Lista de obras -

11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide

artículo científico publicado en 2003

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation

artículo científico publicado en 2012

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

artículo científico publicado en 2010

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase

scientific article published on 27 December 2007

Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs

artículo científico publicado en 2010

Bid maintains mitochondrial cristae structure and protects against cardiac disease in an integrative genomics study

artículo científico publicado en 2018

Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain

artículo científico publicado en 2016

Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine

artículo científico publicado en 2004

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin

artículo científico publicado en 2009

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis

artículo científico publicado en 2010

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice

artículo científico publicado en 2016

Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro

artículo científico publicado en 2002

Cyclooxygenase-dependent lipid-modification of brain proteins

artículo científico publicado en 2005

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

artículo científico publicado en 2002

Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography–tandem mass spectrometry: Application to in vivo pharmacokinetics studies ⬇️

artículo científico publicado el 21 de marzo de 2011

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

artículo científico publicado en 2010

Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function

artículo científico publicado en 2002

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

Functional characterization of mutations in inherited human cPLA₂ deficiency

scientific journal article

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus

scientific article published on 08 November 2018

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator

artículo científico publicado en 2008

Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension

artículo científico publicado en 2020

Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione

artículo científico publicado en 2002

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate

scientific article published on 22 September 2018

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

artículo científico publicado en 2008

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

artículo científico publicado en 2003

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

artículo científico publicado en 2003

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

artículo científico publicado en 2016

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions

scientific article published on 16 October 2019

Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

artículo científico publicado en 2014

Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation

artículo científico publicado en 2003

Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry

artículo científico publicado en 2007

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure ⬇️

artículo científico publicado el 27 de octubre de 2010

Meet Our Editorial Board Member

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers

artículo científico publicado en 2015

Modification of proteins by isoketal-containing oxidized phospholipids

artículo científico publicado en 2004

New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

artículo científico publicado en 2006

On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry

artículo científico publicado en 2011

PGE2 decreases reactivity of human platelets by activating EP2 and EP4

artículo científico publicado en 2010

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42

artículo científico publicado en 2006

Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth

artículo científico publicado en 2010

Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity

artículo científico publicado en 2005

Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers

artículo científico publicado en 2002

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis

artículo científico publicado en 2010

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation

artículo científico publicado en 2011

Protein modification by adenine propenal

artículo científico publicado en 2014

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

artículo científico publicado en 2009

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

artículo científico publicado en 2006

Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues

artículo científico publicado en 2013

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells

artículo científico publicado en 2014

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation

scientific article published in 2018

Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

artículo científico publicado en 2020

Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes

artículo científico publicado en 2010

Suboptimal Inhibition of Platelet Cyclooxygenase-1 by Aspirin in Metabolic Syndrome ⬇️

artículo científico publicado el 6 de febrero de 2012

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

artículo científico publicado en 2014

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension

scientific article published on 04 January 2019

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

artículo científico publicado en 2018

Tristetrapolin Binds to the COX-2 mRNA 3’ Untranslated Region in Cancer Cells ⬇️

artículo científico publicado el 1 de enero de 2003

Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site

artículo científico publicado en 2003

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease

artículo científico publicado en 2015

Lista de obras de

11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase

Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs

Bid maintains mitochondrial cristae structure and protects against cardiac disease in an integrative genomics study

Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain

Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice

Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro

Cyclooxygenase-dependent lipid-modification of brain proteins

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography–tandem mass spectrometry: Application to in vivo pharmacokinetics studies ⬇️

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

Functional characterization of mutations in inherited human cPLA₂ deficiency

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator

Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension

Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions

Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation

Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure ⬇️

Meet Our Editorial Board Member

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers

Modification of proteins by isoketal-containing oxidized phospholipids

New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry

PGE2 decreases reactivity of human platelets by activating EP2 and EP4

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42

Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth

Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity

Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation

Protein modification by adenine propenal

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation

Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes

Suboptimal Inhibition of Platelet Cyclooxygenase-1 by Aspirin in Metabolic Syndrome ⬇️

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

Tristetrapolin Binds to the COX-2 mRNA 3’ Untranslated Region in Cancer Cells ⬇️

Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease