Lista de obras -

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

artículo científico publicado en 2017

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

artículo científico publicado en 2017

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

artículo científico publicado en 2015

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

artículo científico publicado en 2014

An economic framework to prioritize confirmatory tests after a high-throughput screen.

artículo científico publicado en 2010

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

artículo científico publicado en 2013

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

artículo científico publicado en 2013

Automatically detecting workflows in PubChem.

artículo científico publicado en 2012

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

artículo científico publicado en 2015

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

artículo científico publicado en 2011

Directed evolution of protein enzymes using nonhomologous random recombination

artículo científico publicado en 2004

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

artículo científico publicado en 2020

Discovery of Inhibitors of Anti-Apoptotic Protein A1

artículo científico publicado en 2012

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

artículo científico publicado en 2016

Enhancing the rate of scaffold discovery with diversity-oriented prioritization

artículo científico publicado en 2011

Evolving BioAssay Ontology (BAO): modularization, integration and applications

artículo científico publicado en 2014

Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection

artículo científico publicado en 2005

Genetic and transcriptional evolution alters cancer cell line drug response

artículo científico publicado en 2018

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

artículo científico publicado en 2015

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

artículo científico publicado en 2018

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding.

artículo científico publicado en 2018

High-Throughput RT-PCR for small-molecule screening assays

artículo científico publicado en 2012

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

artículo científico publicado en 2017

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

scholarly article published 4 April 2015

Identification of a small molecule that selectively activates alpha-synuclein translational expression

artículo científico publicado en 2011

Identification of a small molecule that selectively inhibits alpha-synuclein translational expression

artículo científico publicado en 2011

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2

Identification of small-molecule inhibitors of Trypansoma cruzi replication

artículo científico publicado en 2011

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

artículo científico publicado en 2013

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

artículo científico publicado en 2013

Nucleic acid evolution and minimization by nonhomologous random recombination

artículo científico publicado en 2002

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

artículo científico publicado en 2012

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

artículo científico publicado en 2011

Recent advances in the in vitro evolution of nucleic acids

artículo científico publicado en 2002

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1

artículo científico publicado en 2011

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2

artículo científico publicado en 2012

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

artículo científico

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

artículo científico publicado en 2010

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

artículo científico publicado en 2017

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2014

The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity

scientific article published on 01 April 2019

The Drug Repurposing Hub: a next-generation drug library and information resource

artículo científico publicado en 2017

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

artículo científico publicado en 2014

Utility-aware screening with clique-oriented prioritization.

artículo científico publicado en 2011

Lista de obras de

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

An economic framework to prioritize confirmatory tests after a high-throughput screen.

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

Automatically detecting workflows in PubChem.

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Directed evolution of protein enzymes using nonhomologous random recombination

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

Discovery of Inhibitors of Anti-Apoptotic Protein A1

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Enhancing the rate of scaffold discovery with diversity-oriented prioritization

Evolving BioAssay Ontology (BAO): modularization, integration and applications

Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection

Genetic and transcriptional evolution alters cancer cell line drug response

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding.

High-Throughput RT-PCR for small-molecule screening assays

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

Identification of a small molecule that selectively activates alpha-synuclein translational expression

Identification of a small molecule that selectively inhibits alpha-synuclein translational expression

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2

Identification of small-molecule inhibitors of Trypansoma cruzi replication

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

Nucleic acid evolution and minimization by nonhomologous random recombination

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

Recent advances in the in vitro evolution of nucleic acids

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity

The Drug Repurposing Hub: a next-generation drug library and information resource

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

Utility-aware screening with clique-oriented prioritization.