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A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

artículo científico publicado en 2015

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

artículo científico publicado en 2004

A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke

artículo científico publicado en 2017

A deficiency of uPAR alters endothelial angiogenic function and cell morphology ⬇️

artículo científico publicado en 2011

A fast-acting, modular-structured staphylokinase fusion with Kringle-1 from human plasminogen as the fibrin-targeting domain offers improved clot lysis efficacy

artículo científico publicado en 2003

A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

artículo científico publicado en 2006

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

artículo científico publicado en 2013

A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen

scientific article published on 09 April 2020

A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis

artículo científico publicado en 2008

A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes

artículo científico publicado en 2013

A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.

artículo científico publicado en 2004

A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells

artículo científico publicado en 2006

A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model

artículo científico publicado en 2004

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice

artículo científico publicado en 2009

A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide

artículo científico publicado en 2004

A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins

artículo científico publicado en 2008

A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate

artículo científico publicado en 2004

A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans

artículo científico publicado en 2020

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

artículo científico publicado en 2011

ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo

artículo científico publicado en 2009

Abnormal whole blood thrombi in humans with inherited platelet receptor defects

artículo científico publicado en 2012

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia ⬇️

artículo científico publicado en 2015

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

artículo científico publicado en 2003

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

artículo científico publicado en 2010

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

artículo científico publicado en 2009

Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis

artículo científico publicado en 2016

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

artículo científico publicado en 2006

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

artículo científico publicado en 2010

Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling

artículo científico publicado en 2013

Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination

artículo científico publicado en 2012

Binding and orientation of conantokins in PL vesicles and aligned PL multilayers.

artículo científico publicado en 2003

Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography ⬇️

artículo científico publicado el 1 de septiembre de 2011

Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues.

artículo científico publicado en 2010

Cathepsin E is a specific marker of dysplasia in APC mouse intestine.

artículo científico publicado en 2005

Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.

artículo científico publicado en 2018

Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation

artículo científico publicado en 2013

Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase

artículo científico publicado en 2012

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

artículo científico publicado en 2019

Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation

scientific article published on 11 May 2017

Coagulation factor Xa modulates airway remodeling in a murine model of asthma

artículo científico publicado en 2006

Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers

artículo científico publicado en 2017

Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system

artículo científico publicado en 2013

Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke

artículo científico publicado en 2015

Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice

artículo científico publicado en 2006

Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation

artículo científico publicado en 2010

Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.

artículo científico publicado en 2017

Conservation of critical functional domains in murine plasminogen activator inhibitor-1.

artículo científico publicado en 2004

Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization

artículo científico publicado en 2018

CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants

artículo científico publicado en 2015

Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces

artículo científico publicado en 2003

Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis

artículo científico publicado en 2007

Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

artículo científico publicado en 2014

Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein

artículo científico publicado en 2015

Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors.

artículo científico publicado en 2016

Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes.

artículo científico publicado en 2018

Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

artículo científico publicado en 2016

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans

artículo científico publicado en 2013

Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.

artículo científico publicado en 2012

Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.

artículo científico publicado en 2011

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).

artículo científico publicado en 2010

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

artículo científico publicado en 2009

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

artículo científico publicado en 2008

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

artículo científico publicado en 2007

Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice.

artículo científico publicado en 2003

Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

artículo científico publicado en 2007

FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse

artículo científico publicado en 2002

Factor VII deficiency impairs cutaneous wound healing in mice

artículo científico publicado en 2010

Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

artículo científico publicado en 2016

Fas ligand expression and its correlation with apoptosis and proliferation in Lobund-Wistar prostate carcinomas.

artículo científico publicado en 2005

Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.

artículo científico publicado en 2010

Fibrinogen facilitates the anti-tumor effect of nonnative endostatin

artículo científico publicado en 2009

Fibrinogen has chaperone-like activity

artículo científico publicado en 2008

Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse

artículo científico publicado en 2002

Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between".

artículo científico publicado en 2017

Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene

artículo científico publicado en 2006

Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains

artículo científico publicado en 2013

Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence

artículo científico publicado en 2009

Gene targeting of components of the fibrinolytic system

artículo científico publicado en 2002

Generation of genetically-altered mice producing very low levels of coagulation factorVII

artículo científico publicado en 2005

Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

artículo científico publicado en 2016

Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.

artículo científico publicado en 2007

Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine

artículo científico publicado en 2015

Host Pathways of Hemostasis that Regulate Group A Streptococcus pyogenes Pathogenicity

artículo científico publicado en 2020

Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors

artículo científico publicado en 2015

In situ metabolite and lipid analysis of GluN2D-/- and wild-type mice after ischemic stroke using MALDI MSI

scientific article published on 28 February 2020

Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation

artículo científico publicado en 2006

Maternal fibrinogen is necessary for embryonic development

artículo científico publicado en 2005

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.

