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A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

artículo científico publicado en 2014

Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

artículo científico publicado en 2020

Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway

artículo científico publicado en 2002

Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization

artículo científico publicado en 2020

Development of a sphingosine kinase 1 specific small-molecule inhibitor

artículo científico publicado en 2010

Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus

artículo científico publicado en 2009

Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.

artículo científico publicado en 2014

PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate

scientific article published on 14 February 2013

Probing the active sites and mechanisms of rat metalloproteases meprin A and B

scientific journal article

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

artículo científico publicado en 2017

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

artículo científico publicado en 2010

Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism

artículo científico publicado en 2007

Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells

scientific article published on 03 April 2007

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

artículo científico publicado en 2009

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

artículo científico publicado en 2008

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

artículo científico publicado en 2015

Sphingosine kinase: a key to solving the 'French Paradox'?

artículo científico publicado en 2012

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

artículo científico publicado en 2010

Targeting sphingosine kinase-1 to inhibit melanoma.

artículo científico publicado en 2012

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

artículo científico publicado en 2015

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

artículo científico

Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization

artículo científico publicado en 2004

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