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A giant leap in sequence space reveals the intracellular complexities of evolving a new function

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

artículo científico publicado en 2023

Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug

artículo científico publicado en 2020

Discovery and directed evolution of nitroreductase enzymes for activation of prodrugs and PET imaging compounds

2017 doctoral thesis by Michelle Hedley Rich at Victoria University of Wellington

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

artículo científico publicado en 2019

Engineering the <i>Escherichia coli</i> Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

artículo científico publicado en 2021

Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.

artículo científico publicado en 2017

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

artículo científico publicado en 2020

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

artículo científico publicado en 2018

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

artículo científico publicado en 2020

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

artículo científico

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