artículo científico publicado en 2010

Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities

artículo científico publicado en 2005

Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge

artículo científico publicado en 2002

Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen ⬇️

artículo científico publicado el 16 de junio de 2011

Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence

artículo científico publicado en 2014

N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein

artículo científico publicado en 2008

NMR backbone dynamics of VEK-30 bound to the human plasminogen kringle 2 domain

artículo científico publicado en 2010

NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins

artículo científico publicado en 2008

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

scientific article published on 03 July 2018

Non-invasive imaging and analysis of cerebral ischemia in living rats using positron emission tomography with 18F-FDG.

artículo científico publicado en 2014

Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues

artículo científico publicado en 2009

Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence

artículo científico publicado en 2016

Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers

artículo científico publicado en 2004

Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors ⬇️

artículo científico publicado el 27 de enero de 2012

Past and Present Behçet's Disease Animal Models

artículo científico publicado en 2020

Pharmacology of triheteromeric N-Methyl-D-Aspartate Receptors

artículo científico publicado en 2016

Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps

artículo científico publicado en 2016

Plasma levels of bradykinin are suppressed in factor XII-deficient mice

artículo científico publicado en 2006

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

artículo científico publicado en 2017

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

artículo científico publicado en 2009

Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

artículo científico publicado en 2016

Plasminogen enhances neuritogenesis on laminin-1.

artículo científico publicado en 2009

Plasminogen inhibits TNFalpha-induced apoptosis in monocytes

artículo científico publicado en 2006

Plasminogen receptors: the sine qua non of cell surface plasminogen activation

artículo científico publicado en 2005

Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy.

artículo científico publicado en 2013

Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons

artículo científico publicado en 2014

Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.

artículo científico publicado en 2008

Rapid selection of Drosophila S2 cells with the puromycin resistance gene ⬇️

artículo científico publicado el 1 de septiembre de 2003

Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48.

artículo científico publicado en 2018

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

scientific article published on 01 January 2019

Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties

artículo científico publicado en 2005

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes

artículo científico publicado en 2019

Solution structure and functional characterization of human plasminogen kringle 5

artículo científico publicado en 2009

Solution structure of the complex of VEK-30 and plasminogen kringle 2

artículo científico publicado en 2010

Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain

scientific article published on 25 September 2019

Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

artículo científico publicado en 2020

Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria

artículo científico publicado en 2016

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

scientific article published on 08 July 2019

Structure and function of the plasminogen/plasmin system

artículo científico publicado en 2005

Structure-function analysis of the streptokinase amino terminus (residues 1-59).

artículo científico publicado en 2003

Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides

artículo científico

Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice

artículo científico publicado en 2008

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

scientific article published on 21 February 2020

Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells

artículo científico publicado en 2014

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

artículo científico publicado en 2014

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

artículo científico publicado en 2016

The M-protein of Streptococcus pyogenes strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene

artículo científico publicado en 2020

The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen Staphylococcus aureus USA300 through cleavage of the Staphylococcal SdrC protein

artículo científico publicado en 2020

The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin

artículo científico publicado en 2002

The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice

artículo científico publicado en 2004

The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer

artículo científico publicado en 2010

The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif

artículo científico publicado en 2007

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

artículo científico publicado en 2010

The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine

artículo científico publicado en 2012

The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury

artículo científico publicado en 2005

The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection

artículo científico publicado en 2003

The hemostasis system in murine atherosclerosis

artículo científico publicado en 2008

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

artículo científico publicado en 2007

The molecular basis of conantokin antagonism of NMDA receptor function

artículo científico publicado en 2007

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications ⬇️

artículo científico publicado en 2009

The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

artículo científico publicado en 2009

The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors

artículo científico publicado en 2014

Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study.

artículo científico publicado en 2016

Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.

artículo científico publicado en 2003

Tissue distribution of fetal liver cells following in utero transplantation in mice

artículo científico publicado en 2005

Tranexamic Acid for Trauma Resuscitation in the United States of America

artículo científico publicado en 2016

Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse

artículo científico publicado en 2003

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.

artículo científico publicado en 2014

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

artículo científico publicado en 2011

Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence

artículo científico publicado en 2014

Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review

scientific article published on 20 May 2019

Use of phospholipid bilayers and monolayers in binding studies of vitamin K-dependent blood coagulation proteins

artículo científico publicado en 2002

Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion

artículo científico publicado en 2017

Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen

scientific article published on 14 March 2019

X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM.

artículo científico publicado en 2006

alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator

artículo científico publicado en 2004

gamma-Glutamate and beta-hydroxyaspartate in proteins

artículo científico publicado en 2008

gamma-glutamate and beta-hydroxyaspartate in proteins

scientific article published on 01 January 2002

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