molecular mechanisms that control HIV latency

artículo científico publicado en 2013

Measles Virus Persistent Infection of Human Induced Pluripotent Stem Cells

artículo científico publicado en 2018

Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin

artículo científico publicado en 2012

P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA

artículo científico publicado en 2002

Preferential lentiviral targeting of astrocytes in the central nervous system

artículo científico publicado en 2013

Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb

artículo científico publicado en 2017

The Fidelity of 3′ Misinsertion and Mispair Extension During DNA Synthesis Exhibited by two Drug‐Resistant Mutants of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 with Leu74→Val and Glu89→Gly

artículo científico publicado el 1 de julio de 1997

The Fidelity of Misinsertion and Mispair Extension Throughout DNA Synthesis Exhibited by Mutants of the Reverse Transcriptase of Human Immunodeficiency Virus Type 2 Resistant to Nucleoside Analogs

artículo científico publicado el 15 de noviembre de 1997

The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs

artículo científico publicado en 2013

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

scientific article published on 25 August 2020

ZNF750 is expressed in differentiated keratinocytes and regulates epidermal late differentiation genes

artículo científico publicado en 2012