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A giant leap in sequence space reveals the intracellular complexities of evolving a new function

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

artículo científico publicado en 2013

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

artículo científico publicado en 2019

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.

artículo científico publicado en 2017

Error-prone PCR and effective generation of gene variant libraries for directed evolution

artículo científico publicado en 2014

Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy

artículo científico publicado en 2018

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

artículo científico publicado en 2020

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

artículo científico publicado en 2020

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

artículo científico

Rapid and flexible biochemical assays for evaluating 4'-phosphopantetheinyl transferase activity.

artículo científico publicado en 2011

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

artículo científico publicado en 2016

Site-saturation mutagenesis by overlap extension PCR.

artículo científico publicado en 2014

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

artículo científico publicado en 2013

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