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(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation

artículo científico publicado en 2015

(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats

artículo científico publicado en 2012

3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner.

artículo científico publicado en 2017

A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors ⬇️

artículo científico publicado el 11 de abril de 2012

A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans

artículo científico publicado en 2004

A novel and facile preparation of bremazocine enantiomers through optically pure N-norbremazocines

artículo científico publicado en 2004

A novel vaccine that blunts fentanyl effects and sequesters ultrapotent fentanyl analogs

artículo científico publicado en 2020

A rapid solution-based method for determining the affinity of heroin hapten-induced antibodies to heroin, its metabolites, and other opioids

artículo científico publicado en 2018

A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain

artículo científico publicado en 2020

Activation of G-Proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated Metabolites at μ- and δ-Opioid Receptors ⬇️

artículo científico publicado el 4 de noviembre de 2003

Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats

artículo científico publicado en 2011

Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys

artículo científico publicado en 2017

Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling

artículo científico publicado en 2014

Amphetamine-Like Neurochemical and Cardiovascular Effects of a -Ethylphenethylamine Analogs Found in Dietary Supplements

artículo científico publicado en 2020

Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood

artículo científico publicado en 2017

Antagonism of sigma-1 receptors blocks compulsive-like eating

artículo científico publicado en 2012

Application of receptor theory to the design and use of fixed-proportion mu-opioid agonist and antagonist mixtures in rhesus monkeys

artículo científico publicado en 2018

Behavioral economic analysis of the reinforcing effects of "bath salts" mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats

artículo científico publicado en 2018

Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity

artículo científico publicado en 2007

CRF system recruitment mediates dark side of compulsive eating

artículo científico publicado en 2009

CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food.

artículo científico publicado en 2013

Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation

scientific article published on 27 February 2018

Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior.

artículo científico publicado en 2014

Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

scientific article published on January 2014

Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist

article published in the Proceedings of the National Academy of Sciences of the United States of America

Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats

artículo científico publicado en 2018

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

artículo científico publicado en 2006

Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats

artículo científico publicado en 2009

DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods

artículo científico publicado en 2006

Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity

artículo científico publicado en 2006

Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.

artículo científico publicado en 2009

Discriminative Stimulus Effects of the GABAB Receptor-Positive Modulator rac-BHFF: Comparison with GABAB Receptor Agonists and Drugs of Abuse ⬇️

artículo científico publicado el 28 de diciembre de 2012

Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys

artículo científico publicado en 2007

Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.

artículo científico publicado en 2018

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.

artículo científico publicado en 2006

Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.

artículo científico publicado en 2013

Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats

artículo científico publicado en 2019

Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses.

artículo científico publicado en 2012

Effects of Peripherally Restricted κ Opioid Receptor Agonists on Pain-Related Stimulation and Depression of Behavior in Rats ⬇️

artículo científico publicado el 29 de noviembre de 2011

Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys

artículo científico publicado en 2018

Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys

artículo científico publicado en 2011

Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging

artículo científico publicado en 2004

Effects of orally self-administered bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice

artículo científico publicado en 2017

Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains

artículo científico publicado en 2006

Effects of the Delta Opioid Receptor Agonist SNC80 on Pain-Related Depression of Intracranial Self-Stimulation (ICSS) in Rats ⬇️

artículo científico publicado el 15 de marzo de 2012

Effects of the GABAB Receptor-Positive Modulators CGP7930 and rac-BHFF in Baclofen- and γ-Hydroxybutyrate-Discriminating Pigeons ⬇️

artículo científico publicado el 7 de febrero de 2012

Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male mice

scientific article published on 15 July 2019

Escalated Alcohol Self-Administration and Sensitivity to Yohimbine-Induced Reinstatement in Alcohol Preferring Rats: Potential Role of Neurokinin-1 Receptors in the Amygdala

scientific article published on 23 June 2019

Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors

artículo científico publicado en 2008

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

artículo científico publicado en 2010

Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone

scientific article published on 06 September 2020

Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia

artículo científico publicado en 2011

Extracellular esterase activity as an indicator of endoplasmic reticulum calcium depletion

artículo científico publicado en 2018

Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter

artículo científico publicado en 2003

GABAB Receptor-Positive Modulators: Brain Region-Dependent Effects ⬇️

artículo científico publicado el 27 de septiembre de 2011

GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo

artículo científico publicado en 2010

Glial TLR4 signaling does not contribute to opioid-induced depression of respiration

artículo científico publicado en 2014

Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain

artículo científico publicado en 2013

High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver.

artículo científico publicado en 2017

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice ⬇️

artículo científico publicado en 2012

Inhibition of cocaine and 3,4-methylenedioxypyrovalerone (MDPV) self-administration by lorcaserin is mediated by 5-HT2C receptors in rats

artículo científico publicado en 2017

Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala

artículo científico publicado en 2014

Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys

artículo científico publicado en 2017

Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems

scientific article published on 30 April 2019

Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell

scientific article published on 17 July 2019

Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HT₂A receptor agonists: antinociception, drug discrimination, and locomotor activity

artículo científico publicado en 2012

Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study

artículo científico publicado en 2017

Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury

artículo científico publicado en 2016

Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors

artículo científico publicado en 2020

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

artículo científico publicado en 2016

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

artículo científico publicado en 2008

Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth

artículo científico publicado en 2016

Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward

artículo científico publicado en 2007

Persistent antagonism of methamphetamine-induced dopamine release in rats pretreated with GBR12909 decanoate

artículo científico publicado en 2002

Pharmacological characterization of the 20% alcohol intermittent access model in Sardinian alcohol-preferring rats: a model of binge-like drinking.

