Lista de obras -

A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma

artículo científico publicado en 2020

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis

scholarly article by Ulrike Heinicke published in June 2018

BCL-xL-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis.

artículo científico publicado en 2017

Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells

Identification of Smac mimetics as novel substrates for p-glycoprotein

Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity

artículo científico publicado en 2005

NRAS-mutated rhabdomyosarcoma cells are vulnerable to mitochondrial apoptosis induced by co-inhibition of MEK and PI3Kα.

artículo científico publicado en 2018

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

scientific article published on 12 December 2019

Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis

artículo científico publicado en 2020

Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations

scholarly article by Kristina Henz published in July 2018

Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase

artículo científico publicado en 2005

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML

scientific article published on 04 December 2019

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

scientific article published on 25 November 2008

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma

artículo científico publicado en 2009

Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma

scientific article published on 10 October 2019

Targeting BCL-2 proteins in pediatric cancer: Dual inhibition of BCL-XL and MCL-1 leads to rapid induction of intrinsic apoptosis

scientific article published on 04 March 2020

Targeting BCL2-Proteins for the Treatment of Solid Tumours

artículo científico publicado en 2014

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

artículo científico publicado en 2008

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