Author response: Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters

Author response: The dynamic nature of the human origin recognition complex revealed through five cryoEM structures

Author response: The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

Cyclin binding Cy motifs have multiple activities in the initiation of DNA replication

Decision letter: A helicase-tethered ORC flip enables bidirectional helicase loading

Decision letter: Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

Decision letter: CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

Decision letter: Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

Decision letter: Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair

Decision letter: Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

Decision letter: Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Decision letter: Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Decision letter: Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

Decision letter: The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

Decision letter: The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

Decision letter: The role of Rif1 in telomere length regulation is separable from its role in origin firing

Editor's evaluation: A helicase-tethered ORC flip enables bidirectional helicase loading

Editor's evaluation: A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function

Editor's evaluation: A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

Editor's evaluation: Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair

Editor's evaluation: Drosophila SUMM4 complex couples insulator function and DNA replication control

Evolution of DNA Replication Origin Specification and Gene Silencing Mechanisms

Genome sequence assembly and annotation of MATA and MATB strains of Yarrowia lipolytica

The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures

The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure