Lista de obras -

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

artículo científico publicado en 2014

AP-1 binding transcriptionally regulates human neutral ceramidase

artículo científico publicado en 2011

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

artículo científico publicado en 2016

Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

artículo científico publicado en 2020

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

artículo científico publicado en 2012

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

scientific journal article

Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization

artículo científico publicado en 2020

Development of a sphingosine kinase 1 specific small-molecule inhibitor

artículo científico publicado en 2010

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

artículo científico publicado en 2011

Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery

artículo científico publicado en 2008

Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

artículo científico publicado en 2009

Gβ2 and Gβ4 participate in the opioid and adrenergic receptor‐mediated Ca2+ channel modulation in rat sympathetic neurons ⬇️

artículo científico publicado el 18 de junio de 2012

Inflammatory mediators are perpetuated in macrophages resistant to apoptosis induced by hypoxia ⬇️

artículo científico publicado el 9 de diciembre de 1997

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

artículo científico publicado en 2011

Network model of survival signaling in large granular lymphocyte leukemia

artículo científico publicado en 2008

Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation

artículo científico publicado en 2002

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

artículo científico publicado en 2017

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

artículo científico publicado en 2010

Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism

artículo científico publicado en 2007

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

artículo científico publicado en 2016

Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells

scientific article published on 03 April 2007

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

artículo científico publicado en 2009

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

artículo científico publicado en 2008

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

artículo científico publicado en 2015

Sphingosine kinase: a key to solving the 'French Paradox'?

artículo científico publicado en 2012

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

artículo científico publicado en 2010

Targeting sphingosine kinase-1 to inhibit melanoma.

artículo científico publicado en 2012

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

artículo científico publicado en 2015

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

artículo científico

Transcriptional regulation of the human neutral ceramidase gene

artículo científico publicado en 2011

Lista de obras de

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

AP-1 binding transcriptionally regulates human neutral ceramidase

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization

Development of a sphingosine kinase 1 specific small-molecule inhibitor

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery

Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

Gβ2 and Gβ4 participate in the opioid and adrenergic receptor‐mediated Ca2+ channel modulation in rat sympathetic neurons ⬇️

Inflammatory mediators are perpetuated in macrophages resistant to apoptosis induced by hypoxia ⬇️

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

Network model of survival signaling in large granular lymphocyte leukemia

Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Sphingosine kinase: a key to solving the 'French Paradox'?

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

Targeting sphingosine kinase-1 to inhibit melanoma.

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Transcriptional regulation of the human neutral ceramidase gene