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"Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution

artículo científico publicado en 2020

6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport

artículo científico publicado en 2007

A View Beyond HbA1c: Role of Continuous Glucose Monitoring.

artículo científico publicado en 2019

A controlled trial of CPAP therapy on metabolic control in individuals with impaired glucose tolerance and sleep apnea

artículo científico publicado en 2012

A new Michaelis–Menten‐based kinetic model for transport and phosphorylation of glucose and its analogs in skeletal muscle ⬇️

artículo científico publicado el 1 de agosto de 2011

Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial—Clinical Implications ⬇️

artículo científico publicado el 25 de octubre de 2010

Adverse Effects of Glycemia-Lowering Medications in Type 2 Diabetes

artículo científico publicado en 2019

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan ⬇️

artículo científico publicado el 1 de marzo de 2011

American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan: Executive Summary ⬇️

artículo científico publicado el 1 de marzo de 2011

American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control

artículo científico publicado en 2009

American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control.

artículo científico publicado en 2009

An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design

artículo científico publicado en 2010

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

artículo científico publicado en 2017

Analysis of metabolism of 6FDG: a PET glucose transport tracer ⬇️

artículo científico publicado el 3 de marzo de 2011

Antidepressant response associated with pioglitazone: support for an overlapping pathophysiology between major depression and metabolic syndrome

artículo científico publicado en 2009

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

artículo científico publicado en 2014

Association of Fenofibrate Therapy With Long-term Cardiovascular Risk in Statin-Treated Patients With Type 2 Diabetes

artículo científico

Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial.

artículo científico publicado en 2016

Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative

artículo científico publicado en 2014

Challenging Issues in the Management of Cardiovascular Risk Factors in Diabetes During the COVID-19 Pandemic: A Review of Current Literature

artículo científico publicado en 2020

Clinical practice. Glycemic management of type 2 diabetes mellitus

artículo científico publicado en 2012

Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients.

artículo científico publicado en 2011

Comparisons of different insulin infusion protocols: a review of recent literature

scientific article published on March 2010

Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin

artículo científico publicado en 2020

Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1.

artículo científico publicado en 2005

Control of Na+-K+-ATPase beta 1-subunit expression: role of 3'-untranslated region

scientific article published on 01 March 2004

Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation

scientific article published on 30 August 2006

DEXAMETHASONE STRESS TEST: A PILOT CLINICAL STUDY FOR IDENTIFICATION OF INDIVIDUALS HIGHLY PRONE TO DEVELOP TYPE 2 DIABETES

artículo científico publicado en 2018

Depressive symptoms and diabetes

artículo científico publicado en 2008

Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

artículo científico publicado en 2009

Determinants of Weight Gain in the Action to Control Cardiovascular Risk in Diabetes Trial ⬇️

artículo científico publicado el 14 de febrero de 2013

Determinants of glycemic control: Phase 2 analysis from nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2018)

artículo científico publicado en 2019

Determinants of successful glycemic control among participants in the BARI 2D trial: a post-hoc analysis

artículo científico publicado en 2013

Dexamethasone-induced insulin resistance: kinetic modeling using novel PET radiopharmaceutical 6-deoxy-6-[(18)F]fluoro-D-glucose

artículo científico publicado en 2014

Diabetes in Iran: Prospective Analysis from First Nationwide Diabetes Report of National Program for Prevention and Control of Diabetes (NPPCD-2016).

artículo científico publicado en 2017

Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial

artículo científico publicado en 2012

Differential accumulation of Glut1 in the non-DRM domain of the plasma membrane in response to the inhibition of oxidative phosphorylation

artículo científico publicado en 2004

Distribution of Glut1 in detergent-resistant membranes (DRMs) and non-DRM domains: effect of treatment with azide

artículo científico publicado en 2003

Disturbances in Insulin-Glucose Metabolism in Patients With Advanced Renal Disease With and Without Diabetes

scientific article published on 01 November 2019

Durable change in glycaemic control following intensive management of type 2 diabetes in the ACCORD clinical trial

artículo científico publicado en 2014

Effect of Dexamethasone on Glucose Homeostasis In Normal and Prediabetic Subjects With A First-Degree Relative With Type 2 Diabetes Mellitus ⬇️

artículo científico publicado el 1 de noviembre de 2012

Effect of dexamethasone on insulin secretion: examination of underlying mechanisms

artículo científico publicado en 2010

Effect of dexamethasone on oral glucose tolerance in healthy adults

artículo científico publicado en 2010

Effect of hypoglycemia on brain structure in people with type 2 diabetes: epidemiological analysis of the ACCORD-MIND MRI trial

artículo científico publicado en 2014

Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial

artículo científico publicado en 2010

Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial

artículo científico publicado en 2010

Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND ⬇️

artículo científico publicado el 13 de mayo de 2013

Effect of thyroid hormone on the distribution and activity of Na, K-ATPase in ventricular myocardium

artículo científico publicado en 2008

Effect of thyroid hormone on uncoupling protein-3 mRNA expression in rat heart and skeletal muscle

artículo científico publicado en 2004

Effects of combination lipid therapy in type 2 diabetes mellitus

artículo científico publicado en 2010

Effects of intensive blood-pressure control in type 2 diabetes mellitus

artículo científico publicado en 2010

Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial

artículo científico publicado en 2014

Efficacy of high-fiber diets in the management of type 2 diabetes mellitus

artículo científico publicado en 2011

Endothelin-1 Increases Collagen Accumulation in Renal Mesangial Cells by Stimulating a Chemokine and Cytokine Autocrine Signaling Loop ⬇️

artículo científico publicado el 17 de diciembre de 2010

Exposure to azide markedly decreases the abundance of mRNAs encoding cholesterol synthetic enzymes and inhibits cholesterol synthesis

artículo científico

Factors Leading to High Morbidity and Mortality of COVID-19 in Patients with Type 2 Diabetes

artículo científico publicado en 2020

Glucocorticoid-Induced Fatty Liver Disease

scientific article published on 16 April 2020

Glucose uptake and lactate production in cells exposed to CoCl(2) and in cells overexpressing the Glut-1 glucose transporter

artículo científico publicado en 2002

Glycemia management and cardiovascular risk in type 2 diabetes: an evolving perspective

artículo científico publicado en 2008

Glycemia treatment strategies in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial

artículo científico publicado en 2007

Glycemia-lowering effect of cobalt chloride in the diabetic rat: role of decreased gluconeogenesis ⬇️

artículo científico publicado el 1 de junio de 1998

Human radiation dosimetry of 6-[18F]FDG predicted from preclinical studies

artículo científico publicado en 2014

Hyperglycemia-induced stimulation of glucose transport in skeletal muscle measured by PET-[18F]6FDG and [18F]2FDG.

artículo científico publicado en 2012

Hypoglycemia: Minimizing Its Impact in Type 2 Diabetes ⬇️

artículo científico publicado el 1 de mayo de 2013

Impact of quality mentorship on achievements of Shiraz Medical School in the 1970s and the role of Professors Khosrow Nasr and Asghar Rastegar

artículo científico publicado el 1 de abril de 2013

Impaired fasting glucose and major adverse cardiovascular events by hypertension and dyslipidemia status: the Golestan cohort study

artículo científico publicado en 2020

Individualizing Glycemic Targets in Type 2 Diabetes Mellitus: Implications of Recent Clinical Trials ⬇️

artículo científico publicado el 19 de abril de 2011

Insulin Dose and Cardiovascular Mortality in the ACCORD Trial

artículo científico publicado en 2015

Insulin Fibrillation and Protein Design: Topological Resistance of Single-Chain Analogs to Thermal Degradation with Application to a Pump Reservoir ⬇️

artículo científico publicado el 1 de marzo de 2012

Intermittent Fasting and "Metabolic Switch": Effects on Metabolic Syndrome, Pre-diabetes and Type 2 Diabetes Mellitus

scientific article published on 06 May 2020

Long-Term Effects of Intensive Glucose Lowering on Cardiovascular Outcomes ⬇️

artículo científico publicado el 3 de marzo de 2011

Long-Term Effects of Intensive Glycemic and Blood Pressure Control and Fenofibrate Use on Kidney Outcomes

artículo científico publicado en 2018

Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult

artículo científico publicado en 2006

Near-Normalization of Glucose and Microvascular Diabetes Complications: Data from ACCORD and ADVANCE.

artículo científico publicado en 2011

PPAR-γ agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression

artículo científico publicado en 2014

PS2-27: Near-Normalization of Glucose and Microvascular Diabetes Complications: Data from ACCORD and ADVANCE.

artículo científico publicado en 2011

Paradoxical reduction in HDL-C with fenofibrate and thiazolidinedione therapy in type 2 diabetes: the ACCORD Lipid Trial.

