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(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

artículo científico publicado en 2007

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

artículo científico publicado en 2002

2-Methylacyl racemase: a coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver ⬇️

artículo científico publicado el 12 de julio de 1997

5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids

artículo científico publicado en 2004

A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide

artículo científico publicado en 2012

Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution

artículo científico publicado en 2013

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

artículo científico publicado en 2008

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities

scientific journal article

Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.

artículo científico publicado en 2013

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

artículo científico publicado en 2019

Aging, age-related diseases and peroxisomes

artículo científico

Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.

artículo científico publicado en 2017

Alpha‐oxidation of 3‐methyl‐substituted fatty acids and its thiamine dependence ⬇️

artículo científico publicado el 1 de abril de 2003

Alterations in phosphatidylethanolamine levels affect the generation of Aβ.

artículo científico publicado en 2011

Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis

artículo científico publicado en 2005

Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay

artículo científico publicado en 2002

Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase

artículo científico publicado en 2007

Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts

scientific journal article

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions

artículo científico publicado en 2015

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

artículo científico publicado en 2010

Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids

artículo científico publicado en 2005

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression

artículo científico publicado en 2011

Central nervous system pathology in MFP2 deficiency: insights from general and conditional knockout mouse models.

artículo científico publicado en 2013

Ceramide-dependent release of ceramide kinase from cultured cells

artículo científico publicado en 2007

Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice

artículo científico publicado en 2017

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis

artículo científico publicado en 2017

Combined deficiency of peroxisomal beta-oxidation and ether lipid synthesis in mice causes only minor cortical neuronal migration defects but severe hypotonia

artículo científico publicado en 2010

Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b

artículo científico publicado en 2008

Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice

artículo científico publicado en 2008

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

artículo científico publicado en 2010

Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting

scientific article published on 24 May 2019

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

artículo científico publicado en 2008

Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process

artículo científico publicado en 2008

Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice

artículo científico publicado en 2011

Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry

artículo científico publicado en 2012

Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice

artículo científico publicado en 2005

Differential activities of peroxisomes along the mouse intestinal epithelium

artículo científico publicado en 2017

Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina

artículo científico publicado en 2019

Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2 ⬇️

artículo científico publicado el 15 de marzo de 1998

Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.

artículo científico publicado en 2009

Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation

artículo científico publicado en 2009

Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex

artículo científico publicado en 2019

Editorial Expression of Concern: Glial β-Oxidation regulates Drosophila Energy Metabolism

artículo científico publicado en 2020

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts

artículo científico publicado en 2010

Enzymatic Quantitation of Cholesterol Esters in Lipid Extracts ⬇️

artículo científico publicado el 10 de abril de 1998

Erratum: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells

scientific article published in Nature

Evidence for the existence of a pristanoyl-CoA oxidase gene in man ⬇️

artículo científico publicado el 1 de agosto de 1997

Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal β-oxidation of pristanic acid ⬇️

artículo científico publicado el 15 de julio de 1997

Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats

artículo científico publicado en 2011

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

artículo científico publicado en 2015

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

artículo científico publicado en 2015

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

artículo científico publicado en 2003

Functional peroxisomes are required for β-cell integrity in mice

artículo científico publicado en 2019

Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins

artículo científico publicado en 2002

Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies

artículo científico publicado en 2005

Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: implications for Refsum disease?

artículo científico publicado en 2003

Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion

artículo científico publicado en 2009

Generalised and conditional inactivation of Pex genes in mice

artículo científico publicado en 2006

Glial β-oxidation regulates Drosophila energy metabolism

artículo científico publicado en 2015

Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice

artículo científico publicado en 2013

Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice.

artículo científico publicado en 2012

Hepatic dysfunction in peroxisomal disorders

artículo científico

Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis.

artículo científico publicado en 2011

Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

artículo científico publicado en 2016

Identification and characterization of new long chain acyl-CoA dehydrogenases

artículo científico publicado en 2011

Identification of a Novel Human Peroxisomal 2,4-Dienoyl-CoA Reductase Related Protein Using the M13 Phage Protein VI Phage Display Technology ⬇️

artículo científico publicado el 1 de noviembre de 2001

Identification of a novel PEX14 mutation in Zellweger syndrome

artículo científico publicado en 2009

Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative

scientific journal article

Intellectual disability, muscle weakness and characteristic face in three siblings: A newly described recessive syndrome mapping to 3p24.3-p25.3.