artículo científico publicado en 2012

Pharmacological mechanisms underlying the cardiovascular effects of the "bath salt" constituent 3,4-methylenedioxypyrovalerone (MDPV).

artículo científico publicado en 2016

Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter

artículo científico publicado en 2002

Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.

artículo científico publicado en 2018

Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats

scientific article published on 24 November 2020

Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence

artículo científico publicado en 2002

Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala

artículo científico publicado en 2009

Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols

artículo científico publicado en 2015

Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans

scientific article published on December 2009

Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans

artículo científico publicado en 2011

Probes for narcotic receptor mediated phenomena. 47.1 Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols ⬇️

artículo científico publicado el 3 de abril de 2013

Probes for narcotic receptor mediated phenomena. Part 28: new opioid antagonists from enantiomeric analogues of 5-(3-hydroxyphenyl)-N-phenylethylmorphan

artículo científico publicado en 2002

Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis

artículo científico publicado en 2009

Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats

artículo científico publicado en 2017

Reinforcing Effects of Binary Mixtures of Common Bath Salt Constituents: Studies with 3,4-Methylenedioxypyrovalerone (MDPV), 3,4-Methylenedioxymethcathinone (Methylone), and Caffeine in Rats

artículo científico publicado en 2017

Reinforcing effects of abused 'bath salts' constituents 3,4-methylenedioxypyrovalerone and α-pyrrolidinopentiophenone and their enantiomers

artículo científico publicado en 2017

Relative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats

artículo científico publicado en 2017

Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats

scientific article published on 01 October 2019

Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala

artículo científico publicado en 2013

Role of BNST CRFR1 Receptors in Incubation of Fentanyl Seeking

artículo científico publicado en 2020

Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys

artículo científico publicado en 2018

Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain

artículo científico publicado en 2014

Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys

scientific article published on 26 July 2019

Sensitization to the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA)

artículo científico publicado en 2019

Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates

artículo científico publicado en 2013

Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats

scientific article published on 12 December 2019

Sex differences in α-pyrrolidinopentiophenone (α-PVP)-induced taste avoidance, place preference, hyperthermia and locomotor activity in rats

scientific article published on 21 August 2019

Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats.

artículo científico publicado en 2015

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

artículo científico publicado en 2019

Stereoselective effects of the second-generation synthetic cathinone α-pyrrolidinopentiophenone (α-PVP): assessments of conditioned taste avoidance in rats

artículo científico publicado en 2018

Stereoselective neurochemical, behavioral, and cardiovascular effects of α-pyrrolidinovalerophenone enantiomers in male rats

scientific article published on 13 November 2019

Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.

artículo científico publicado en 2011

Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists

artículo científico publicado en 2015

Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine

artículo científico publicado en 2003

Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter

artículo científico publicado en 2006

Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice

artículo científico publicado en 2002

Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter

artículo científico publicado en 2005

Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists

artículo científico publicado en 2020

Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.

artículo científico publicado en 2017

Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters

artículo científico publicado en 2004

Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA.

scientific article published on October 2008

Synthesis of a Deuterated 6-AmHap Internal Standard for the Determination of Hapten Density in a Heroin Vaccine Drug Product

scientific article published on 02 September 2020

Synthesis of rac-(1R,4aR,9aR)-2-methyl-1,3,4,9a-tetrahydro-2H-1,4a-propanobenzofuro[2,3-c]pyridin-6-ol. An unusual double rearrangement leading to the ortho- and para-f oxide-bridged phenylmorphan isomers

artículo científico publicado en 2004

Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain

scientific article published on 09 January 2014

Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats

scientific article published on 16 February 2013

Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury

scientific article published on 14 April 2020

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4.

artículo científico

The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

artículo científico publicado en 2009

The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats.

artículo científico publicado en 2007

The NK1 receptor antagonist L822429 reduces heroin reinforcement

artículo científico publicado en 2012

The Supplement Adulterant β-Methylphenethylamine Increases Blood Pressure by Acting at Peripheral Norepinephrine Transporters

scientific article published on 21 March 2019

The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter

artículo científico publicado en 2018

The adrenergic receptor antagonist carvedilol interacts with serotonin 2A receptors both in vitro and in vivo

artículo científico publicado en 2019

The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors

artículo científico publicado en 2005

The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle.

artículo científico publicado en 2017

The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food.

artículo científico publicado en 2013

The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models

scientific article published on 03 May 2018

The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking

artículo científico publicado en 2013

The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking

artículo científico publicado en 2009

The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats

artículo científico publicado en 2020

Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice

artículo científico publicado en 2015

Toll-Like Receptor-4 Antagonist (+)-Naloxone Confers Sexually Dimorphic Protection From Inflammation-Induced Fetal Programming in Mice

scientific article published on 01 November 2019

Toll-Like Receptor-4 Antagonist (+)-Naltrexone Protects Against Carbamyl-Platelet Activating Factor (Cpaf)-Induced Preterm Labor in Mice

scientific article published on 18 February 2020

Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalitis (EAE)-related pain

artículo científico publicado en 2020

Twinned 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenyl)propyl)piperazinium chloride (GBR12909)

Z and E rotamers of N‐formyl‐1‐bromo‐4‐hydroxy‐3‐methoxymorphinan‐6‐one and their interconversion as studied by 1H/13C NMR spectroscopy and quantum chemical calculations ⬇️

artículo científico publicado el 11 de diciembre de 2012

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