Lista de obras -

1646. Combined Resistance Analyses From Phase 2b Studies of Presatovir Treatment in RSV-Infected Adults

A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infe

scientific article published on 03 December 2019

A novel inhibitor of dengue virus replication that targets the capsid protein

artículo científico publicado en 2012

A phase 2, randomized, double-blind, placebo-controlled trial of presatovir for the treatment of respiratory syncytial virus upper respiratory tract infection in hematopoietic-cell transplant recipients

scientific article published on 03 December 2019

Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures

artículo científico publicado en 2007

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge

artículo científico publicado en 2005

Anti-HBV activity of retinoid drugs in vitro versus in vivo

scientific article published on 19 June 2019

Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection

artículo científico publicado en 2015

Antiviral Potency of ST-246 on the Production of Enveloped Orthopoxviruses and Characterization of ST-246 Resistant Vaccinia, Cowpox and Camelpox Viruses

article

Assessment of drug resistance during phase 2b clinical trials of presatovir in adults naturally infected with respiratory syncytial virus

scientific article published on 18 February 2020

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

artículo científico publicado en 2017

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

artículo científico publicado en 2017

Characterization of the mode of action of a potent dengue virus capsid inhibitor

artículo científico publicado en 2014

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

artículo científico publicado en 2020

Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys ⬇️

artículo científico publicado el 15 de agosto de 2011

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

artículo científico publicado en 2018

Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge ⬇️

artículo científico publicado el 25 de noviembre de 2011

Development of ST-246® for Treatment of Poxvirus Infections ⬇️

artículo científico publicado el 3 de noviembre de 2010

Development of the Small-Molecule Antiviral ST-246 ® as a Smallpox Therapeutic ⬇️

artículo científico publicado el 1 de mayo de 2011

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

artículo científico publicado en 2017

Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study

artículo científico publicado en 2015

Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches

artículo científico publicado en 2007

Drug resistance assessment following administration of RSV fusion inhibitor presatovir to participants experimentally infected with respiratory syncytial virus

scientific article published on 23 January 2020

Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus ⬇️

artículo científico publicado el 22 de junio de 2011

Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice

artículo científico publicado en 2006

Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.

artículo científico publicado en 2007

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox

artículo científico publicado en 2012

Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model

artículo científico publicado en 2008

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

artículo científico publicado en 2017

GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process

artículo científico publicado en 2015

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

artículo científico publicado en 2015

Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.

artículo científico publicado en 2002

Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination

artículo científico publicado en 2007

Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice ⬇️

artículo científico publicado el 29 de octubre de 2010

In vitro efficacy of ST246 against smallpox and monkeypox

artículo científico publicado en 2008

Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246®.

artículo científico publicado en 2012

Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions

artículo científico publicado en 2002

Meeting report: 32nd International Conference on Antiviral Research

scientific article published on 11 July 2019

Molecular viral oncology of hepatocellular carcinoma

artículo científico publicado en 2003

Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C

artículo científico publicado en 2013

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors

artículo científico publicado en 2007

Newly synthesized hepatitis C virus replicon RNA is protected from nuclease activity by a protease-sensitive factor(s).

artículo científico publicado en 2004

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

scientific article published on 06 April 2009

Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase

artículo científico publicado en 2013

Oral GS-5806 activity in a respiratory syncytial virus challenge study.

artículo científico publicado en 2014

Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans

artículo científico publicado en 2012

Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers

artículo científico publicado en 2012

Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection

artículo científico publicado en 2013

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

artículo científico publicado en 2020

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

artículo científico publicado en 2019

Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells

artículo científico publicado en 2002

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.

artículo científico publicado en 2012

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

artículo científico publicado en 2003

ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification

artículo científico publicado en 2009

ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation

artículo científico publicado en 2009

Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers

artículo científico publicado en 2012

Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects

artículo científico publicado en 2010

Severe eczema vaccinatum in a household contact of a smallpox vaccinee

artículo científico publicado en 2008

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

artículo científico publicado en 2008

Smallpox antiviral drug development: satisfying the animal efficacy rule

artículo científico publicado en 2006

Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently

artículo científico publicado en 2008

Stability and circularization of herpes simplex virus type 1 genomes in quiescently infected PC12 cultures

artículo científico publicado en 2002

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses

artículo científico publicado en 2007

The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy

artículo científico publicado en 2002

The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus

artículo científico publicado en 2007

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

artículo científico publicado en 2016

Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis

artículo científico publicado en 2009

Lista de obras de

1646. Combined Resistance Analyses From Phase 2b Studies of Presatovir Treatment in RSV-Infected Adults

A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infe

A novel inhibitor of dengue virus replication that targets the capsid protein

A phase 2, randomized, double-blind, placebo-controlled trial of presatovir for the treatment of respiratory syncytial virus upper respiratory tract infection in hematopoietic-cell transplant recipients

Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge

Anti-HBV activity of retinoid drugs in vitro versus in vivo

Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection

Antiviral Potency of ST-246 on the Production of Enveloped Orthopoxviruses and Characterization of ST-246 Resistant Vaccinia, Cowpox and Camelpox Viruses

Assessment of drug resistance during phase 2b clinical trials of presatovir in adults naturally infected with respiratory syncytial virus

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Characterization of the mode of action of a potent dengue virus capsid inhibitor

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys ⬇️

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge ⬇️

Development of ST-246® for Treatment of Poxvirus Infections ⬇️

Development of the Small-Molecule Antiviral ST-246 ® as a Smallpox Therapeutic ⬇️

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study

Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches

Drug resistance assessment following administration of RSV fusion inhibitor presatovir to participants experimentally infected with respiratory syncytial virus

Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus ⬇️

Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice

Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox

Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.

Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination

Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice ⬇️

In vitro efficacy of ST246 against smallpox and monkeypox

Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246®.

Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions

Meeting report: 32nd International Conference on Antiviral Research

Molecular viral oncology of hepatocellular carcinoma

Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors

Newly synthesized hepatitis C virus replicon RNA is protected from nuclease activity by a protease-sensitive factor(s).

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase

Oral GS-5806 activity in a respiratory syncytial virus challenge study.

Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans

Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers

Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification

ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation

Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers

Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects

Severe eczema vaccinatum in a household contact of a smallpox vaccinee

Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor

Smallpox antiviral drug development: satisfying the animal efficacy rule

Specific targeting of the F13L protein by ST-246 affects orthopoxvirus production differently

Stability and circularization of herpes simplex virus type 1 genomes in quiescently infected PC12 cultures

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses

The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy

The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis