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1-Methyl-4-phenylpyridinium (MPP+) does not exhibit paraquat-like immunoreactivity

artículo científico publicado en 1990

A case report of transient but clinically relevant interaction between methadone and duloxetine: a reply to McCance-Katz et al.

artículo científico publicado en 2010

A critical review of antidotal immunotherapy for low molecular weight toxins. Current antidotes and perspectives

artículo científico publicado en 1997

A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters

artículo científico publicado en 2007

A physiologically based modeling strategy during preclinical CNS drug development.

artículo científico publicado en 2014

A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood-retinal barrier.

artículo científico publicado en 2015

ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas

artículo científico publicado en 2019

ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

artículo científico publicado en 2010

ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells.

artículo científico publicado en 2008

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

artículo científico publicado en 2008

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

artículo científico publicado en 2012

Affinity and dose-dependent digoxin Na+K+ATPase dissociation by monoclonal digoxin-specific antibodies

artículo científico publicado en 1995

Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD).

artículo científico publicado en 2016

Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease

artículo científico publicado en 2014

Antibodies proposed as therapeutic agents

artículo científico publicado en 1996

Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells

artículo científico publicado en 2003

Aryl hydrocarbon receptor regulates CYP1B1 but not ABCB1 and ABCG2 in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure

artículo científico publicado en 2015

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels

artículo científico publicado en 2011

Association constants of monoclonal antibodies for hapten: heterogeneity of frequency distribution and possible relationship with hapten molecular weight

artículo científico publicado en 1994

Binding of colchicine and thiocolchicoside to human serum proteins and blood cells.

artículo científico publicado en 1994

Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier

artículo científico publicado en 2015

Brain drug delivery technologies: novel approaches for transporting therapeutics

artículo científico publicado en 2000

Brain microdialysis in the mouse

artículo científico publicado en 1995

Brief report: treatment of severe colchicine overdose with colchicine-specific Fab fragments

scientific article published on 01 March 1995

CNS delivery via adsorptive transcytosis

artículo científico publicado en 2008

Carrier-mediated cocaine transport at the blood-brain barrier as a putative mechanism in addiction liability.

artículo científico publicado en 2014

Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-beta-D-glucuronide

artículo científico publicado en 2005

Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2.

artículo científico publicado en 2008

Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs.

artículo científico publicado en 2009

Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier.

artículo científico publicado en 2012

Colchicine concentration in leukocytes of patients with familial Mediterranean fever

artículo científico publicado en 1994

Colchicine in tear fluid of treated patients with familial Mediterranean fever

artículo científico publicado en 2003

Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization

artículo científico publicado en 2004

Colchicine poisoning apropos of a pediatric case

artículo científico publicado en 1994

Colchicine today

artículo científico publicado en 2006

Colchicine-specific Fab fragments alter colchicine disposition in rabbits ⬇️

artículo científico publicado el 1 de marzo de 1992

Combined ursodeoxycholic acid plus colchicine--treatment of primary biliary cirrhosis: results of a placebo-controlled double-blind study

artículo científico publicado el 1 de marzo de 1992

Comment on: Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial

artículo científico publicado en 2020

Commentary: current advances and future directions for CNS delivery

artículo científico publicado en 2008

Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human

artículo científico publicado en 2014

Comparison of colchicine toxicity on different dysmyelinating mutant models.

artículo científico publicado en 1989

Concepts for toxicokinetic-toxicodynamic modelling in clinical toxicology: application to acute cardiac glycoside intoxications

artículo científico publicado el 1 de enero de 1992

Covalent modifications of antitetanus F(ab')2 fragments with natural and synthetic polyamines and their effects on the antibody endocytosis in cultured HL60 cells

artículo científico publicado en 2008

Design of cocaethylene and cocaine conjugates to produce highly selective polyclonal antibodies

artículo científico publicado en 2006

Determination of 3,4-methylenedioxymethamphetamine and its five main metabolites in rat urine by solid-phase extraction and high performance liquid chromatography with on line mass spectrometry ⬇️

artículo científico publicado el 21 de agosto de 2010

Development and validation of an antigen-binding capture ELISA for native and putrescine-modified anti-tetanus F(ab')2 fragments for the assessment of the cellular uptake and plasma kinetics of the antibodies

artículo científico publicado en 2005

Development of a physiologically based pharmacokinetic model for the rat central nervous system and determination of an in vitro-in vivo scaling methodology for the blood-brain barrier permeability of two transporter substrates, morphine and oxycodo

artículo científico publicado en 2012

Discrepancies in the P-glycoprotein-mediated transport of (18)F-MPPF: a pharmacokinetic study in mice and non-human primates.

artículo científico publicado en 2012

Dose-dependent delivery of colchicine to the rat hippocampus by microdialysis

artículo científico publicado en 1996

Dose-dependent reversal of acute murine colchicine poisoning by goat colchicine-specific Fab fragments

artículo científico publicado en 1991

Dose-dependent reversal of digoxin-inhibited activity of an in vitro Na+K+ATPase model by digoxin-specific antibody

artículo científico publicado en 1996

Doxorubicin-peptide conjugates overcome multidrug resistance

artículo científico publicado en 2001

Effect of Long-term In Vitro Lithium Exposure on mRNA Levels of Claudin-3, CYP1A1, ABCG2 and GSTM3 Genes in the hCMEC/D3 Human Brain Endothelial Cell Line

artículo científico publicado en 2017

Effect of a Roux-en-Y gastric bypass on the pharmacokinetics of oral morphine using a population approach

artículo científico publicado en 2014

Effect of antivenom on venom pharmacokinetics in experimentally envenomed rabbits: toward an optimization of antivenom therapy

scientific article published on 01 April 1997

Effect of chronic exposure to morphine on the rat blood-brain barrier: focus on the P-glycoprotein

artículo científico publicado en 2008

Effect of colchicine-specific Fab fragments on the hepatic clearance of colchicine

scientific article published on 01 November 1993

Effect of social isolation on the metabolism of morphine and its passage through the blood-brain barrier and on consumption of sucrose solutions

artículo científico publicado en 1999

Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.

artículo científico publicado en 2010

Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells

artículo científico publicado en 2008

Effects of selected OATP and/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide

artículo científico publicado en 2013

Efflux of intracellular colchicine in lymphocytes with colchicine-specific Fab fragments

scientific article published on 01 September 1995

Elimination of paraquat

artículo científico publicado en 1987

Elimination of paraquat

artículo científico publicado en 1986

Enhanced cellular uptake and transport of polyclonal immunoglobulin G and fab after their cationization

scientific article published on 01 January 2000

Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier.

artículo científico publicado en 2003

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

artículo científico publicado en 2017

Expression and function of multidrug resistance transporters at the blood-brain barriers

artículo científico publicado en 2005

Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell line

artículo científico publicado en 2012

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

artículo científico publicado en 2008

Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes.

artículo científico publicado en 2004

Expression of drug transporters at the blood-brain barrier using an optimized isolated rat brain microvessel strategy.

artículo científico publicado en 2006

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

artículo científico publicado en 2004

Extrahepatic metabolism of morphine occurs in humans

artículo científico publicado en 1990

Fab-bound colchicine appears to adopt Fab fragment disposition in rats

artículo científico publicado el 1 de diciembre de 1992

Facilitation of imipramine efflux from the brain by systemic specific antibodies

artículo científico publicado en 1996

Heterogeneity in the Rat Brain Vasculature Revealed by Quantitative Confocal Analysis of Endothelial Barrier Antigen and P-Glycoprotein Expression ⬇️

artículo científico publicado el 27 de julio de 2011

How to obtain DNA from injection drug users?

artículo científico publicado en 2011

Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration

artículo científico publicado en 2014

Hurdles with using in vitro models to predict human blood-brain barrier drug permeability: a special focus on transporters and metabolizing enzymes

artículo científico

Hydroxychloroquine and Azithromycin to Treat Patients With COVID-19: Both Friends and Foes?

scientific article published on 20 May 2020

Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells.

artículo científico publicado en 2014

Ibogaine labeling with 99mTc-tricarbonyl: synthesis and transport at the mouse blood-brain barrier.

artículo científico publicado en 2009

Immunoreactivity and pharmacokinetics of horse anti-scorpion venom F(ab')2-scorpion venom interactions

artículo científico publicado en 1996

Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties

artículo científico publicado en 2014

Improved brain delivery of benzylpenicillin with a peptide-vector-mediated strategy

artículo científico publicado en 2002

Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy

artículo científico publicado en 2003

Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy

artículo científico publicado en 2005

In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain.

