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17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates

scientific article published on 04 November 2019

17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner

artículo científico publicado en 2020

A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.

artículo científico publicado en 2016

Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice

artículo científico publicado en 2006

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice

artículo científico publicado en 2007

Blood Serum From Head and Neck Squamous Cell Carcinoma Patients Induces Altered MicroRNA and Target Gene Expression Profile in Treated Cells.

artículo científico publicado en 2018

Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart

artículo científico publicado en 2006

Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice

artículo científico publicado en 2005

Calorie restriction during gestation affects ovarian reserve in offspring in the mouse

artículo científico publicado en 2020

Cathepsin B Regulates Hepatic Lipid Metabolism by Cleaving Liver Fatty Acid Binding Protein

artículo científico publicado en 2017

Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation

artículo científico publicado en 2016

Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging

artículo científico publicado en 2017

Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes

artículo científico publicado en 2017

Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation

artículo científico publicado en 2007

Circulating microRNA profile in humans and mice with congenital GH deficiency

artículo científico publicado en 2021

Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse

artículo científico publicado en 2015

Circulating small non-coding RNA signature in head and neck squamous cell carcinoma

artículo científico publicado en 2015

Connecting serum IGF-1, body size, and age in the domestic dog ⬇️

artículo científico publicado el 24 de septiembre de 2010

Correction to: Oral Microbial Species and Virulence Factors Associated with Oral Squamous Cell Carcinoma

artículo científico publicado en 2020

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

scientific article published on 18 January 2020

Decreased expression level of apoptosis-related genes and/or proteins in skeletal muscles, but not in hearts, of growth hormone receptor knockout mice

artículo científico publicado en 2011

Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.

artículo científico publicado en 2012

Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation

artículo científico publicado en 2012

Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension

artículo científico publicado en 2011

Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity

artículo científico publicado en 2009

Divergent effects of caloric restriction on gene expression in normal and long-lived mice

artículo científico publicado en 2004

Dwarf Mice and Aging

artículo científico publicado en 2018

EFFECT OF CALORIC RESTRICTION AND RAPAMYCIN ON OVARIAN AGING IN MICE

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice

artículo científico publicado en 2010

Effect of caloric restriction and rapamycin on ovarian aging in mice

artículo científico publicado en 2019

Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice

artículo científico publicado en 2005

Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries.

artículo científico publicado en 2014

Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle

artículo científico publicado en 2007

Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice

artículo científico publicado en 2005

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice

artículo científico publicado en 2005

Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice

artículo científico publicado en 2007

Effects of every-other-day feeding on prolactin regulatory mechanism in transgenic human growth hormone mice

artículo científico publicado en 2008

Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice

artículo científico publicado en 2010

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

artículo científico publicado en 2009

Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma

artículo científico publicado en 2014

Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent

artículo científico publicado en 2014

Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.

artículo científico publicado en 2011

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age.

artículo científico publicado en 2015

Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes

artículo científico publicado en 2009

Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence

artículo científico publicado en 2015

Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver

artículo científico publicado en 2015

Growth Hormone and Aging: New Findings

artículo científico publicado en 2021

Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.

artículo científico publicado en 2014

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

artículo científico publicado en 2014

Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries

artículo científico publicado en 2021

Growth hormone, inflammation and aging

artículo científico publicado en 2012

Growth hormone-mediated reprogramming of macrophage transcriptome and effector functions

artículo científico publicado en 2019

Human Papillomavirus and the use of nanoparticles for immunotherapy in HPV-related cancer: A review

artículo científico publicado en 2019

In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene

artículo científico publicado en 2010

Insulin sensitivity as a key mediator of growth hormone actions on longevity

artículo científico publicado en 2009

Insulin sensitivity in long-living Ames dwarf mice

artículo científico publicado en 2014

Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: effects of calorie restriction

artículo científico publicado en 2008

Interaction of growth hormone and calorie restriction

scientific article published on 01 November 2006

Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?

