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2744. A Phase I Randomized, Observer-Blind, Controlled, Dose Escalation Trial of the Safety and Tolerability of a Single Intramuscular Dose of a PAL Adjuvant (Laboratory Code, FB-631) Co-administered with Seasonal TIV (2013–2014) to Healthy Adults ≥

artículo científico publicado en 2019

992. 2016–2017 Influenza Burden of Disease and End-of-Season Influenza Vaccine Effectiveness (VE) Estimates for Preventing Influenza-Related Hospitalization Among Canadian Adults: An Analysis From the Canadian Immunization Research Network (CIRN) S

article

A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age

artículo científico publicado en 2020

A Relationship Between Blood Levels of Otolin-1 and Vitamin D.

artículo científico publicado en 2018

A contributing role for anti-neuraminidase antibodies on immunity to pandemic H1N1 2009 influenza A virus

artículo científico publicado en 2011

A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B ⬇️

artículo científico publicado el 1 de mayo de 2003

A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults

artículo científico publicado en 2004

AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial ⬇️

artículo científico publicado el 19 de marzo de 2013

Age and frailty in COVID-19 vaccine development

artículo científico publicado en 2020

Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans ⬇️

artículo científico publicado el 3 de marzo de 2011

Age-related decline in interleukin 2 production in response to influenza vaccine

scientific article published on 01 June 1990

Ageing and respiratory infections: the airway of ageing

artículo científico

Antibody response to whole-virus and split-virus influenza vaccines in successful ageing

artículo científico publicado en 1993

Anticardiolipin antibodies in two elderly subpopulations

artículo científico publicado en 1995

Assessment of markers of the cell-mediated immune response after influenza virus infection in frail older adults.

artículo científico publicado en 1998

Better influenza vaccines for older people: what will it take?

artículo científico publicado en 2008

CMV and Immunosenescence: from basics to clinics

artículo científico publicado en 2012

COVID-19, frailty and long-term care: Implications for policy and practice

artículo científico publicado en 2020

Cell-Mediated Immune Response to Influenza Using Ex Vivo Stimulation and Assays of Cytokine and Granzyme B Responses

artículo científico publicado en 2015

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison

artículo científico publicado en 2017

Changes in CD45 isoform expression after influenza vaccination

artículo científico publicado en 1993

Changes in CD45 isoform expression vary according to the duration of T-cell memory after vaccination.

artículo científico publicado en 1995

Characterization of a granule-independent lytic mechanism used by CTL hybridomas.

artículo científico publicado en 1994

Chemokines are associated with delirium after cardiac surgery

artículo científico publicado en 2008

Clinical and immunologic predictors of influenza illness among vaccinated older adults

artículo científico publicado en 2010

Cochrane re-arranged: support for policies to vaccinate elderly people against influenza

artículo científico

Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults

artículo científico publicado en 2005

Comparison of the safety and immunogenicity of 2 respiratory syncytial virus (rsv) vaccines--nonadjuvanted vaccine or vaccine adjuvanted with alum--given concomitantly with influenza vaccine to high-risk elderly individuals

artículo científico publicado en 2008

Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research

artículo científico publicado en 2010

Correlates of protection: novel generations of influenza vaccines.

artículo científico publicado en 2008

Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model

artículo científico publicado en 2010

Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery

artículo científico publicado en 2015

Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.

artículo científico publicado en 2017

Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.

artículo científico publicado en 2018

ELISA and multiplex technologies for cytokine measurement in inflammation and aging research

artículo científico publicado en 2008

Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults

artículo científico publicado en 2004

Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD

artículo científico publicado en 2019

Efficacy and Safety of CVT-E002, a Proprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza-Vaccinated Community-Dwelling Adults: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial

artículo científico publicado en 2011

Efficacy and safety of inhaled zanamivir in the prevention of influenza in community-dwelling, high-risk adult and adolescent subjects: a 28-day, multicenter, randomized, double-blind, placebo-controlled trial

artículo científico publicado en 2007

Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial

scientific article published on 01 March 2006

Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults

artículo científico publicado en 2015

Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older

artículo científico publicado en 2016

Epidemiology of Influenza Viruses in Canada over the 2011–2012 to 2013–2014 Seasons: A Study from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN).

artículo científico publicado en 2017

Estimating influenza vaccine effectiveness: Evolution of methods to better understand effects of confounding in older adults

artículo científico publicado en 2017

Exploring clinically meaningful changes for the frailty index in a longitudinal cohort of hospitalized older patients

artículo científico publicado en 2020

Exploring the many facets of research in late-life issues

artículo científico publicado en 2014

Frailty Hinders Recovery From Acute Respiratory Illness in Older Adults

Frailty Hinders Recovery From Influenza and Acute Respiratory Illness in Older Adults

artículo científico publicado en 2020

Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination

scientific article published on 24 April 2020

Frailty and Interprofessional Collaboration

artículo científico

Frailty, Inflammation and Immunosenescence

artículo científico

GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults

artículo científico publicado en 2011

Genetic and antigenic typing of seasonal influenza virus breakthrough cases from a 2008-2009 vaccine efficacy trial

artículo científico publicado en 2013

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

artículo científico publicado en 2009

Granzyme B: a marker of risk for influenza in institutionalized older adults

artículo científico publicado en 2001

Helper and cytotoxic T lymphocyte responses to influenza vaccination in healthy compared to diabetic elderly

artículo científico publicado en 1996

Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease

artículo científico publicado en 2015

Herpes zoster: a common disease that can have a devastating impact on patients' quality of life

artículo científico publicado en 2010

Human granzymes: related but far apart

artículo científico

Humoral and cellular immune responses following vaccination with purified recombinant hemagglutinin from influenza A (H3N2) virus

artículo científico publicado en 1997

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.

scientific article published on 14 June 2016

IMMUNOGENOMIC RESPONSES TO VACCINATION IN AGING: INSIGHTS INTO IMMUNE RESILIENCE

article

Identifying Factors That Predict the Prescription of Non-vitamin K Antagonist Oral Anticoagulants in Older Individuals With Atrial Fibrillation

artículo científico publicado en 2019

Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a protocol for a scoping review.

artículo científico publicado en 2017

Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a scoping review

article

Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged ≥50 Years.

artículo científico publicado en 2018

Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.

artículo científico publicado en 2014

Immune response to influenza vaccination in institutionalized elderly: effect on different T-cell subsets

artículo científico publicado en 1998

Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age.

artículo científico publicado en 2011

Immunogenicity and reactogenicity of high- vs. standard-dose trivalent inactivated influenza vaccine in healthcare workers: a pilot randomized controlled trial

artículo científico publicado en 2018

Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis

artículo científico publicado en 2016

Immunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults

artículo científico

Immunosenescence and influenza vaccine efficacy

artículo científico publicado en 2009

Immunosenescence: Influenza vaccination and the elderly

artículo científico

Immunosenescence: what does it mean to health outcomes in older adults?

artículo científico publicado en 2009

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.

artículo científico publicado en 2017

Impact of Antivirals in the Prevention of Serious Outcomes Associated with Influenza in Hospitalized Canadian Adults: A Pooled Analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN).

artículo científico publicado en 2017

Impact of Prior Season Influenza Vaccination on Seasonal Influenza Vaccine Effectiveness: An Analysis over Four Consecutive Seasons from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN).

artículo científico publicado en 2017

Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner.

artículo científico publicado en 2010

Influence of Obesity on Pneumococcus Infection Risk in the Elderly

article by Daniela Frasca & Janet E McElhaney published 2019 in Frontiers in Endocrinology

Influenza Infection in the Elderly

Influenza Vaccination Blunts the Inflammatory Response in Patients Undergoing Cardiopulmonary Bypass

artículo científico publicado en 2020

Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications

article

Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults

scientific article published on 09 April 2020

Influenza burden in frail elderly

artículo científico publicado en 2018

Influenza control in the 21st century: Optimizing protection of older adults

artículo científico publicado en 2009

Influenza surveillance case definitions miss a substantial proportion of older adults hospitalized with laboratory-confirmed influenza: A report from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) Network

artículo científico publicado en 2020

Influenza symptoms and their impact on elderly adults: randomised trial of AS03-adjuvanted or non-adjuvanted inactivated trivalent seasonal influenza vaccines

artículo científico publicado en 2014

Influenza vaccination in the elderly: seeking new correlates of protection and improved vaccines

artículo científico publicado en 2008

Influenza vaccine effectiveness against influenza-related hospitalization during a season with mixed outbreaks of four influenza viruses: a test-negative case-control study in adults in Canada

artículo científico publicado en 2017

Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Seriou

artículo científico publicado en 2018

Influenza vaccine responses in older adults

artículo científico publicado en 2010

Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage

artículo científico publicado en 2017

Influenza vaccines provide diminished protection but are cost-saving in older adults.