artículo científico publicado en 2015

Intracellular Growth Hormone Receptors in Chicken Liver ⬇️

artículo científico publicado el 15 de mayo de 1998

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

artículo científico publicado en 2011

Lessons from knockout mice. I: Phenotypes of mice with peroxisome biogenesis disorders.

artículo científico publicado en 2003

Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment

artículo científico publicado en 2019

Lipase‐based quantitation of triacylglycerols in cellular lipid extracts: Requirement for presence of detergent and prior separation by thin‐layer chromatography ⬇️

artículo científico publicado el 1 de diciembre de 1997

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency

artículo científico publicado en 2017

Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction.

artículo científico publicado en 2016

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

scientific journal article

Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders

artículo científico publicado en 2004

Metabolism of dolichol, dolichoic acid and nordolichoic acid in cultured cells ⬇️

artículo científico publicado el 12 de julio de 1997

Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system

artículo científico

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

artículo científico publicado en 2013

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

artículo científico publicado en 2014

Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites

artículo científico publicado en 2017

Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus

artículo científico publicado en 2011

Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies

artículo científico publicado en 2012

N-acyl migration in ceramides

artículo científico publicado en 2005

Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues

scientific journal article

Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice

artículo científico publicado en 2008

Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells

artículo científico publicado en 2021

Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance

artículo científico publicado en 2017

On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase

artículo científico publicado en 2007

Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal b ⬇️

artículo científico publicado el 18 de septiembre de 2003

PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein

artículo científico publicado en 2013

PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells

scientific article published in PLoS ONE

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.

artículo científico publicado en 2017

Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk

artículo científico publicado en 2020

Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

artículo científico publicado en 2021

Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice

scientific journal article

Peroxisomal multifunctional protein-2 deficiency causes motor deficits and glial lesions in the adult central nervous system

artículo científico publicado en 2006

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

artículo científico publicado en 2013

Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model

artículo científico publicado en 2006

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

artículo científico publicado en 2012

Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone

artículo científico publicado en 2012

Peroxisome deficient invertebrate and vertebrate animal models

artículo científico publicado en 2013

Peroxisome dynamics in cultured mammalian cells.

artículo científico publicado en 2009

Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity

artículo científico publicado en 2007

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.

artículo científico publicado en 2017

Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

scientific article published on 21 January 2014

Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase

artículo científico publicado en 2017

Potential role for Pex19p in assembly of PTS-receptor docking complexes

artículo científico publicado en 2004

Presence of thiamine pyrophosphate in mammalian peroxisomes

artículo científico publicado en 2007

Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry

artículo científico publicado en 2018

RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1.

artículo científico publicado en 2013

Redox interplay between mitochondria and peroxisomes

artículo científico publicado en 2015

Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression

artículo científico publicado en 2014

Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging

artículo científico publicado en 2011

Role of PFKFB3-driven glycolysis in vessel sprouting

artículo científico publicado en 2013

Role of alpha-methylacyl coenzyme A racemase in the degradation of methyl-branched alkanes by Mycobacterium sp. strain P101

artículo científico publicado en 2004

Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase

artículo científico publicado en 2011

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.

artículo científico publicado en 2014

S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake

artículo científico publicado en 2008

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid

scientific article published on 24 March 2020

Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.

artículo científico publicado en 2009

Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis

artículo científico publicado en 2011

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

artículo científico publicado en 2017

Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner.

artículo científico publicado en 2005

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.

artículo científico publicado en 2003

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

artículo científico publicado en 2007

Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons

artículo científico publicado en 2009

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase

artículo científico publicado en 2009

Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18

artículo científico publicado en 2009

Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity

artículo científico publicado en 2009

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases

artículo científico publicado en 2011

The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p

artículo científico publicado en 2002

The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid.

artículo científico publicado en 2015

Thiamine pyrophosphate: an essential cofactor in the mammalian metabolism of 3-methyl-branched fatty acids--implications for thiamine deficiencies?

artículo científico publicado en 2003

Training in the fasted state improves glucose tolerance during fat-rich diet

artículo científico publicado en 2010

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts.

artículo científico publicado en 2014

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