artículo científico publicado en 2009

Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice

artículo científico publicado en 2011

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

artículo científico publicado en 2014

Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice

artículo científico publicado en 2005

Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics

artículo científico publicado en 2006

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction

artículo científico publicado en 2004

Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure

artículo científico publicado en 2016

Longevity is impacted by growth hormone action during early postnatal period

artículo científico publicado en 2017

Metabolic effects of intra-abdominal fat in GHRKO mice

artículo científico publicado en 2011

MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging

artículo científico publicado en 2009

MicroRNA regulation in colorectal cancer tissue and serum

scientific article published on 30 August 2019

MicroRNAs and the metabolic hallmarks of aging

artículo científico publicado en 2017

Molecular targets for NF1-associated malignant peripheral nerve sheath tumor

scientific article published on 27 April 2020

Multivariate analysis as an advantageous approach for prediction of the adverse outcome in head and neck microvascular reconstructive surgery

artículo científico publicado en 2016

Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change.

artículo científico publicado en 2017

Oral Microbial Species and Virulence Factors Associated with Oral Squamous Cell Carcinoma

artículo científico publicado en 2020

Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice.

artículo científico publicado en 2016

Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.

artículo científico publicado en 2016

PPARs in Calorie Restricted and Genetically Long-Lived Mice

artículo científico publicado en 2007

Paraoxonase 1 serum activity in women: the effects of menopause, the C(-107)T polymorphism and food intake

scientific article published on 25 April 2019

Pioglitazone does not improve insulin signaling in mice with GH over-expression

artículo científico publicado en 2013

Positive fresh frozen section margins as an adverse independent prognostic factor for local recurrence in oral cancer patients

artículo científico publicado en 2017

Post‐transcriptional regulation of IGF1R by key microRNAs in long–lived mutant mice ⬇️

artículo científico publicado el 1 de diciembre de 2011

Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1.

artículo científico publicado en 2015

Primordial follicle activation in the ovary of Ames dwarf mice

artículo científico publicado en 2014

Primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of the long-living Ames dwarf mice

scientific article published on 25 January 2020

Profiling of tRNA Halves and YRNA Fragments in Serum and Tissue From Oral Squamous Cell Carcinoma Patients Identify Key Role of 5' tRNA-Val-CAC-2-1 Half

artículo científico publicado en 2019

RasGrf1: genomic imprinting, VSELs, and aging

artículo científico publicado en 2011

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice

artículo científico publicado en 2015

Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal.

artículo científico publicado en 2011

Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice.

artículo científico publicado en 2015

Self-Assembled STrap for Global Proteomics and Salivary Biomarker Discovery

scientific article published on 21 March 2019

Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice

artículo científico publicado en 2021

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

article by Jamie N Justice et al published February 2019 in EBioMedicine

Skeletal muscle RBM3 expression is associated with extended lifespan in Ames dwarf and calorie restricted mice

artículo científico publicado en 2020

THE GUT MICROBIOME AND AGING

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

THE INFLUENCE OF LIFE-EXTENDING MUTATION AND DIETARY INTERVENTION ON GUT MICROBIOTA

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

THow diet interacts with longevity genes

artículo científico publicado en 2008

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

artículo científico publicado en 2006

The contribution of visceral fat to improved insulin signaling in Ames dwarf mice.

artículo científico publicado en 2014

The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice

artículo científico publicado en 2014

The effect of calorie restriction on the presence of apoptotic ovarian cells in normal wild type mice and low-plasma-IGF-1 Laron dwarf mice

artículo científico publicado en 2013

The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice

artículo científico publicado en 2009

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

scientific article published on 04 September 2019

The importance of stem cell engineering in head and neck oncology

artículo científico publicado en 2016

The interconnections between somatic and ovarian aging in murine models

artículo científico publicado en 2020

The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).

artículo científico publicado en 2012

The role of Ames dwarfism and calorie restriction on gut microbiota

scientific article published on 30 October 2019

The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice

artículo científico publicado en 2013

The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling.

artículo científico publicado en 2017

Thyroxine modifies the effects of growth hormone in Ames dwarf mice

artículo científico publicado en 2015

Tissue and serum microRNA profile of oral squamous cell carcinoma patients.

artículo científico publicado en 2018

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

artículo científico publicado en 2015

Unpredictable changes of selected miRNA in expression profile of HNSCC.

artículo científico publicado en 2015

Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice.

artículo científico publicado en 2012

hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer

artículo científico publicado en 2017

hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification

artículo científico publicado en 2018

hTERT promoter methylation status in peripheral blood leukocytes as a molecular marker of head and neck cancer progression

artículo científico publicado en 2018

miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes

artículo científico publicado en 2021

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