artículo científico publicado en 2013

Pathogenesis and glycemic management of type 2 diabetes mellitus: a physiological approach

artículo científico publicado el 1 de abril de 2012

Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease

artículo científico publicado en 2016

Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial

artículo científico publicado en 2012

Predictive and explanatory factors of cardiovascular disease in people with adequately controlled type 2 diabetes

artículo científico publicado en 2017

Preservation of Beta-Cell Function in Type 2 Diabetes ⬇️

artículo científico publicado el 1 de noviembre de 2010

Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis.

artículo científico publicado en 2018

Protective hinge in insulin opens to enable its receptor engagement

artículo científico publicado en 2014

Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges

artículo científico publicado en 2020

Recommendations for management of diabetes during Ramadan

artículo científico publicado en 2005

Reduction of Insulin Resistance and Plasma Glucose Level by Salsalate Treatment in Persons With Prediabetes ⬇️

artículo científico publicado el 1 de noviembre de 2012

Relationships between cerebral structure and cognitive function in African Americans with type 2 diabetes

scientific article published on 29 May 2018

Response to Comment on Inzucchi et al. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care 2016;39:1684-1692.

artículo científico publicado en 2017

Risk of insulin accumulation (stacking) with use of novel ultralong-acting insulin formulations

artículo científico publicado en 2014

Role of 5'-AMP-activated protein kinase in stimulation of glucose transport in response to inhibition of oxidative phosphorylation

artículo científico publicado en 2005

Role of intensive glucose control in development of renal end points in type 2 diabetes mellitus: systematic review and meta-analysis intensive glucose control in type 2 diabetes

artículo científico publicado en 2012

SGLT-2 inhibitors as promising therapeutics for non-alcoholic fatty liver disease: pathophysiology, clinical outcomes, and future directions

scientific article published on 03 July 2019

Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes.

artículo científico publicado en 2011

Severe hypoglycemia symptoms, antecedent behaviors, immediate consequences and association with glycemia medication usage: Secondary analysis of the ACCORD clinical trial data ⬇️

artículo científico publicado el 30 de mayo de 2012

Shifting Paradigms in the Medical Management of Type 2 Diabetes: Reflections on Recent Cardiovascular Outcome Trials

artículo científico publicado en 2017

Smoking and Diabetes Control in Adults With Type 1 and Type 2 Diabetes: A Nationwide Study From the 2018 National Program for Prevention and Control of Diabetes of Iran

scientific article published on 12 July 2019

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

artículo científico publicado en 2017

Stimulation of Glucose Transport by Hypoxia: Signals and Mechanisms

artículo científico publicado en 1999

Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways

artículo científico publicado en 2008

Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions

artículo científico publicado en 2018

Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

artículo científico publicado en 2010

The Relationship Between the Score on a Simple Measure of Cognitive Function and Incident CVD in People With Diabetes: A Post Hoc Epidemiological Analysis From the ACCORD-MIND Study

artículo científico publicado en 2017

The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study

artículo científico publicado en 2010

The degree of retinopathy is equally predictive for renal and macrovascular outcomes in the ACCORD Trial

artículo científico publicado en 2014

The effects of medical management on the progression of diabetic retinopathy in persons with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Eye Study

artículo científico publicado en 2014

The renal transcriptome of db/db mice identifies putative urinary biomarker proteins in patients with type 2 diabetes: a pilot study ⬇️

artículo científico publicado el 28 de diciembre de 2011

Thyroid hormone regulation of cardiac bioenergetics: role of intracellular creatine

artículo científico publicado en 2002

Triglyceride High-Density Lipoprotein Ratios Predict Glycemia-Lowering in Response to Insulin Sensitizing Drugs in Type 2 Diabetes: A Post Hoc Analysis of the BARI 2D.

artículo científico publicado en 2015

Uptake of 18F-labeled 6-fluoro-6-deoxy-D-glucose by skeletal muscle is responsive to insulin stimulation

artículo científico publicado en 2009

Use of insulin sensitizers for the treatment of major depressive disorder: A pilot study of pioglitazone for major depression accompanied by abdominal obesity ⬇️

artículo científico publicado el 22 de julio de 2011

Using 2H2O to study the influence of feeding on protein synthesis: effect of isotope equilibration in vivo vs. in cell culture.

artículo científico publicado en 2005

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

artículo científico publicado en 2012

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