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"End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?

artículo científico publicado en 2011

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

artículo científico publicado en 2016

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

artículo científico publicado en 2019

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

artículo científico publicado en 2004

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

artículo científico publicado en 2007

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

artículo científico publicado en 2014

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

artículo científico publicado en 2015

Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38

scientific article published on 01 January 2004

Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia

artículo científico publicado en 2013

Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene

artículo científico publicado en 2020

Alzheimer's Biomarkers are Correlated with Brain Connectivity in Older Adults Differentially during Resting and Task States.

artículo científico publicado en 2016

Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

artículo científico publicado en 2011

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation

artículo científico publicado en 2004

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

artículo científico publicado en 2004

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism ⬇️

artículo científico publicado el 12 de mayo de 1998

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release ⬇️

artículo científico publicado el 2 de marzo de 1998

Analysis of shared heritability in common disorders of the brain

artículo científico publicado en 2018

Analysis of the calcium-modulated proteins, S100 and calmodulin, and their target proteins during C6 glioma cell differentiation

artículo científico publicado en 1989

Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker

artículo científico publicado en 1999

Antisense approaches to the function of glial cell proteins

artículo científico publicado el 28 de octubre de 1992

Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation

scientific journal article

ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function

artículo científico publicado en 2004

Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses

artículo científico publicado en 2001

Apolipoprotein E attenuates beta-amyloid-induced astrocyte activation.

artículo científico publicado en 1998

Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures

artículo científico publicado en 2000

Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing

artículo científico publicado en 2013

Association between male gender and cortical Lewy body pathology in large autopsy series

artículo científico publicado en 2010

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

artículo científico publicado en 2015

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

artículo científico publicado en 2023

Barriers to Alzheimer disease drug discovery and development in academia

artículo científico publicado en 2002

Barriers to drug discovery and development for Alzheimer disease.

artículo científico publicado en 2002

Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease

artículo científico publicado en 2013

Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia

scientific article published on 01 January 2019

Brain arteriolosclerosis

artículo científico publicado en 2020

Brain pathologies in extreme old age.

artículo científico publicado en 2015

Brain structure changes over time in normal and mildly impaired aged persons

artículo científico publicado en 2020

Brainstem Imaging in Alzheimer's Disease: Potential for Biomarker Development

article

Calcium-binding proteins and the molecular basis of calcium action.

artículo científico publicado en 1982

Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine

artículo científico publicado en 1981

Calmodulin, calbindin-D28K and calretinin in rat and chicken pineal glands: Immunocytochemical and immunoblotting analysis

article

Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease

artículo científico publicado en 2001

Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

artículo científico

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

artículo científico publicado en 2013

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

artículo científico publicado en 2015

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.

artículo científico

Comparative biochemistry of calmodulins and calmodulin-like proteins

scientific article published on 01 January 1980

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

artículo científico publicado en 2013

Conditions for reproducible detection of calmodulin and S100 beta in immunoblots

artículo científico publicado en 1984

Copper-dependent formation of disulfide-linked dimer of S100B protein

artículo científico publicado en 2000

Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction"

artículo científico publicado en 2020

Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells

artículo científico publicado en 2000

De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders

artículo científico publicado en 2006

Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models

artículo científico publicado en 2013

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice

article

Delivering probes and clinical candidates to test precision medicine therapeutic hypotheses

artículo científico publicado en 2021

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

artículo científico publicado en 2013

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

artículo científico publicado en 2006

Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease

artículo científico publicado en 2016

Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation.

artículo científico publicado en 2005

Differential regulation of S100 beta and mRNAs coding for S100-like proteins (42A and 42C) during development and after lesion of rat sciatic nerve

artículo científico publicado en 1991

Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques

artículo científico publicado en 2018

Diffuse brain injury induces acute post-traumatic sleep

artículo científico publicado en 2014

Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge

artículo científico publicado en 2016

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

artículo científico publicado en 2002

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's

artículo científico publicado en 2003

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses

artículo científico publicado en 2002

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

artículo científico publicado en 2015

Disulfide-linked S100 beta dimers and signal transduction

artículo científico publicado el 10 de noviembre de 1992

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology ⬇️

artículo científico publicado el 25 de julio de 2012

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

artículo científico publicado en 2020

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

artículo científico publicado en 2014

Elucidation of a minimal immunoreactive site of vertebrate calmodulin

artículo científico publicado en 1983

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

artículo científico publicado en 2009

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

artículo científico publicado en 2005

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

artículo científico publicado en 2005

Factors Associated with Unmet Needs among African-American Dementia Care Providers