artículo científico publicado en 2008

In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier

artículo científico publicado en 2004

In vivo saturation of the transport of vinblastine and colchicine by P-glycoprotein at the rat blood-brain barrier

artículo científico publicado en 2003

Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation

scientific journal article

Influence of P-Glycoprotein Inhibition or Deficiency at the Blood-Brain Barrier on (18)F-2-Fluoro-2-Deoxy-D-glucose ( (18)F-FDG) Brain Kinetics

artículo científico publicado en 2015

Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec® ) across the mouse blood-brain barrier

Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes

artículo científico publicado en 2009

Influence of goat colchicine specific antibodies on murine colchicine disposition

artículo científico publicado en 1989

Influence of hydroxyurea on imatinib mesylate (gleevec) transport at the mouse blood-brain barrier

artículo científico publicado en 2006

Influence of various combinations of specific antibody dose and affinity on tissue imipramine redistribution ⬇️

artículo científico publicado en 1998

Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART® Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

artículo científico publicado en 2018

Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).

artículo científico publicado en 2009

Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier

scientific article published on October 2011

Interspecies scaling of clearance and volume of distribution for digoxin-specific Fab.

artículo científico publicado en 1996

Is P-glycoprotein (ABCB1) a phase 0 or a phase 3 colchicine transporter depending on colchicine exposure conditions?

artículo científico publicado en 2006

KCNH2 polymorphism and methadone dosage interact to enhance QT duration

artículo científico publicado en 2014

LC-MS/MS-based quantification of efflux transporter proteins at the BBB

scientific article published on 08 November 2018

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

artículo científico publicado en 2009

Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity

artículo científico publicado en 2015

Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research

artículo científico publicado en 2013

Model-independent pharmacokinetics of colchicine after oral administration to healthy volunteers

artículo científico publicado en 1989

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

artículo científico publicado en 2009

Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar

artículo científico publicado en 2007

Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines

artículo científico publicado en 2002

Morphine pharmacokinetics and pain assessment after intracerebroventricular administration in patients with terminal cancer

artículo científico publicado en 1991

Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat.

artículo científico publicado en 2005

Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats.

artículo científico publicado en 2003

Oatp1a4 and an L-thyroxine-sensitive transporter mediate the mouse blood-brain barrier transport of amyloid-β peptide.

artículo científico publicado en 2013

Opioid transport by ATP-binding cassette transporters at the blood-brain barrier: implications for neuropsychopharmacology

artículo científico

Optimisation of digoxin posology (author's transl)

artículo científico publicado el 1 de marzo de 1981

Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

artículo científico publicado en 2016

Oral absorption characteristics and pharmacokinetics of colchicine in healthy volunteers after single and multiple doses

artículo científico publicado en 1996

P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes

scientific journal article

P2-002 S 18986, a positive modulator of AMPA receptors, crosses the blood brain barrier and it mainly distributes into brain hippocampal cells in rat

Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors

artículo científico publicado en 2002

Peptide vectors as drug carriers.

artículo científico publicado en 2003

Peptide-vector strategy bypasses P-glycoprotein efflux, and enhances brain transport and solubility of paclitaxel

artículo científico publicado en 2004

Pharmacokinetics and organ distribution of cationized colchicine-specific IgG and Fab fragments in rat

artículo científico publicado en 1999

Pharmacokinetics of Vipera aspis venom after experimental envenomation in rabbits

scientific article published on 01 March 1994

Pharmacokinetics of colchicine: a review of experimental and clinical data

artículo científico publicado en 1992

Pharmacokinetics of digoxin‐specific Fab: effects of decreased renal function and age ⬇️

artículo científico publicado el 1 de agosto de 1997

Pharmacokinetics of lithium in plasma and red blood cells in acute and chronic intoxicated patients

artículo científico publicado el 1 de junio de 1995

Pharmacokinetics of oral digoxin. Influence of congestive heart failure and age of patients (author's transl)

artículo científico publicado el 1 de marzo de 1981

Pharmacokinetics of total and free digoxin and Fab fragments in 5 intoxicated patients after administration of specific anti-digoxin Fab fragments

artículo científico publicado en 1991

Pharmacokinetics of unchanged morphine in normal and cirrhotic subjects.