artículo científico publicado en 2010

Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.

artículo científico publicado en 2011

Influenza: a preventable lethal disease

artículo científico publicado en 2002

Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population.

artículo científico publicado en 2005

Interim estimates of 2013/14 influenza clinical severity and vaccine effectiveness in the prevention of laboratory-confirmed influenza-related hospitalisation, Canada, February 2014.

artículo científico publicado en 2014

Interim estimates of 2014/15 influenza vaccine effectiveness in preventing laboratory-confirmed influenza-related hospitalisation from the Serious Outcomes Surveillance Network of the Canadian Immunization Research Network, January 2015.

artículo científico publicado en 2015

Knowledge, attitudes, beliefs and behaviours of older adults about pneumococcal immunization, a Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) investigation

artículo científico publicado en 2014

Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly

artículo científico publicado en 2014

Liposomal influenza vaccine: a viewpoint by Janet E. McElhaney

artículo científico publicado en 1999

Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes

artículo científico publicado en 2007

MECHANISMS OF PROTECTION AGAINST HERPES ZOSTER AND POST-HERPETIC NEURALGIA THROUGH VACCINATION

article by Janet E McElhaney published 30 June 2017 in Innovation in Aging

Medical conditions at enrollment do not impact efficacy and safety of the adjuvanted recombinant zoster vaccine: a pooled post-hoc analysis of two parallel randomized trials

scientific article published on 28 June 2019

Mise à jour sur la vaccination contre l’herpès zoster: Guide à l’intention des médecins de famille

Moderate exercise improves antibody response to influenza immunization in older adults

artículo científico publicado en 2004

Mood and cytokine response to influenza virus in older adults

artículo científico publicado en 2004

NEW INSIGHTS INTO IMMUNOLOGIC MECHANISMS OF PROTECTION THROUGH VACCINATION IN OLDER ADULTS

article by Janet E McElhaney et al published 30 June 2017 in Innovation in Aging

No evidence of a link between influenza vaccines and Guillain–Barre syndrome–associated antiganglioside antibodies ⬇️

artículo científico publicado el 29 de septiembre de 2011

Nutrition, exercise, and influenza vaccination

artículo científico publicado en 2002

Overcoming the challenges of immunosenescence in the prevention of acute respiratory illness in older people

artículo científico publicado en 2003

Persistent Functional Decline Following Hospitalization with Influenza or Acute Respiratory Illness

scientific article published on 08 December 2020

Persistent pain in the elderly ⬇️

artículo científico publicado el 1 de enero de 2003

Perspectives on metanarrative as a way of factoring complexity into health services: research synthesis for transforming seniors’ care in Canada

article

Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence

artículo científico publicado en 2019

Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes

artículo científico publicado en 2015

Prevalence of selected autoantibodies in different elderly subpopulations

artículo científico publicado en 1994

Prevalence of seroprotection against the pandemic (H1N1) virus after the 2009 pandemic

artículo científico publicado en 2010

Prevention of herpes zoster and its painful and debilitating complications

artículo científico publicado en 2007

Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response

artículo científico publicado en 2009

Quality of Life Impact of an Adjuvanted Recombinant Zoster Vaccine in Adults Aged 50 Years and Older

artículo científico publicado en 2019

ROLE OF IMMUNOSENESCENCE, FRAILTY, CMV AND VACCINE DOSE IN IMMUNE RESPONSES TO INFLUENZA VACCINATION

artículo científico publicado en 2017

Recent advances in influenza vaccines

artículo científico publicado en 2020

Recruitment and retention of healthy and high-risk older adults for a multiyear influenza vaccination study.

artículo científico publicado en 2014

Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus

scientific article published on 31 January 2020

Reply: Letter to the editor, Cochrane rearranged.

artículo científico publicado en 2014

Report of the ad-hoc consultation on aging and immunization for a future WHO research agenda on life-course immunization ⬇️

artículo científico publicado el 24 de julio de 2012

Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network

artículo científico publicado en 2017

Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness

artículo científico publicado en 2014

Responses to influenza vaccination in different T-cell subsets: a comparison of healthy young and older adults

artículo científico publicado en 1998

Results of a Safety Pooled Analysis of an Adjuvanted Herpes Zoster Subunit Vaccine in More than 14,500 Participants Aged 50 Years or Older.

artículo científico publicado en 2017

Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials

scientific article published on 29 March 2019

Safety, immunogenicity, and tolerability of three influenza vaccines in older adults: results of a randomized, controlled comparison

artículo científico publicado en 2013

Split-virus influenza vaccines: do they provide adequate immunity in the elderly?

artículo científico publicado en 1994

Standardization and validation of assays determining cellular immune responses against influenza

article

Standing orders for influenza vaccination increased vaccination rates in inpatient settings compared with community rates

artículo científico publicado en 2000

Study protocol for a hospital-to-home transitional care intervention for older adults with multiple chronic conditions and depressive symptoms: a pragmatic effectiveness-implementation trial

artículo científico publicado en 2020

T cell responses are better correlates of vaccine protection in the elderly

artículo científico publicado en 2006

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

artículo científico publicado en 2016

T-Cell Phenotypes Predictive of Frailty and Mortality in Elderly Nursing Home Residents

artículo científico publicado en 2016

Telomere length and chronic obstructive pulmonary disease: evidence of accelerated aging

artículo científico publicado en 2009

Test-Negative Design: The Importance of Laboratory-Confirmed Illness in Estimating the Effectiveness of Influenza Vaccine in Older Adults.

artículo científico publicado en 2017

The Canadian Frailty Priority Setting Partnership: Research Priorities for Older Adults Living with Frailty

artículo científico publicado en 2019

The Effect of Influenza Vaccination on IL2 Production in Healthy Elderly: Implications for Current Vaccination Practices ⬇️

artículo científico publicado el 1 de enero de 1992

The Impact of Prior Season Vaccination on Subsequent Influenza Vaccine Effectiveness to Prevent Influenza-related Hospitalizations Over 4 Influenza Seasons in Canada

artículo científico publicado en 2019

The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People

article

The Prevention of Infections in Older Adults: Vaccination

artículo científico publicado en 2019

The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America

artículo científico publicado en 2008

The cell-mediated cytotoxic response to influenza vaccination using an assay for granzyme B activity

scientific article published on 01 March 1996

The comparative efficacy and safety of herpes zoster vaccines: A network meta-analysis

scientific article published on 11 April 2019

The confounded effects of age and exposure history in response to influenza vaccination

artículo científico publicado en 2015

The disease burden of influenza beyond respiratory illness

artículo científico publicado en 2020

The immune response to influenza in older humans: beyond immune senescence

artículo científico publicado en 2020

The impact of CMV infection on survival in older humans

artículo científico

The impact of varicella zoster virus: chronic pain

artículo científico publicado en 2010

The role of inflammation in age-related disease

artículo científico publicado en 2013

The unmet need in the elderly: designing new influenza vaccines for older adults

artículo científico publicado en 2005

The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

artículo científico publicado en 2012

Third European Influenza Summit: organized by the European Scientific Working group on Influenza (ESWI).

artículo científico publicado en 2013

Understanding transitional care programmes for older adults who experience delayed discharge: a scoping review protocol

scientific article published on 16 December 2019

Update on herpes zoster vaccination: a family practitioner's guide ⬇️

artículo científico publicado el 1 de octubre de 2011

Vaccination programs for older adults in an era of demographic change.

artículo científico publicado en 2018

Vaccine-related determinants of the interleukin-2 response to influenza vaccination in healthy young and elderly adults

artículo científico publicado en 1995

Vaccines for Improved Cellular Immunity to Influenza.

artículo científico publicado en 2018

Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults

artículo científico publicado en 2019

Zoster Vaccination in Older Adults: Efficacy and Public Health Implications

artículo científico publicado en 2019

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