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'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA.

artículo científico publicado en 2015

A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis

artículo científico publicado en 2013

A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice

artículo científico publicado en 2007

A critical role for murine complement regulator crry in fetomaternal tolerance

scientific journal article

A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.

artículo científico publicado en 2010

A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.

artículo científico publicado en 1990

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

artículo científico publicado en 2009

A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22

scientific article published on 20 October 2016

A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease

artículo científico publicado en 2015

A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice

artículo científico publicado en 2017

A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice

artículo científico publicado en 2005

A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury

artículo científico publicado en 2020

A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice

scientific article published on 20 December 2011

A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury

artículo científico publicado en 2008

A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA.

artículo científico publicado en 2009

A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration

artículo científico publicado en 2010

Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis

artículo científico publicado en 2010

Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking

artículo científico publicado en 2016

Activation of complement mediates antiphospholipid antibody-induced pregnancy loss

artículo científico publicado en 2003

Acute tubular necrosis is characterized by activation of the alternative pathway of complement

artículo científico publicado en 2005

Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice

artículo científico publicado en 2003

Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis

artículo científico publicado en 2003

Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.

artículo científico publicado en 2006

Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia

artículo científico publicado en 2008

Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis

artículo científico publicado en 2006

Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome

artículo científico publicado en 2009

An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks

artículo científico publicado en 2014

Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2.

artículo científico publicado en 1994

Analysis of C3b/C4b receptor (CR1) polymorphic variants by tryptic peptide mapping

artículo científico publicado en 1986

Analysis of Epstein-Barr virus-binding sites on complement receptor 2 (CR2/CD21) using human-mouse chimeras and peptides. At least two distinct sites are necessary for ligand-receptor interaction ⬇️

artículo científico publicado el 5 de julio de 1991

Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells

scientific article published on 01 August 1989

Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility

artículo científico publicado en 2015

Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs) ⬇️

artículo científico publicado el 1 de febrero de 1992

Annexin A2 Enhances Complement Activation by Inhibiting Factor H

artículo científico publicado en 2016

Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus

artículo científico publicado en 2004

Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients

artículo científico publicado en 2017

Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis.

artículo científico publicado en 2015

Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice.

artículo científico publicado en 2004

Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis

artículo científico publicado en 2006

Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis

artículo científico publicado en 2005

Antibodies to citrullinated proteins: pathogenic and diagnostic significance

artículo científico publicado en 2007

Antibody Responses to Citrullinated and Non-Citrullinated Antigens in the Sputum of Subjects with and At-Risk for Rheumatoid Arthritis.

artículo científico publicado en 2017

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis.

scientific article published on 09 October 2008

Anticyclic Citrullinated Peptide Antibodies 3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis

scientific article published on 15 April 2019

Anti–cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis

scientific article published on 01 September 2006

Are anti-cyclic citrullinated peptide antibodies pathogenic in rheumatoid arthritis?

artículo científico publicado en 2006

Arthritis critically dependent on innate immune system players

artículo científico publicado en 2002

Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion

artículo científico publicado en 2010

Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis

artículo científico publicado en 2017

Association of lipid mediators and development of future incident inflammatory arthritis in an anti-citrullinated protein antibody positive population

scientific article published on 31 December 2020

Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis

artículo científico publicado en 2016

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

artículo científico publicado en 2019

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity

artículo científico publicado en 2019

Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis

artículo científico publicado en 2012

Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis

artículo científico publicado en 2013

Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. ⬇️

artículo científico publicado en 2010

B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion

artículo científico publicado en 2010

B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens

artículo científico publicado en 2005

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury

artículo científico publicado en 2011

Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP.

artículo científico publicado en 2014

Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair

artículo científico publicado en 2010

Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor ⬇️

artículo científico publicado el 1 de mayo de 1998

Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity?