artículo científico publicado en 1987

Pharmacology of morphine in obese patients: clinical implications

artículo científico publicado en 2009

Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line

artículo científico publicado en 2015

Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach

artículo científico publicado en 2013

Plasma concentration of digoxin and digitoxin in elderly : correlation with clinical toxicity (author's transl)

artículo científico publicado el 1 de enero de 1981

Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats.

artículo científico publicado en 2009

Possible role of ABCB1 in lysosomal accumulation of azithromycin in COVID-19 therapy

scientific article published on 17 August 2020

Preclinical Assessment of Immunoreactivity of a New Purified Equine F(ab ′)2 against European Viper Venom ⬇️

artículo científico publicado el 1 de febrero de 1998

Prognosis and treatment of paraquat poisoning: a review of 28 cases

artículo científico publicado en 1982

Prognostic value of plasma and urine paraquat concentration

artículo científico publicado en 1987

Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

artículo científico publicado en 2016

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model

artículo científico publicado en 2012

Radioimmunoassay for Colchicine: Synthesis and Properties of Three Haptens ⬇️

artículo científico publicado el 1 de enero de 1980

Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.

artículo científico publicado en 2012

Reversal of murine colchicine toxicity by colchicine-specific Fab fragments

artículo científico publicado en 1991

Role of ABC transporters in the chemoresistance of human gliomas.

artículo científico publicado en 2006

Role of P-170 glycoprotein in colchicine brain uptake ⬇️

artículo científico publicado el 1 de julio de 1997

Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line ⬇️

artículo científico publicado el 1 de junio de 1997

Simultaneous microdialysis in brain and blood of the mouse: extracellular and intracellular brain colchicine disposition ⬇️

artículo científico publicado el 9 de marzo de 1998

Simultaneous pharmacokinetics/pharmacodynamics modeling of recombinant human erythropoietin upon multiple intravenous dosing in rats

artículo científico publicado en 2010

Single- and repeated-dose pharmacokinetics of intramuscular thiocolchicoside in healthy volunteers

scientific article published on 01 October 1999

Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

artículo científico publicado en 2008

Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA).

artículo científico publicado en 2009

Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity

artículo científico publicado en 2004

Targeted unlabeled multiple reaction monitoring analysis of cell markers for the study of sample heterogeneity in isolated rat brain cortical microvessels.

artículo científico publicado en 2017

The effect of colchicine-specific active immunization on colchicine toxicity and disposition in the rabbit

artículo científico publicado en 1989

The effect of morbid obesity on morphine glucuronidation

artículo científico publicado en 2016

The effect of morbid obesity on morphine glucuronidation

artículo científico publicado en 2016

The human and rat recombinant receptors for advanced glycation end products have a high degree of homology but different pharmacokinetic properties in rats.

artículo científico publicado en 1999

Time-dependent clearance and hematological pharmacodynamics upon erythropoietin multiple dosing in rats

artículo científico publicado en 2010

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels

artículo científico publicado en 2011

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2

artículo científico publicado en 2012

Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening.

artículo científico publicado en 2011

Transporters in absorption, distribution, and elimination

artículo científico publicado en 2009

Vector-mediated drug delivery to the brain

artículo científico publicado en 2001

[Endogenous or "digoxin-like" digitalis compounds. Physiopathological, analytical and pharmacokinetic impact]

artículo científico publicado en 1988

[Immunotherapy of drug poisoning]

scientific article published on 01 January 1994

[Immunotoxicotherapy: protective effect of anti-colchicine antibodies in acute colchicine poisoning in rabbits and mice]

artículo científico publicado en 1986

[Optimization of the dosage of digoxin. Proposal for a minimal exploratory protocol]

[Prognostic factors in acute digitalis poisoning]

artículo científico publicado en 1982

[Recent advances in quantitative proteomics as a sensitive tool to quantify drug transporters and drug metabolizing enzymes at the human blood-brain barrier]

artículo científico publicado en 2012

[Reversibility of severe digitoxin poisoning with antidigoxin antibodies]

scientific article published on 01 January 1983

[¹¹C]befloxatone brain kinetics is not influenced by Bcrp function at the blood-brain barrier: a PET study using Bcrp TGEM knockout rats

artículo científico publicado en 2013

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