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967. Inhibition of Host Neuraminidase Increases Susceptibility to Invasive Pulmonary Aspergillosis

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

artículo científico publicado en 2016

A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans

artículo científico publicado en 2019

A guiding map for inflammation

artículo científico publicado en 2017

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist

artículo científico publicado en 2014

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

scientific article published on 01 June 2019

An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism

artículo científico publicado en 2014

An exaggerated monocyte-derived cytokine response to Candida hyphae in patients with recurrent vulvovaginal candidiasis

scientific article published on 23 July 2020

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility

artículo científico publicado en 2017

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

artículo científico publicado en 2020

Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity.

artículo científico publicado en 2009

Antifungal innate immunity: recognition and inflammatory networks

artículo científico publicado en 2014

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

artículo científico publicado en 2015

Aspergillus fumigatus morphology and dynamic host interactions

artículo científico publicado en 2017

Aspergillus fumigatus-induced IL-22 is not restricted to a specific Th cell subset and is dependent on complement receptor 3.

artículo científico publicado en 2013

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

scientific article published in 2021

Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes

artículo científico publicado en 2017

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer

artículo científico publicado en 2014

Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β)

artículo científico publicado en 2013

Basic Genetics and Immunology of Candida Infections

artículo científico publicado en 2016

Biology of IL-36 cytokines and their role in disease

artículo científico publicado en 2013

Blocking IL-1 to prevent respiratory failure in COVID-19

artículo científico publicado en 2020

Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism

artículo científico publicado en 2010

Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent.

artículo científico publicado en 2015

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

artículo científico publicado en 2016

Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans

artículo científico publicado en 2009

CBLB ubiquitin ligase: a major regulator of antifungal immunity

artículo científico publicado en 2016

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

artículo científico publicado en 2020

Candida albicans dampens host defense by downregulating IL-17 production.

artículo científico publicado en 2010

Candida albicans morphogenesis and host defence: discriminating invasion from colonization. ⬇️

artículo científico

Caspase-1, but not ASC or NLRP3 inflammasome components, mediates IL-1beta activation and antifungal defense in disseminated candidiasis

scientific article published in 2009

Combination of biomarkers for the discrimination between bacterial and viral lower respiratory tract infections ⬇️

artículo científico publicado el 13 de agosto de 2012

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

artículo científico publicado en 2020

Compartmentalized Cytokine Responses in Hidradenitis Suppurativa

artículo científico publicado en 2015

Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling

scientific article published on July 2013

Cytokine production assays reveal discriminatory immune defects in adults with recurrent infections and noninfectious inflammation

artículo científico publicado en 2014

Defects of pattern recognition: primary immunodeficiencies of the innate immune system

artículo científico publicado en 2011

Deficient Candida-specific T-helper 17 response during sepsis

artículo científico publicado en 2012

Deficient autophagy unravels the ROS paradox in chronic granulomatous disease

artículo científico publicado en 2014

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo

artículo científico publicado en 2017

Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis.

artículo científico publicado en 2017

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

artículo científico publicado en 2008

Diversity: A Hallmark of Monocyte Society ⬇️

artículo científico publicado el 24 de septiembre de 2010

Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

artículo científico publicado en 2021

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

scientific article published on 02 September 2020

Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

artículo científico publicado en 2010

Erratum: IL-1 family nomenclature

scholarly article by Charles A. Dinarello et al published March 2011 in Nature Immunology

Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis

artículo científico publicado en 2012

FAVORABLE ANAKINRA RESPONSES IN SEVERE COVID-19 PATIENTS WITH SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

artículo científico publicado en 2020

Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations.

artículo científico publicado en 2017

Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

artículo científico publicado en 2015

Genetic susceptibility to Candida infections

artículo científico publicado en 2013

Genome-Wide Association Study Reveals CLEC7A and PROM1 as Potential Regulators of Paracoccidioides brasiliensis-Induction of Cytokine Production in Peripheral Blood Mononuclear Cells

scientific article published in 2023

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

artículo científico publicado en 2016

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

artículo científico publicado en 2016

Host-microbe interactions: innate pattern recognition of fungal pathogens

artículo científico publicado en 2008

Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.

artículo científico publicado en 2015

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease

artículo científico publicado en 2020

IL-1 family nomenclature

artículo científico publicado en 2010

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

artículo científico publicado en 2016

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

scientific article published on 18 February 2014

IL-1-8 IL-1β and the development of Th17 responses

artículo científico publicado en 2010

IL-18 Serum Concentration Is Markedly Elevated in Acute EBV Infection and Can Serve as a Marker for Disease Severity ⬇️

artículo científico publicado el 11 de junio de 2012

IL-1beta processing in host defense: beyond the inflammasomes

artículo científico publicado en 2010

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

artículo científico publicado en 2016

IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis

artículo científico publicado en 2014

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

artículo científico publicado en 2012

IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation

artículo científico publicado en 2014

Immune defects in patients with pulmonary <i>Mycobacterium abscessus</i> disease without cystic fibrosis

artículo científico publicado en 2020

Immune defence against Candida fungal infections

artículo científico

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

artículo científico publicado en 2014

Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy

artículo científico publicado en 2016

Immunotherapeutic approaches to treatment of fungal diseases.

artículo científico publicado en 2017

Immunotherapy: a potential adjunctive treatment for fungal infection

artículo científico publicado en 2014

In-host adaptation and acquired triazole resistance in Aspergillus fumigatus: a dilemma for clinical management

artículo científico publicado en 2016

Inflammasome activation and IL-1β and IL-18 processing during infection

artículo científico publicado en 2011

Inflammasome is a central player in the induction of obesity and insulin resistance

artículo científico publicado en 2011

Inflammasome-independent modulation of cytokine response by autophagy in human cells

artículo científico publicado en 2011

Inflammasome-independent regulation of IL-1-family cytokines

artículo científico

Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis

artículo científico publicado en 2010

Influenza-Associated Aspergillosis in Critically Ill Patients.

artículo científico publicado en 2017

Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia

artículo científico publicado en 2011

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

artículo científico publicado en 2014

Invasive Aspergillus Tracheobronchitis Emerging as Highly Lethal Complication of Severe Influenza

artículo científico publicado en 2020

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

scientific article published on 27 April 2020

LC3-associated phagocytosis: a crucial mechanism for antifungal host defence against Aspergillus fumigatus

artículo científico publicado en 2016

Low interleukin-17A production in response to fungal pathogens in patients with chronic granulomatous disease

artículo científico publicado en 2011

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

artículo científico publicado en 2018

Mimicking Behcet's disease: GM-CSF gain of function mutation in a family suffering from a Behcet's disease-like disorder marked by extreme pathergy

artículo científico publicado en 2020

Modulation of inflammation by autophagy: Consequences for human disease

artículo científico publicado en 2016

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

artículo científico publicado en 2022

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.

artículo científico publicado en 2012

Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1.

artículo científico publicado en 2010

Neutrophil-mediated inhibition of proinflammatory cytokine responses

artículo científico publicado en 2012

New Insights in the Immunobiology of IL-1 Family Members

artículo científico

Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy

artículo científico publicado en 2010

Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity

scientific article published in 2023

Pathogenesis of invasive candidiasis

scientific article published on October 2010

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

artículo científico publicado en 2015

Pattern recognition receptors and their role in invasive aspergillosis ⬇️

artículo científico publicado el 1 de diciembre de 2012

Personalized medicine in influenza: a bridge too far or the near future?

artículo científico publicado en 2017

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

scientific article published on 08 May 2020

Primary immunodeficiencies in cytosolic pattern-recognition receptor pathways: Toward host-directed treatment strategies

artículo científico publicado en 2020

Primary immunodeficiencies of pattern recognition receptors ⬇️

artículo científico publicado el 12 de septiembre de 2012

Progressive multifocal leukoencephalopathy in an immunocompetent patient

artículo científico publicado en 2016

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37.

artículo científico publicado en 2014

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

artículo científico publicado en 2010

Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide

artículo científico publicado en 2009

Reduced concentrations of the B cell cytokine Interleukin 38 are associated with cardiovascular disease risk in overweight subjects

artículo científico publicado en 2020

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor

artículo científico publicado en 2016

Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion

artículo científico publicado en 2020

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

artículo científico publicado en 2017

Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

artículo científico publicado en 2017

Role of TLR1 and TLR6 in the host defense against disseminated candidiasis

artículo científico publicado en 2007

Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease

artículo científico publicado en 2011

STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis

artículo científico publicado en 2011

STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

artículo científico publicado en 2011

STAT3 phosphorylation mediates the stimulatory effects of interferon alpha on B cell differentiation and activation in SLE

scientific article published on 01 March 2020

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

artículo científico publicado en 2020

Severe Candida spp. infections: new insights into natural immunity

artículo científico publicado en 2010

Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses

artículo científico publicado en 2013

T-cell Subsets and Antifungal Host Defenses ⬇️

artículo científico publicado el 30 de septiembre de 2010

TREML4 adds fuel to the TLR7 fire

artículo científico publicado en 2015

Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis

artículo científico publicado en 2015

Th17 responses and host defense against microorganisms: an overview

scientific article published on December 2009

The BNT162b2 mRNA Vaccine Against SARS-CoV-2 Reprograms Both Adaptive and Innate Immune Responses

scientific article published in 2021

The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2.

artículo científico publicado en 2010

The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses

artículo científico publicado en 2013

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

artículo científico publicado en 2015

The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis

artículo científico publicado en 2016

The classical CD14⁺⁺ CD16⁻ monocytes, but not the patrolling CD14⁺ CD16⁺ monocytes, promote Th17 responses to Candida albicans

artículo científico publicado en 2011

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

artículo científico publicado en 2011

The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

artículo científico publicado en 2014

The effects of in vivo B-cell depleting therapy on ex-vivo cytokine production

artículo científico publicado en 2013

The effects of signal transducer and activator of transcription three mutations on human platelets.

artículo científico publicado en 2017

The immunopathology of sepsis and potential therapeutic targets

artículo científico publicado en 2017

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.

scientific article published on 04 July 2011

The interplay between inflammasome activation and antifungal host defense

artículo científico

The macrophage mannose receptor induces IL-17 in response to Candida albicans.

artículo científico publicado en 2009

The potential impact of the pulmonary microbiome on immunopathogenesis of Aspergillus-related lung disease

artículo científico publicado en 2014

The role of interleukin-1 family members in the host defence against Aspergillus fumigatus

artículo científico publicado en 2014

The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis ⬇️

artículo científico publicado el 1 de enero de 2002

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics

artículo científico publicado en 2017

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

scientific article published on 04 May 2020

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

artículo científico publicado en 2020

Treatment options for chronic mucocutaneous candidiasis

artículo científico publicado en 2016

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects.

artículo científico publicado en 2014

Understanding human immune function using the resources from the Human Functional Genomics Project

artículo científico publicado en 2016

Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway

artículo científico publicado en 2017

When the Fight against Fungi Goes Wrong

artículo científico publicado en 2016

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

artículo científico publicado en 2014

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