Lista de obras -

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

artículo científico publicado en 2008

Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation

artículo científico publicado en 2002

Attenuated liver fibrosis in the absence of B cells

artículo científico publicado en 2005

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

artículo científico publicado en 2002

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

artículo científico publicado en 2017

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

artículo científico publicado en 2014

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

scientific article published in Nature

Development of lipidoid-siRNA formulations for systemic delivery to the liver

artículo científico publicado en 2009

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy

artículo científico publicado en 2002

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

artículo científico

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

artículo científico publicado en 2010

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody.

artículo científico publicado en 2005

Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice

artículo científico publicado en 2005

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

artículo científico publicado en 2014

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

artículo científico publicado en 2008

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

artículo científico publicado en 2012

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

artículo científico publicado en 2017

Identification of siRNA delivery enhancers by a chemical library screen

artículo científico publicado en 2015

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

artículo científico publicado en 2013

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

artículo científico publicado en 2011

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

artículo científico publicado en 2019

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling

artículo científico publicado en 2014

Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration

artículo científico publicado en 2017

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

artículo científico publicado en 2016

Lipid-like materials for low-dose, in vivo gene silencing

artículo científico publicado en 2010

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

artículo científico publicado en 2014

Liquid-crystal organization of liver tissue

artículo científico publicado en 2019

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.

artículo científico publicado en 2014

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter

artículo científico publicado en 2013

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

artículo científico publicado en 2013

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

artículo científico publicado en 2007

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

scientific journal article

Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis

artículo científico publicado en 2003

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.

artículo científico publicado en 2014

Origins of tumor-associated macrophages and neutrophils.

artículo científico publicado en 2012

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

artículo científico publicado en 2018

RNAi therapeutics: a potential new class of pharmaceutical drugs

artículo científico publicado en 2006

RNAi-mediated gene silencing in non-human primates.

artículo científico publicado en 2006

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver

artículo científico publicado en 2015

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

artículo científico publicado en 2012

Regulation of liver metabolism by the endosomal GTPase Rab5.

artículo científico publicado en 2015

Silencing of CCR2 in myocarditis

artículo científico publicado en 2014

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

artículo científico publicado en 2012

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

artículo científico publicado en 2017

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

artículo científico publicado en 2012

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

artículo científico publicado en 2010

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals ⬇️

artículo científico publicado el 8 de febrero de 2012

The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection

artículo científico publicado en 2004

The roles of individual mammalian argonautes in RNA interference in vivo

artículo científico publicado en 2014

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

artículo científico publicado en 2008

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

artículo científico publicado en 2016

Therapeutic siRNA silencing in inflammatory monocytes in mice

artículo científico publicado en 2011

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

artículo científico publicado en 2004

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

artículo científico publicado en 2012

lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference

artículo científico publicado en 2016

Lista de obras de

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation

Attenuated liver fibrosis in the absence of B cells

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Development of lipidoid-siRNA formulations for systemic delivery to the liver

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody.

Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Identification of siRNA delivery enhancers by a chemical library screen

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling

Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

Lipid-like materials for low-dose, in vivo gene silencing

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Liquid-crystal organization of liver tissue

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice.

Origins of tumor-associated macrophages and neutrophils.

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

RNAi therapeutics: a potential new class of pharmaceutical drugs

RNAi-mediated gene silencing in non-human primates.

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

Regulation of liver metabolism by the endosomal GTPase Rab5.

Silencing of CCR2 in myocarditis

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals ⬇️

The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection

The roles of individual mammalian argonautes in RNA interference in vivo

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Therapeutic siRNA silencing in inflammatory monocytes in mice

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference