Lista de obras -

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol

artículo científico publicado en 2018

A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria

artículo científico publicado en 2020

A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS

scientific article published on 08 March 2018

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

artículo científico publicado en 2018

Alfuzosin delays cardiac repolarization by a novel mechanism

artículo científico publicado en 2007

An estimate of the number of hepatocyte donors required to provide reasonable estimates of human hepatic clearance from in vitro experiments

scientific article published on 01 April 2007

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

scholarly article

Classification and Regression Tree (CART) analysis to predict influenza in primary care patients

artículo científico publicado en 2016

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

artículo científico publicado en 2017

Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivat

artículo científico publicado en 2021

Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor

artículo científico publicado en 2013

Determination of Eligibility for Influenza Research: A Clinical Informatics Approach

scientific article published on 10 June 2019

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), etc.

artículo científico publicado en 2016

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

artículo científico publicado en 2015

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators.

artículo científico publicado en 2017

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

scientific article published on 13 September 2020

Disposition of PF-07321332 (Nirmatrelvir), an Orally Bioavailable Inhibitor of SARS-CoV-2 3CL Protease, across Animals and Humans

artículo científico publicado en 2022

Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder

artículo científico publicado en 2007

Estimation of the Effect of OAT2-Mediated Active Uptake on Meloxicam Exposure in the Human Liver

artículo científico publicado en 2020

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

artículo científico publicado en 2012

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement

artículo científico publicado en 2012

In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor

artículo científico publicado en 2017

In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes

artículo científico publicado en 2013

Influenza Vaccine Intention After a Medically Attended Acute Respiratory Infection

artículo científico publicado en 2018

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia / Cholestasis

artículo científico publicado en 2016

Intention to receive influenza vaccine after an acute respiratory illness

artículo científico publicado en 2015

In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.

artículo científico publicado en 2016

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

artículo científico publicado en 2017

Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1

artículo científico publicado en 2019

Mechanistic Insights on Clearance and Inhibition Discordance between Liver Microsomes and Hepatocytes When Clearance in Liver Microsomes Is Higher than in Hepatocytes

artículo científico publicado en 2020

Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.

artículo científico publicado en 2014

Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D).

artículo científico publicado en 2004

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

artículo científico publicado en 2018

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

artículo científico publicado en 2012

Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey

artículo científico publicado en 2021

Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma

artículo científico publicado en 2011

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides.

artículo científico publicado en 2015

Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs

artículo científico publicado en 2014

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

artículo científico publicado en 2021

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs

scientific article published on 28 September 2020

Proposed Clinical Indicators for Efficient Screening and Testing for COVID-19 Infection from Classification and Regression Trees (CART) Analysis

artículo científico publicado en 2020

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor

artículo científico publicado en 2013

Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides

artículo científico publicado en 2014

Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

artículo científico publicado en 2016

Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes

artículo científico publicado en 2021

Statistical methods for analysis of time-dependent inhibition of cytochrome p450 enzymes

artículo científico publicado en 2012

The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

artículo científico publicado en 2016

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast

artículo científico publicado en 2016

Undesired versus designed enzymatic cleavage of linkers for liver targeting

artículo científico publicado en 2014

Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes.

artículo científico publicado en 2016

Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season

artículo científico publicado en 2015

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

artículo científico publicado en 2010

Viral infections in outpatients with medically attended acute respiratory illness during the 2012-2013 influenza season

artículo científico publicado en 2015

Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project

artículo científico publicado en 2004

Lista de obras de

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol

A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria

A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Alfuzosin delays cardiac repolarization by a novel mechanism

An estimate of the number of hepatocyte donors required to provide reasonable estimates of human hepatic clearance from in vitro experiments

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Classification and Regression Tree (CART) analysis to predict influenza in primary care patients

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue

Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivat

Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor

Determination of Eligibility for Influenza Research: A Clinical Informatics Approach

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), etc.

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators.

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

Disposition of PF-07321332 (Nirmatrelvir), an Orally Bioavailable Inhibitor of SARS-CoV-2 3CL Protease, across Animals and Humans

Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder

Estimation of the Effect of OAT2-Mediated Active Uptake on Meloxicam Exposure in the Human Liver

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement

In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor

In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes

Influenza Vaccine Intention After a Medically Attended Acute Respiratory Infection

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia / Cholestasis

Intention to receive influenza vaccine after an acute respiratory illness

In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1

Mechanistic Insights on Clearance and Inhibition Discordance between Liver Microsomes and Hepatocytes When Clearance in Liver Microsomes Is Higher than in Hepatocytes

Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.

Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D).

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey

Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides.

Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs

Proposed Clinical Indicators for Efficient Screening and Testing for COVID-19 Infection from Classification and Regression Trees (CART) Analysis

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor

Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides

Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes

Statistical methods for analysis of time-dependent inhibition of cytochrome p450 enzymes

The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast

Undesired versus designed enzymatic cleavage of linkers for liver targeting

Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes.

Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

Viral infections in outpatients with medically attended acute respiratory illness during the 2012-2013 influenza season

Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project