artículo científico publicado en 2011

C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice

scientific article published on 16 October 2020

C3 glomerulopathy: consensus report

artículo científico publicado en 2013

C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion

artículo científico publicado en 2007

CD4 + T Cells and Complement Independently Mediate Graft Ischemia in the Rejection of Mouse Orthotopic Tracheal Transplants ⬇️

artículo científico publicado el 13 de octubre de 2011

CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE

artículo científico publicado en 2004

CR2

CR2-C3D COMPLEX STRUCTURE

CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation ⬇️

artículo científico publicado el 1 de enero de 2013

CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues

artículo científico publicado en 2006

Can we accurately predict the development of rheumatoid arthritis in the preclinical phase?

artículo científico publicado en 2003

Candidate inhibitors of porcine complement

artículo científico publicado en 2006

Challenges and Opportunities: Using Omics to Generate Testable Insights into Pathogenic Mechanisms in Preclinical Seropositive Rheumatoid Arthritis

artículo científico publicado en 2020

Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury.

artículo científico publicado en 2012

Characterization of C3 receptors on cultured rat glomerular endothelial cells

artículo científico

Characterization of C3-binding proteins on mouse neutrophils and platelets ⬇️

artículo científico publicado el 1 de septiembre de 1997

Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules

artículo científico publicado en 1995

Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus

scientific article published on 01 July 2006

Characterization of rat complement receptors and regulatory proteins. CR2 and Crry are conserved, and the C3b receptor of neutrophils and platelets is distinct from CR1 ⬇️

artículo científico publicado el 1 de agosto de 1995

Cigarette smoking, disease severity and autoantibody expression in African Americans with recent-onset rheumatoid arthritis.

artículo científico publicado en 2008

Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF

artículo científico publicado en 2020

Clinical utility of complement biomarkers in the diagnosis and treatment of acute thrombotic microangiopathies

artículo científico publicado en 2014

Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement

artículo científico publicado en 1987

Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway

scientific article published on 01 March 2005

Combination of anti-citrullinated protein antibodies and rheumatoid factor is associated with increased systemic inflammatory mediators and more rapid progression from preclinical to clinical rheumatoid arthritis

artículo científico publicado en 2018

Complement Activation in the Vitreous of Patients With Proliferative Diabetic Retinopathy

scientific article published on 01 September 2020

Complement C3 activation is required for antiphospholipid antibody-induced fetal loss

artículo científico publicado en 2002

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

artículo científico publicado en 2003

Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis

artículo científico publicado en 2002

Complement activation fragment Bb in early pregnancy and spontaneous preterm birth

artículo científico publicado en 2008

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

artículo científico publicado en 2006

Complement activation is critical to airway hyperresponsiveness after acute ozone exposure

artículo científico publicado en 2003

Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis ⬇️

artículo científico publicado el 4 de abril de 2012

Complement and its environmental determinants in the progression of human rheumatoid arthritis

scientific article published on 15 June 2019

Complement and its receptors: new insights into human disease

artículo científico publicado en 2014

Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice

scientific article published on 01 May 2001

Complement component c5a is integral to the febrile response of mice to lipopolysaccharide

artículo científico publicado en 2005

Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.

artículo científico publicado en 2018

Complement in the Initiation and Evolution of Rheumatoid Arthritis.

artículo científico publicado en 2018

Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice

scientific journal article

Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure

scientific article published on 01 October 2000

Complement is an essential component of the immune response to adeno-associated virus vectors

artículo científico publicado en 2008

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

artículo científico publicado en 2016

Complement receptor 2 and autoimmunity

artículo científico publicado en 2004

Complement receptor 2, natural antibodies and innate immunity: Inter-relationships in B cell selection and activation

artículo científico publicado en 2006

Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation

artículo científico publicado en 2003

Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation

Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens

artículo científico publicado en 2008

Complement receptor chimaeric conjugate CR2-Ig

Complement receptors

artículo científico publicado en 1992

Complement receptors and the shaping of the natural antibody repertoire

artículo científico publicado en 2004

Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells

artículo científico publicado en 1995

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

artículo científico publicado en 2019

Correction: Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

scholarly article by Jeremy Sokolove et al published 28 August 2012 in PLOS ONE

Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein

artículo científico publicado en 2001

Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis

scientific article published on 01 April 1995

Crry-IG, an inhibitor of C3 activation, blocks anti-phospholipid AB (aPL) induced fetal loss