artículo científico publicado en 2016

First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers

artículo científico publicado en 2020

Generation and behavior characterization of CaMKIIβ knockout mice

artículo científico publicado en 2014

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia

artículo científico publicado en 2019

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

artículo científico publicado en 2019

Glia and Alzheimer's disease.

artículo científico publicado en 2001

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

artículo científico publicado en 2006

Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches

artículo científico publicado en 2007

Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation

artículo científico publicado en 2007

Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation

artículo científico publicado en 1999

Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons

scientific article published on 12 March 2016

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature

artículo científico publicado en 2015

Hippocampal sclerosis in advanced age: clinical and pathological features.

artículo científico publicado en 2011

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

artículo científico publicado en 2013

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

artículo científico publicado en 2006

Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease.

artículo científico publicado en 1996

Identification of the binding site on S100B protein for the actin capping protein CapZ.

artículo científico publicado en 1997

Immunohistochemical localization of S100 beta in human nervous system tumors by using monoclonal antibodies with specificity for the S100 beta polypeptide

artículo científico publicado en 1986

Immunoreactive levels of myosin light-chain kinase in normal and virus-transformed chicken embryo fibroblasts.

artículo científico publicado en 1984

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

artículo científico publicado en 2004

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

artículo científico publicado en 1996

Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia

artículo científico publicado en 2004

Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected].

artículo científico publicado en 2009

Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug

artículo científico publicado en 2008

Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.

artículo científico publicado en 2014

Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100 beta

scientific article published on 01 September 1994

Interaction of calmodulin and other calcium-modulated proteins with gap junctions

scientific article published on 01 January 1987

Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins

scientific article published on 01 January 1985

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

artículo científico publicado en 2005

Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation

artículo científico publicado en 2001

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

artículo científico publicado en 2006

Ion-binding properties of recombinant S100β and two derivatives with either an inactivated Ca2+ site II or a normalized Ca2+ site I ⬇️

artículo científico publicado el 5 de diciembre de 1997

Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates

scientific article published on 01 January 1980

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

artículo científico publicado en 2013

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

artículo científico publicado en 2001

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

artículo científico publicado en 2008

MFG-E8 regulates microglial phagocytosis of apoptotic neurons

artículo científico publicado en 2008

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

artículo científico publicado en 2016

Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB.

artículo científico publicado en 2001

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

artículo científico publicado en 2011

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

artículo científico publicado en 2011

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease

scientific article published on 17 September 2020

Mild cognitive impairment: statistical models of transition using longitudinal clinical data

artículo científico publicado en 2012

Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

artículo científico publicado en 2000

Multiple gene products are produced from a novel protein kinase transcription region.

artículo científico publicado en 1995

Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain

artículo científico publicado en 2004

Nascent Astrocyte Particles Differ from Lipoproteins in CSF ⬇️

artículo científico publicado el 1 de mayo de 1998

Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues

artículo científico publicado en 1989

Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin

artículo científico publicado en 2014

Neuroinflammation: a potential therapeutic target

artículo científico publicado en 2005

Neurotrophic protein S100 beta stimulates glial cell proliferation

artículo científico publicado en 1991

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis ⬇️

artículo científico publicado en 2020

Organization of the genetic locus for chicken myosin light chain kinase is complex: Multiple proteins are encoded and exhibit differential expression and localization ⬇️

artículo científico publicado el 1 de septiembre de 1998

Overexpression of the neurotrophic cytokine S100 beta in human temporal lobe epilepsy

artículo científico publicado en 1995

P1‐097: TRAUMATIC BRAIN INJURY IN A MOUSE MODEL OF ALZHEIMER'S DISEASE LEADS TO PERSISTENT GLIAL ACTIVATION, CHRONIC PROINFLAMMATORY PHENOTYPE, AND INCREASED COGNITIVE DEFICITS

artículo científico publicado en 2014

Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease

artículo científico publicado en 2016

Perturbation of the calmodulin system in transformed cells

artículo científico publicado en 1990

Preclinical AD Workgroup staging: pathological correlates and potential challenges.

artículo científico publicado en 2011

Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition

artículo científico publicado en 2011

Preparation and use of iodinated calmodulin for studies of calmodulin-binding proteins

scientific article published on 01 January 1988

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

scientific article published on 22 June 2020

Production and characterization of monoclonal antibodies with specificity for the S100 beta polypeptide of brain S100 fractions ⬇️

artículo científico publicado el 1 de octubre de 1984

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

artículo científico publicado en 2003

Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography

scientific article published on 01 March 1980

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

artículo científico publicado en 2017

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

artículo científico publicado en 2015

Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes

artículo científico publicado en 2002

Reproducible production and characterization of anti-calmodulin antisera

scientific article published on 01 January 1980

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.

artículo científico publicado en 2017

Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

artículo científico publicado en 2016

S100 beta and serotonin: a possible astrocytic-neuronal link to neuropathology of Alzheimer's disease

artículo científico publicado el 1 de enero de 1992

S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions.

artículo científico publicado en 1994

S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures

artículo científico publicado en 1998

S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway

artículo científico publicado en 1996

S100 beta protects hippocampal neurons from damage induced by glucose deprivation

artículo científico publicado en 1995

S100 beta stimulates calcium fluxes in glial and neuronal cells ⬇️

artículo científico publicado el 15 de mayo de 1992

S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes

artículo científico publicado en 1996

S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia

artículo científico publicado en 2001

S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors

artículo científico publicado en 2005

S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes ⬇️

artículo científico publicado el 1 de diciembre de 1997

Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

artículo científico publicado en 1999

Selective modulation of BV-2 microglial activation by prostaglandin E(2). Differential effects on endotoxin-stimulated cytokine induction

artículo científico publicado en 1999

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.

artículo científico publicado en 2016

Self-Reported Memory Complaints: A Comparison of Demented and Unimpaired Outcomes

artículo científico publicado en 2016

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort

artículo científico publicado en 2014

Self-reported memory complaints: implications from a longitudinal cohort with autopsies

artículo científico publicado en 2014

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

artículo científico publicado en 2018

Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands

artículo científico publicado en 2001

Spinach calmodulin: isolation, characterization, and comparison with vertebrate calmodulins

scientific article published on 01 December 1980

Structure and enzymology of a death-associated protein kinase

artículo científico publicado en 2002

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

artículo científico publicado en 2008

TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase ⬇️

artículo científico publicado el 1 de julio de 1998

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

artículo científico publicado en 2014

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

artículo científico publicado en 2012

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

artículo científico publicado en 2015

Targeting innate immunity for neurodegenerative disorders of the central nervous system

artículo científico publicado en 2016

Targeting protein kinases in central nervous system disorders

artículo científico publicado en 2009

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

artículo científico publicado en 2017

The C-terminus and linker region of S100B exert dual control on protein-protein interactions with TRTK-12.

artículo científico publicado en 2002

The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer's Disease

artículo científico publicado en 2016

The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain

artículo científico publicado en 2003

The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review

artículo científico publicado en 2020

The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS ⬇️

artículo científico publicado el 24 de septiembre de 2010

The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target

artículo científico publicado en 2008

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

artículo científico publicado en 2014

The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.

artículo científico publicado en 2013

The roles of inflammation and immune mechanisms in Alzheimer's disease

artículo científico publicado en 2016

The solution structure of the bovine S100B protein dimer in the calcium-free state

artículo científico publicado en 1996

Tissue distribution of rat S100 alpha and S100 beta and S100-binding proteins

artículo científico publicado en 1987

Transcriptional regulation of the human S100 beta gene

artículo científico publicado en 1997

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton

artículo científico publicado en 1999

University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology

artículo científico publicado en 2012

Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity

artículo científico publicado en 1990

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

artículo científico publicado en 2014

Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model

artículo científico publicado en 2005

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

artículo científico publicado en 2014

[Penetrating peptide inhibitor of the myosin light chain kinase suppresses hyperpermeability of vascular endothelium].

artículo científico publicado en 2009

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