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Lista de obras de Wojciech Rode

A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.

artículo científico publicado en 2008

Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification

artículo científico publicado en 2006

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

artículo científico publicado en 2020

Antitumor and anti-nematode activities of α-mangostin

artículo científico publicado en 2019

Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme

artículo científico publicado en 2005

Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase

artículo científico publicado en 2012

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

artículo científico publicado en 2014

Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer

artículo científico publicado en 2014

Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.

artículo científico

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.

artículo científico publicado en 2009

EGFP fluorescence as an indicator of cancer cells response to methotrexate.

artículo científico publicado en 2006

Electron capture dissociation mass spectrometric analysis of lysine-phosphorylated peptides.

artículo científico publicado en 2010

Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells

artículo científico publicado en 2011

Gold nanoparticle-enhanced target (AuNPET) as universal solution for laser desorption/ionization mass spectrometry analysis and imaging of low molecular weight compounds

artículo científico publicado en 2015

Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.

artículo científico publicado en 2016

Immunofluorescent localization of thymidylate synthase in the development of Trichinella spiralis and Caenorhabditis elegans.

artículo científico publicado en 2012

Increased thymidine kinase activity in human thyroid toxic adenomas: effects of exposure to epidermal growth factor in vitro.

artículo científico publicado en 2004

Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase

scientific article published on 27 July 2007

Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

artículo científico publicado en 2010

Methotrexate-induced senescence in human adenocarcinoma cells is accompanied by induction of p21(waf1/cip1) expression and lack of polyploidy.

artículo científico publicado en 2009

Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations

scientific article published on 01 April 2019

Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme

N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2'-deoxycytidine as a potential boron delivery agent with respect to glioblastoma.

artículo científico publicado en 2017

Novel monoisotopic 109AgNPET for laser desorption/ionization mass spectrometry.

artículo científico publicado en 2013

Nurse cell of Trichinella spp. as a model of long-term cell cycle arrest

artículo científico publicado en 2008

Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells

artículo científico publicado en 2017

Phosphorylation of basic amino acid residues in proteins: important but easily missed

artículo científico publicado el 27 de mayo de 2011

Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N(4)-hydroxy-dCMP.

artículo científico publicado en 2016

Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

artículo científico publicado en 2010

Properties of phosphorylated thymidylate synthase

scientific journal article

Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP.

artículo científico publicado en 2003

Segmental motions of rat thymidylate synthase leading to half-the-sites behaviour

artículo científico publicado en 2010

Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging

artículo científico publicado en 2015

Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.

artículo científico publicado en 2002

Synthesis and NMR properties of derivatives of 5,6-dihydroborauracil and 5,6-dihydroborathymine.

artículo científico publicado en 2009

Synthesis and NMR properties of novel 5,6-dihydroborauracil derivatives.

artículo científico publicado en 2009

Synthesis and NMR properties of the first boron analogues of uracil

artículo científico publicado en 2009

Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid

artículo científico publicado en 2002

Synthesis, reactivity and biological activity of N(4)-boronated derivatives of 2'-deoxycytidine.

artículo científico publicado en 2014

The aromaticity of 5,6-dihydroborauracil, borauracil and benzoborauracil systems.

artículo científico publicado en 2010

The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR

scientific article published on 19 January 2007

The effect of Arg209 to Lys mutation in mouse thymidylate synthase

artículo científico publicado en 2002

The synthesis and NMR investigation on novel boron derivatives of stavudine

artículo científico publicado en 2010

Thiophosphorylation of free amino acids and enzyme protein by thiophosphoramidate ions

artículo científico publicado en 2009

Thymidylate synthase-catalyzed reaction mechanism

artículo científico publicado en 2015

Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP

scientific article published on 11 September 2019

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence.

artículo científico publicado en 2014

Tyrosine nitration affects thymidylate synthase properties.

artículo científico publicado en 2011

Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp.

artículo científico publicado en 2016