Lista de obras -

A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9

scientific article published on 01 November 2007

A size filtration approach to purify low affinity complexes for crystallization

artículo científico publicado en 2007

A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism

artículo científico publicado en 2008

An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

artículo científico publicado en 2015

Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation

artículo científico publicado en 2010

CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.

artículo científico publicado en 2016

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

artículo científico publicado en 2005

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1

artículo científico publicado en 2003

Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).

artículo científico publicado en 2016

Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers

artículo científico publicado en 2012

Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

artículo científico publicado en 2014

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Recepto

scientific article published on 27 November 2019

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations

artículo científico publicado en 2018

Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state

artículo científico publicado en 2008

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding

artículo científico publicado en 2008

Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor

scientific article published on 14 May 2019

Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases

artículo científico publicado en 2008

Giantin interacts with both the small GTPase Rab6 and Rab1.

artículo científico publicado en 2007

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex

artículo científico publicado en 2002

NMR structure of bacterial ribosomal protein l20: implications for ribosome assembly and translational control

artículo científico publicado en 2002

NMR structure of the ribosomal protein L23 from Thermus thermophilus

artículo científico publicado en 2003

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

artículo científico publicado en 2006

Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex

artículo científico publicado en 2006

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

artículo científico publicado en 2007

Rab GTPases at a glance

scientific article published on 01 November 2007

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases

artículo científico publicado en 2002

Sec2 is a Highly Efficient Exchange Factor for the Rab Protein Sec4

scientific article published on 03 November 2006

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

artículo científico publicado en 2015

Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule

artículo científico publicado en 2014

Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coli

artículo científico publicado en 2002

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

artículo científico publicado en 2003

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

artículo científico publicado en 2003

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

artículo científico publicado en 2006

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

artículo científico publicado en 2004

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution

artículo científico publicado en 2005

Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions

artículo científico publicado en 2014

The PX-BAR membrane-remodeling unit of sorting nexin 9

artículo científico publicado en 2007

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation

artículo científico publicado en 2008

The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold

artículo científico publicado en 2002

The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1

artículo científico publicado en 2013

Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab

scientific article published on 26 November 2019

[Developability assessment with case studies highlighting the decision taking]

scientific article published on 01 December 2019

Lista de obras de

A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9

A size filtration approach to purify low affinity complexes for crystallization

A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism

An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation

CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1

Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).

Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers

Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Recepto

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations

Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding

Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor

Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases

Giantin interacts with both the small GTPase Rab6 and Rab1.

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex

NMR structure of bacterial ribosomal protein l20: implications for ribosome assembly and translational control

NMR structure of the ribosomal protein L23 from Thermus thermophilus

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

Rab GTPases at a glance

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases

Sec2 is a Highly Efficient Exchange Factor for the Rab Protein Sec4

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule

Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coli

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution

Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions

The PX-BAR membrane-remodeling unit of sorting nexin 9

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation

The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold

The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1

Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab

[Developability assessment with case studies highlighting the decision taking]