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Lista de obras de

2012 Global Summit on Regulatory Science (GSRS-2012)--modernizing toxicology

artículo científico publicado en 2012

A Model to predict severity of drug-induced liver injury in humans

artículo científico publicado en 2016

A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals

artículo científico publicado en 2016

A decade of toxicogenomic research and its contribution to toxicological science

artículo científico

A novel procedure on next generation sequencing data analysis using text mining algorithm

artículo científico publicado en 2016

A phenome-guided drug repositioning through a latent variable model

artículo científico publicado en 2014

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

artículo científico publicado en 2014

A strategy capitalizing on synergies: the Reporting Structure for Biological Investigation (RSBI) working group

artículo científico publicado en 2006

A systems approach for analysis of high content screening assay data with topic modeling

artículo científico publicado en 2013

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

artículo científico publicado en 2014

A unifying ontology to integrate histological and clinical observations for drug-induced liver injury

artículo científico

Alignment of Short Reads: A Crucial Step for Application of Next-Generation Sequencing Data in Precision Medicine

artículo científico publicado en 2015

An FDA bioinformatics tool for microbial genomics research on molecular characterization of bacterial foodborne pathogens using microarrays ⬇️

artículo científico publicado el 7 de octubre de 2010

An approach to comparative analysis of chromatographic fingerprints for assuring the quality of botanical drugs

artículo científico publicado en 2003

An integrated bioinformatics infrastructure essential for advancing pharmacogenomics and personalized medicine in the context of the FDA's Critical Path Initiative

artículo científico

An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms

artículo científico publicado en 2006

An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era

artículo científico publicado en 2014

Application of dynamic topic models to toxicogenomics data

artículo científico publicado en 2016

Application of genome analysis strategies in the clinical testing for pediatric diseases

Applying network analysis and Nebula (neighbor-edges based and unbiased leverage algorithm) to ToxCast data

artículo científico publicado en 2016

ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research

artículo científico publicado en 2003

ArrayTrack: An FDA and Public Genomic Tool

artículo científico

ArrayTrack: a free FDA bioinformatics tool to support emerging biomedical research -- an update ⬇️

artículo científico publicado el 1 de agosto de 2010

ArrayTrack: an FDA and public genomic tool

artículo científico publicado en 2009

Assessing QSAR Limitations - A Regulatory Perspective

Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples

artículo científico publicado en 2008

Assessing consistency between versions of genotype-calling algorithm Birdseed for the Genome-Wide Human SNP Array 6.0 using HapMap samples

artículo científico publicado en 2010

Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures

artículo científico publicado en 2014

Assessment of prediction confidence and domain extrapolation of two structure-activity relationship models for predicting estrogen receptor binding activity

artículo científico publicado en 2004

Asymmetric author-topic model for knowledge discovering of big data in toxicogenomics

artículo científico publicado en 2015

Biomarkers for drug-induced liver injury

artículo científico publicado en 2010

Building an organ-specific carcinogenic database for SAR analyses

artículo científico publicado en 2004

Cancer genomics predicts disease relapse and therapeutic response to neoadjuvant chemotherapy of hormone sensitive breast cancers

artículo científico publicado en 2020

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: a trimethyltin study

artículo científico publicado en 2017

Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data

artículo científico publicado en 2005

Chemometric analysis for identification of botanical raw materials for pharmaceutical use: a case study using Panax notoginseng

artículo científico publicado en 2014

Classification of cDNA array genes that have a highly significant discriminative power due to their unique distribution in four brain regions

scientific article published on 01 October 2004

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

scientific article published on 07 February 2020

Comparative Analysis of Predictive Models for Nongenotoxic Hepatocarcinogenicity Using Both Toxicogenomics and Quantitative Structure–Activity Relationships ⬇️

artículo científico publicado el 20 de junio de 2011

Comparing genetic variants detected in the 1000 genomes project with SNPs determined by the International HapMap Consortium

artículo científico publicado en 2015

Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys

artículo científico publicado en 2011

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

artículo científico publicado en 2015

Competitive molecular docking approach for predicting estrogen receptor subtype α agonists and antagonists

artículo científico publicado en 2014

Comprehensive Assessments of RNA-seq by the SEQC Consortium: FDA-Led Efforts Advance Precision Medicine

artículo científico publicado en 2016

Comprehensive RNA-Seq transcriptomic profiling across 11 organs, 4 ages, and 2 sexes of Fischer 344 rats

artículo científico publicado en 2014

Comprehensively identifying and characterizing the missing gene sequences in human reference genome with integrated analytic approaches

artículo científico publicado en 2013

Computational drug repositioning for rare diseases in the era of precision medicine

artículo científico publicado en 2017

Computational prediction models for assessing endocrine disrupting potential of chemicals

artículo científico publicado en 2018

Constructing a robust protein-protein interaction network by integrating multiple public databases ⬇️

artículo científico publicado el 18 de octubre de 2011

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

artículo científico publicado en 2020

Correction to: Similarities and differences between variants called with human reference genome HG19 or HG38

scholarly article published in BMC Bioinformatics

Correlation analysis of external RNA controls reveals its utility for assessment of microarray assay

artículo científico publicado en 2008

Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine

artículo científico publicado en 2013

Cross-Platform Comparison of Microarray-Based Multiple-Class Prediction ⬇️

artículo científico publicado el 11 de enero de 2011

Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

artículo científico publicado en 2005

Cross-platform ultradeep transcriptomic profiling of human reference RNA samples by RNA-Seq

artículo científico publicado en 2014

Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52

artículo científico publicado en 2005

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

artículo científico publicado en 2016

DNA microarrays are predictive of cancer prognosis: a re-evaluation

scientific article published on 12 January 2010

Decision forest analysis of 61 single nucleotide polymorphisms in a case-control study of esophageal cancer; a novel method

artículo científico publicado en 2005

Decision forest: combining the predictions of multiple independent decision tree models

artículo científico publicado en 2003

Development and Validation of Decision Forest Model for Estrogen Receptor Binding Prediction of Chemicals Using Large Data Sets

artículo científico publicado en 2015

Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.

artículo científico publicado en 2017

Development of public toxicogenomics software for microarray data management and analysis

artículo científico publicado en 2004

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

artículo científico publicado en 2006

Direct comparison of performance of single nucleotide variant calling in human genome with alignment-based and assembly-based approaches

artículo científico publicado en 2017

Discovering functional modules by topic modeling RNA-Seq based toxicogenomic data

artículo científico publicado en 2014

Discovery of Transcriptional Targets Regulated by Nuclear Receptors Using a Probabilistic Graphical Model

artículo científico publicado en 2015

Dissecting the Characteristics and Dynamics of Human Protein Complexes at Transcriptome Cascade Using RNA-Seq Data

artículo científico publicado en 2013

Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity

scientific article published on 01 November 2019

Drug-induced rhabdomyolysis: from systems pharmacology analysis to biochemical flux.

artículo científico publicado en 2014

EADB: an estrogenic activity database for assessing potential endocrine activity.

artículo científico publicado en 2013

Editorial: Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects With Genomic Sciences

scholarly article by Pierre R Bushel & Weida Tong published 2018 in Frontiers in Genetics

Emerging efforts for discovering new biomarkers of liver disease and hepatotoxicity

artículo científico publicado en 2014

Emerging technologies for food and drug safety

artículo científico publicado en 2018

Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus

artículo científico publicado en 2017

Erratum to: A novel procedure on next generation sequencing data analysis using text mining algorithm

artículo científico publicado en 2016

Estimating relative noise to signal in DNA microarray data

artículo científico publicado en 2013

Estrogenic activity data extraction and in silico prediction show the endocrine disruption potential of bisphenol A replacement compounds

artículo científico publicado en 2015

Evaluating variations of genotype calling: a potential source of spurious associations in genome-wide association studies

artículo científico publicado en 2010

Evaluation of Bioinformatics Approaches for Next-Generation Sequencing Analysis of microRNAs with a Toxicogenomics Study Design

artículo científico publicado en 2018

Evaluation of external RNA controls for the assessment of microarray performance

artículo científico publicado en 2006

Evaluation of gene expression data generated from expired Affymetrix GeneChip® microarrays using MAQC reference RNA samples

artículo científico publicado en 2010

Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles

artículo científico publicado en 2015

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

artículo científico publicado en 2008

Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A.

artículo científico publicado en 2016

FAIRsharing, a cohesive community approach to the growth in standards, repositories and policies

FDA drug labeling: rich resources to facilitate precision medicine, drug safety, and regulatory science

artículo científico publicado en 2016

FDA-approved drug labeling for the study of drug-induced liver injury

article

Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost

artículo científico publicado en 2019

GOFFA: gene ontology for functional analysis--a FDA gene ontology tool for analysis of genomic and proteomic data

artículo científico publicado en 2006

Gaining Confidence on Molecular Classification through Consensus Modeling and Validation

artículo científico publicado en 2006

Gene expression profile exploration of a large dataset on chronic fatigue syndrome

artículo científico publicado en 2006

Global Summit on Regulatory Science 2013.

artículo científico publicado en 2014

High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury

artículo científico publicado en 2014

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

artículo científico publicado en 2013

Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human <i>α</i>4<i>β</i>2 Nicotinic Acetylcholine Receptor

Homology modeling, molecular docking, and molecular dynamics simulations elucidated α-fetoprotein binding modes

artículo científico publicado en 2013

Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein

artículo científico publicado en 2014

ISA software suite: supporting standards-compliant experimental annotation and enabling curation at the community level

artículo científico publicado en 2010

In silico drug repositioning: what we need to know

artículo científico publicado en 2012

In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method

artículo científico publicado en 2017

Incorporating the human gene annotations in different databases significantly improved transcriptomic and genetic analyses

artículo científico publicado en 2013

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

artículo científico publicado en 2016

Integrating adverse outcome pathways (AOPs) and high throughput in vitro assays for better risk evaluations, a study with drug-induced liver injury (DILI)

scientific article published on 08 November 2019

Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium

artículo científico publicado en 2005

Investigating drug repositioning opportunities in FDA drug labels through topic modeling

artículo científico publicado en 2012

Investigation of reproducibility of differentially expressed genes in DNA microarrays through statistical simulation

artículo científico publicado en 2009

Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?

artículo científico publicado en 2011

Lessons Learned from Two Decades of Anticancer Drugs

artículo científico publicado en 2017

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

artículo científico publicado en 2020

Machine Learning Methods for Predicting HLA-Peptide Binding Activity

artículo científico publicado en 2015

Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats

artículo científico publicado en 2017

Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades

artículo científico publicado en 2016

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

artículo científico publicado en 2006

Meta-analysis of microarray data using a pathway-based approach identifies a 37-gene expression signature for systemic lupus erythematosus in human peripheral blood mononuclear cells ⬇️

artículo científico publicado el 30 de mayo de 2011

Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells

artículo científico publicado en 2006

Microarray scanner calibration curves: characteristics and implications

artículo científico publicado en 2005

Mining FDA drug labels using an unsupervised learning technique - topic modeling ⬇️

artículo científico publicado el 18 de octubre de 2011

Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study

artículo científico publicado en 2014

Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes ⬇️

artículo científico publicado el 15 de marzo de 2012

Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme ⬇️

artículo científico publicado el 15 de marzo de 2012

Mold(2), molecular descriptors from 2D structures for chemoinformatics and toxicoinformatics

artículo científico publicado en 2008

Molecular biomarkers: a US FDA effort

artículo científico publicado en 2010

Molecular docking to identify associations between drugs and class I human leukocyte antigens for predicting idiosyncratic drug reactions.

artículo científico publicado en 2015

Molecular regulation of miRNAs and potential biomarkers in the progression of hepatic steatosis to NASH

artículo científico publicado en 2015

Multi-class cancer classification by total principal component regression (TPCR) using microarray gene expression data

artículo científico publicado en 2005

Multi-class tumor classification by discriminant partial least squares using microarray gene expression data and assessment of classification models

artículo científico publicado en 2004

Multiclass Decision Forest--a novel pattern recognition method for multiclass classification in microarray data analysis

artículo científico publicado en 2004

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

artículo científico publicado en 2017

NETBAGs: a network-based clustering approach with gene signatures for cancer subtyping analysis

artículo científico publicado en 2015

Next generation sequencing for profiling expression of miRNAs: technical progress and applications in drug development ⬇️

artículo científico publicado el 1 de octubre de 2011

Next-generation sequencing and its applications in molecular diagnostics

artículo científico publicado en 2011

Of text and gene--using text mining methods to uncover hidden knowledge in toxicogenomics

artículo científico publicado en 2014

Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors

artículo científico publicado en 2016

Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project

artículo científico publicado en 2006

Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods

artículo científico publicado en 2019

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

artículo científico publicado en 2013

Phytoestrogens and mycoestrogens bind to the rat uterine estrogen receptor

scientific article published on 01 April 2002

Potential Reuse of Oncology Drugs in the Treatment of Rare Diseases

artículo científico publicado en 2016

Predicting idiosyncratic drug-induced liver injury: some recent advances

artículo científico publicado en 2014

Prediction of estrogen receptor binding for 58,000 chemicals using an integrated system of a tree-based model with structural alerts

artículo científico publicado en 2002

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

artículo científico publicado en 2014

QA/QC issues to aid regulatory acceptance of microarray gene expression data

artículo científico publicado en 2007

QA/QC: challenges and pitfalls facing the microarray community and regulatory agencies

artículo científico publicado en 2004

QSAR Models at the US FDA/NCTR.

