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Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

artículo científico publicado en 2016

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

artículo científico

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

artículo científico publicado en 2013

Discovery and development of imaging-capable bacterial nitroreductases and their cytotoxic prodrugs for Clostridium sporogenes based gene therapy ⬇️

2015 doctoral thesis by Alexandra Mowday at University of Auckland

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

artículo científico publicado en 2019

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.

artículo científico publicado en 2017

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

artículo científico publicado en 2022

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

artículo científico publicado en 2011

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

artículo científico

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

artículo científico publicado en 2013

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

artículo científico publicado en 2016

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

artículo científico publicado en 2021

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

artículo científico publicado en 2021

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.

artículo científico publicado en 2012

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

artículo científico publicado en 2021

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide

artículo científico publicado en 2020

Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours

artículo científico publicado en 2021

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