Crry-Ig, a complement activation inhibitor, protects mice from ischemia /reperfusion (IR) induced intestinal injury

Cutting edge: Complement (C3d)-linked antigens break B cell anergy

scientific article published on 01 September 2007

Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.

artículo científico publicado en 2017

Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice

artículo científico publicado en 2009

Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3.

artículo científico publicado en 2007

Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury

artículo científico publicado en 2014

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

artículo científico publicado en 2019

Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking

scientific article published on 14 October 2010

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway–mediated diseases ⬇️

artículo científico publicado el 22 de agosto de 2011

Detection of complement activation using monoclonal antibodies against C3d.

artículo científico publicado en 2013

Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis

artículo científico

Disruptive innovation in rheumatology: new networks of global public-private partnerships are needed to take advantage of scientific progress

scientific article published on 05 March 2020

Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1 ⬇️

artículo científico publicado el 1 de enero de 1992

Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

artículo científico publicado en 2016

Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis

artículo científico publicado en 2007

Early Elevations of the Complement Activation Fragment C3a and Adverse Pregnancy Outcomes ⬇️

artículo científico publicado el 1 de enero de 2011

Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?

artículo científico publicado en 2017

Effects of complement factor D deficiency on the renal disease of MRL/lpr mice

artículo científico publicado en 2004

Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis.

artículo científico publicado en 2016

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease

artículo científico publicado en 2018

Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli

scientific article published on 01 July 2001

Epitope Mapping Using the X-Ray Crystallographic Structure of Complement Receptor Type 2 (CR2)/CD21: Identification of a Highly Inhibitory Monoclonal Antibody That Directly Recognizes the CR2-C3d Interface

scientific article published on 01 November 2001

Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells

artículo científico publicado en 2010

Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression

artículo científico publicado en 2014

Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis

artículo científico publicado en 2010

Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis

artículo científico publicado en 2013

Evidence for non-traditional activation of complement factor C3 during murine liver regeneration

artículo científico publicado en 2008

Excessive Matrix Accumulation in the Kidneys of MRL/lpr Lupus Mice Is Dependent on Complement Activation ⬇️

artículo científico publicado el 1 de octubre de 2003

Expression and function of membrane regulators of complement on rat astrocytes in culture

artículo científico publicado en 1996

Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure.

artículo científico publicado en 2001

Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response ⬇️

artículo científico publicado el 1 de junio de 1998

Expression of human complement receptor type 2 (CD21) in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia.

artículo científico publicado en 2002

Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy

artículo científico publicado en 2005

Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation

artículo científico publicado en 2006

Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting

scientific article published on 14 September 2020

Functional analysis of the human complement receptor 2 (CR2/CD21) promoter: characterization of basal transcriptional mechanisms

artículo científico publicado en 2002

Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes

artículo científico publicado en 1998

Generation of novel C3dg tetramers for the analysis of CD21 binding and function

Genetic and environmental risk factors for rheumatoid arthritis

artículo científico publicado en 2017

Genetics of the complement system and rheumatic diseases

artículo científico publicado el 1 de noviembre de 1992

Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor

artículo científico publicado en 1989

Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases

artículo científico publicado en 2007

Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis

artículo científico publicado en 2020

Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity

artículo científico publicado en 1987

Human C3 glomerulopathy provides unique insights into complement factor H-related protein function

artículo científico publicado en 2013

Human C3b- and C4b-regulatory proteins: a new multi-gene family

artículo científico

Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study

artículo científico publicado en 2017

Human complement C3b/C4b receptor (CR1) mRNA polymorphism that correlates with the CR1 allelic molecular weight polymorphism

artículo científico publicado en 1987

Human complement receptor 2 (CR2/CD21) as a receptor for DNA: Implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE) ⬇️

artículo científico publicado el 10 de agosto de 2012

Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists

artículo científico publicado en 2011

Identification of a central role for complement in osteoarthritis

artículo científico publicado en 2011

Identification of a third component of complement-binding glycoprotein of human platelets

artículo científico publicado en 1986

Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1

artículo científico publicado en 1988

Identification of undiagnosed inflammatory arthritis in a community health fair screen

artículo científico publicado en 2009

IgM Contributes to Glomerular Injury in FSGS ⬇️

artículo científico publicado el 7 de febrero de 2013

IgM exacerbates glomerular disease progression in complement-induced glomerulopathy

artículo científico publicado en 2015

Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension

artículo científico publicado en 2020

In Memorium for William Arend, former A&R Editor-in-Chief

artículo científico publicado en 2020

In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms

artículo científico publicado en 2017

Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21).

artículo científico publicado en 2009

Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects

artículo científico publicado en 2004

Induction of peri-insulitis but not diabetes in islet transplants expressing a single foreign antigen. A multi-stage model of disease

artículo científico publicado en 1993

Inhibiting the complement system does not reduce injury in renal ischemia reperfusion

artículo científico publicado en 2001

Inhibition of Complement Activation Decreases Airway Inflammation and Hyperresponsiveness ⬇️

artículo científico publicado el 18 de septiembre de 2003

Inhibition of ischemia reperfusion-induced intestinal injury and systemic inflammation by a novel complement regulatory protein

Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

artículo científico publicado en 2007

Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies

artículo científico publicado en 2008

Innate autoimmunity

artículo científico publicado en 2005

Insights from populations at risk for the future development of classified rheumatoid arthritis

artículo científico publicado en 2014

Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development

scientific article published on 01 March 2007

Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21).

artículo científico publicado en 2007

Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D

scientific article published on 21 February 2020

Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice

artículo científico publicado en 2003

Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients

Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study

artículo científico publicado en 2015

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

artículo científico publicado en 2018

Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing.

artículo científico publicado en 2016

Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis

artículo científico publicado en 2009

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions

artículo científico publicado en 2016

Mechanisms of effects of complement inhibition in murine collagen-induced arthritis

artículo científico publicado en 2002

Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement

artículo científico publicado en 2011

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

artículo científico publicado en 2018

Methotrexate and rheumatoid arthritis associated interstitial lung disease

artículo científico publicado en 2020

Mice Deficient in Complement Receptors 1 and 2 Lack a Tissue Injury-Inducing Subset of the Natural Antibody Repertoire

scientific article published on 01 August 2002

Mice expressing human CR1/CD35 have an enhanced humoral immune response to T-dependent antigens but fail to correct the effect of premature human CR2 expression ⬇️

artículo científico publicado el 25 de junio de 2011

Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling

scholarly article published 3 February 2004

Model of rat Crry determined by solution scattering, curve fitting and homology modelling

scholarly article published 3 February 2004

Modulation of mouse endotoxic fever by complement

artículo científico publicado en 2002

Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B

scientific article published on 01 January 2000

Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins

artículo científico publicado en 2017

Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake.

scientific article published on 21 October 2015

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.

artículo científico publicado en 2008

Mouse Crry/p65 is a regulator of the alternative pathway of complement activation

scientific article published on 01 June 1993

Mouse Crry/p65. Characterization of monoclonal antibodies and the tissue distribution of a functional homologue of human MCP and DAF ⬇️

artículo científico publicado el 15 de octubre de 1993

Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo.

artículo científico publicado en 2004

Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice ⬇️

artículo científico publicado el 1 de agosto de 1997

Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein

artículo científico publicado en 1995

Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA)

artículo científico publicado en 2012

Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.

artículo científico publicado en 2005

N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.

artículo científico publicado en 2011

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

artículo científico publicado en 2017

New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities

artículo científico publicado en 2016

Nomenclature for the Phases of the Development of Rheumatoid Arthritis

scientific article published on 10 June 2019

Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells

artículo científico publicado en 1988

Novel inhibitory monoclonal antibodies to human CR2/CD21 ligand binding domains

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

scientific article published on 17 May 2016

Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications ⬇️

artículo científico publicado el 1 de noviembre de 2010

Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis

artículo científico publicado en 2004

Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.

scientific article published on 21 April 2009

Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner

artículo científico publicado en 2013

Pathogenic Natural Antibodies Propagate Cerebral Injury Following Ischemic Stroke in Mice ⬇️

artículo científico publicado el 23 de diciembre de 2011

Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway

scientific article published on 01 September 2007

Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury

artículo científico publicado en 2009

Perceived stress and inflammatory arthritis: a prospective investigation in the Studies of the Etiologies of Rheumatoid Arthritis (SERA) cohort

scientific article published on 10 October 2019

Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease

artículo científico publicado en 2013

Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population

artículo científico publicado en 2007

Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury

artículo científico publicado en 2006

Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.

scientific article published on 13 March 2009

Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients.

artículo científico publicado en 2018

Polymorphisms of the regulators of complement activation gene cluster.

artículo científico publicado en 1990

Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis

artículo científico publicado en 2012

Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile

artículo científico publicado en 2012

Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation

artículo científico publicado en 2010

Predicting and preventing the development of rheumatoid arthritis.

artículo científico publicado en 2015

Predictive value of autoantibody testing for validating self-reported diagnoses of rheumatoid arthritis in the Women's Health Initiative

artículo científico publicado en 2013

Preface to the Special issue for the 27th International complement workshop

artículo científico publicado en 2018

Prepregnancy obesity and complement system activation in early pregnancy and the subsequent development of preeclampsia ⬇️

artículo científico publicado el 7 de marzo de 2012

Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y

scientific article published on 01 August 2003

Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

scientific article published on 17 May 2019

Purification and functional analysis of the polymorphic variants of the C3b/C4b receptor (CR1) and comparison with H, C4b-binding protein (C4bp), and decay accelerating factor (DAF)

artículo científico publicado en 1985

REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

artículo científico publicado en 2009

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

artículo científico publicado en 2006

Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA.

artículo científico publicado en 2013

Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis

artículo científico publicado en 2013

Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice

artículo científico publicado en 2010

Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury

artículo científico publicado en 1999

Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative

artículo científico publicado en 2015

Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention - An Emerging Paradigm Shift

artículo científico publicado en 2020

Rheumatoid arthritis (RA)-specific autoantibodies in patients with interstitial lung disease and absence of clinically apparent articular RA.

artículo científico publicado en 2009

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

artículo científico publicado en 2018

Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation

artículo científico publicado en 2014

Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes

artículo científico publicado en 2012

Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis

artículo científico publicado en 2006

Role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissues

scientific article published on 01 June 2007

Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice ⬇️

artículo científico publicado el 28 de diciembre de 2011

Role of CR2- and CD19-regulated natural antibodies in intestinal ischemia reperfusion-induced injury

Role of complement in the development of autoimmunity

artículo científico publicado en 2003

Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling

artículo científico publicado en 2008

Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice

artículo científico publicado en 2013

SPECT/CT Imaging of Mycobacterium tuberculosis Infection with [125I]anti-C3d mAb

artículo científico publicado en 2019

Shared and unique immune alterations in pre-clinical autoimmunity

artículo científico publicado en 2019

Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains

artículo científico publicado en 2016

Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls

artículo científico publicado en 2014

Solution Structure of TT30, a Novel Complement Therapeutic Agent, Provides Insight into Its Joint Binding to Complement C3b and C3d ⬇️

artículo científico publicado el 4 de mayo de 2012

Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study

scientific article published on 12 January 2005

Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2.

artículo científico publicado en 2008

Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation

artículo científico publicado en 2002

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

artículo científico publicado en 2018

Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease

artículo científico publicado en 2013

Structural analysis of recombinant human CD21 ligand binding domains

Structural and functional studies on the human C3b/C4b receptor (CR1) purified by affinity chromatography using a monoclonal antibody

artículo científico publicado en 1986

Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene

artículo científico publicado en 1989

Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg

artículo científico publicado en 2001

Structure of complement receptor 2 in complex with its C3d ligand

artículo científico publicado en 2001

Structure of the Epstein-Barr virus major envelope glycoprotein

artículo científico publicado en 2006

Studies of Filipino patients with systemic lupus erythematosus: Autoantibody profile of first-degree relatives ⬇️

artículo científico publicado el 23 de diciembre de 2010

Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14<sup>hi</sup> monocytes

scientific article published on 09 December 2020

Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis

artículo científico publicado en 2010

Systemic Human CR2-Targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-Induced Choroidal Neovascularization ⬇️

artículo científico publicado el 6 de febrero de 2012

Systemic activation of the complement system in patients with advanced age-related macular degeneration

scientific article published on 17 June 2019

Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection

artículo científico publicado en 2005

Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice

artículo científico publicado en 2009

Targeting mechanisms at sites of complement activation for imaging and therapy

artículo científico publicado en 2015

Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis

artículo científico publicado en 2018

Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury

artículo científico publicado en 2015

Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus

artículo científico publicado en 2019

Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice.

artículo científico publicado en 2013

The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions

artículo científico publicado en 2006

The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness and Inflammation ⬇️

artículo científico publicado el 14 de diciembre de 2011

The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases

artículo científico publicado en 2017

The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture

artículo científico publicado en 2008

The Natural History of Rheumatoid Arthritis

scientific article published on 10 June 2019

The Relationship of Longitudinal Levels of Complement Bb During Pregnancy with Preeclampsia

artículo científico publicado en 2015

The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization ⬇️

artículo científico publicado el 22 de enero de 2011

The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita

artículo científico publicado en 2007

The alternative pathway of complement in disease: opportunities for therapeutic targeting

artículo científico publicado en 2004

The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy

scientific article published on 23 May 2007

The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population

artículo científico publicado en 2017

The central role of the alternative complement pathway in human disease

artículo científico publicado en 2006

The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.

artículo científico publicado en 2010

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

artículo científico publicado en 2012

The complement system as a therapeutic target in autoimmunity

artículo científico publicado en 2003

The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function

artículo científico publicado el 1 de junio de 1992

The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy

artículo científico publicado en 2003

The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.

artículo científico publicado en 1987

The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models

scientific article published on 01 December 2018

The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia

artículo científico publicado en 2010

The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner

artículo científico publicado en 2010

The polymorphism of the C3b/C4b receptor in the normal population and in patients with systemic lupus erythematosus

artículo científico publicado en 1987

The regulators of complement activation (RCA) gene cluster

artículo científico publicado en 1989

The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis

artículo científico publicado en 2018

The relationship of circulating proteins in early pregnancy with preterm birth.

artículo científico publicado en 2015

The role of the immune response in age-related macular degeneration

artículo científico publicado en 2013

The spectrum of complement alternative pathway-mediated diseases

artículo científico publicado en 2008

The structure of human CD23 and its interactions with IgE and CD21.

artículo científico publicado en 2005

Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE ⬇️

artículo científico publicado el 20 de enero de 2013

Timing of Elevations of Autoantibody Isotypes Prior to Diagnosis of Rheumatoid Arthritis

scientific article published on 26 December 2019

Transgenic Mice Overexpressing the Complement Inhibitor Crry as a Soluble Protein Are Protected from Antibody-induced Glomerular Injury ⬇️

artículo científico publicado el 5 de octubre de 1998

Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice

artículo científico publicado en 2002

Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury.

artículo científico publicado en 2006

Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis

artículo científico publicado en 2018

Unique Sjögren's syndrome patient subsets defined by molecular features

scientific article published on 01 April 2020

When and where does inflammation begin in rheumatoid arthritis?

artículo científico publicado en 2014

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