artículo científico publicado en 2016

QuaPra: Efficient transcript assembly and quantification using quadratic programming with Apriori algorithm

artículo científico publicado en 2019

Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS).

artículo científico publicado en 2005

Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology

artículo científico publicado en 2003

Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs

artículo científico publicado en 2013

Rat toxicogenomic study reveals analytical consistency across microarray platforms

artículo científico publicado en 2006

Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities

artículo científico publicado en 2012

Regulatory bioinformatics for food and drug safety

artículo científico publicado en 2016

Regulatory landscape of dietary supplements and herbal medicines from a global perspective

scientific article published on 16 April 2020

Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential

artículo científico publicado en 2007

SNPTrack™ : an integrated bioinformatics system for genetic association studies

artículo científico publicado en 2012

Selecting a single model or combining multiple models for microarray-based classifier development? – A comparative analysis based on large and diverse datasets generated from the MAQC-II project ⬇️

artículo científico publicado el 18 de octubre de 2011

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays

scientific article published on 01 January 2007

Sequencing XMET genes to promote genotype-guided risk assessment and precision medicine

artículo científico publicado en 2019

Significant variations in alternative splicing patterns and expression profiles between human-mouse orthologs in early embryos

artículo científico publicado en 2016

Similarities and differences between variants called with human reference genome HG19 or HG38

Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations.

artículo científico publicado en 2018

Structure-activity relationship approaches and applications

artículo científico publicado en 2003

Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery

artículo científico publicado en 2016

Study of 202 Natural, Synthetic, and Environmental Chemicals for Binding to the Androgen Receptor ⬇️

artículo científico publicado el 1 de octubre de 2003

Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine

artículo científico publicado en 2020

Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA

Technical reproducibility of genotyping SNP arrays used in genome-wide association studies

artículo científico publicado en 2012

The EDKB: an established knowledge base for endocrine disrupting chemicals

artículo científico publicado en 2010

The FDA's Experience with Emerging Genomics Technologies-Past, Present, and Future

artículo científico publicado en 2016

The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury

artículo científico publicado en 2017

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

artículo científico publicado en 2006

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

artículo científico publicado en 2010

The accurate prediction of protein family from amino acid sequence by measuring features of sequence fragments

artículo científico publicado en 2009

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

artículo científico publicado en 2008

The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance

artículo científico publicado en 2014

The first RSBI (ISA-TAB) workshop: "can a simple format work for complex studies?".

artículo científico publicado en 2008

The international MAQC Society launches to enhance reproducibility of high-throughput technologies

artículo científico publicado en 2017

Toward Clinical Implementation of Next-Generation Sequencing-Based Genetic Testing in Rare Diseases: Where Are We?

scientific article published on 14 October 2019

Toward a checklist for exchange and interpretation of data from a toxicology study

artículo científico publicado en 2007

Toward interoperable bioscience data

artículo científico publicado en 2012

Toward predictive models for drug-induced liver injury in humans: are we there yet?

artículo científico

Towards interoperable reporting standards for omics data: hopes and hurdles

artículo científico publicado en 2009

Towards the development of an omics data analysis framework

artículo científico publicado en 2020

Toxicogenomics: A 2020 Vision

scientific article published on 26 December 2018

Transcriptional Responses Reveal Similarities Between Preclinical Rat Liver Testing Systems.

artículo científico publicado en 2018

Transcriptomic profiling of rat liver samples in a comprehensive study design by RNA-Seq

artículo científico publicado en 2014

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps) ⬇️

artículo científico publicado el 15 de diciembre de 2011

Two new ArrayTrack libraries for personalized biomedical research ⬇️

artículo científico publicado el 7 de octubre de 2010

Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis

artículo científico publicado en 2015

Using decision forest to classify prostate cancer samples on the basis of SELDI-TOF MS data: assessing chance correlation and prediction confidence

artículo científico publicado en 2004

Versatility or promiscuity: the estrogen receptors, control of ligand selectivity and an update on subtype selective ligands

artículo científico publicado en 2014

Very Important Pool (VIP) genes--an application for microarray-based molecular signatures

artículo científico publicado en 2008

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

artículo científico publicado en 2010

Whole genome sequencing of 35 individuals provides insights into the genetic architecture of Korean population

artículo científico publicado en 2014

atBioNet--an integrated network analysis tool for genomics and biomarker discovery

artículo científico publicado en 2012

ebTrack: an environmental bioinformatics system built upon ArrayTrack

artículo científico publicado en 2009

miRNAs and their application in drug-induced liver injury

artículo científico

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