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(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons.

artículo científico publicado en 2007

5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

artículo científico publicado en 2002

A novel combined biomarker including plasma carotenoids, vitamin C, and ferric reducing antioxidant power is more strongly associated with fruit and vegetable intake than the individual components

artículo científico publicado en 2014

A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats

artículo científico publicado en 2013

Absorption and metabolism of olive oil secoiridoids in the small intestine

artículo científico publicado en 2011

Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats

artículo científico publicado en 2006

Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury

artículo científico publicado en 2006

Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons.

artículo científico publicado en 2007

Acute Effects of Hibiscus Sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers of Insulin Resistance and Inflammation in Humans

scholarly article by Salisu M Abubakar et al published 5 February 2019 in Nutrients

Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants

artículo científico publicado en 2005

Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing

article by David Vauzour et al published 31 July 2021 in Antioxidants (Basel, Switzerland)

Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union.

artículo científico

Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity

scientific article published on 13 March 2015

Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk).

artículo científico publicado en 2015

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

artículo científico publicado en 2010

Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

artículo científico publicado en 2007

Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats

artículo científico publicado en 2012

Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats

artículo científico publicado en 2012

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

artículo científico publicado en 2008

Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity

artículo científico publicado en 2010

Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity

artículo científico publicado en 2004

Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury

artículo científico publicado en 2007

Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults

artículo científico publicado en 2015

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

artículo científico publicado en 2015

Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studies

artículo científico publicado en 2010

Composition and content of phenolic acids and avenanthramides in commercial oat products: Are oats an important polyphenol source for consumers?

scientific article published on 04 July 2019

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species

artículo científico publicado el 1 de noviembre de 1998

Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients

artículo científico

Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men.

artículo científico publicado en 2008

Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor

Dietary flavonoids as potential neuroprotectants

artículo científico publicado en 2002

Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.

artículo científico publicado en 2013

Distribution of [3H]trans-resveratrol in rat tissues following oral administration

artículo científico publicado en 2006

Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?

artículo científico publicado en 2008

Effect of cultivar type and ripening on the polyphenol content of date palm fruit.

artículo científico publicado en 2013

Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts

scientific article published on 29 August 2017

Effects of pelargonidin-3-O-glucoside and its metabolites on lipopolysaccharide-stimulated cytokine production by THP-1 monocytes and macrophages

artículo científico publicado en 2018

Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts

artículo científico publicado el 15 de octubre de 2003

Excretion of Avenanthramides, Phenolic Acids and their Major Metabolites Following Intake of Oat Bran.

artículo científico publicado en 2017

Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans.

artículo científico publicado en 2015

Flavanol metabolites reduce monocyte adhesion to endothelial cells through modulation of expression of genes via p38-MAPK and p65-Nf-kB pathways.

artículo científico publicado en 2014

Flavanol monomer-induced changes to the human faecal microflora.

artículo científico publicado en 2007

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study

artículo científico publicado en 2017

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study - CORRIGENDUM.

artículo científico publicado en 2017

Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments

artículo científico publicado en 2013

Flavonoid intake in European adults (18 to 64 years).

artículo científico publicado en 2015

Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease--FLAVURS: a randomized controlled trial

artículo científico publicado en 2014

Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males

scientific article published on 18 August 2015

Flavonoids and brain health: multiple effects underpinned by common mechanisms

artículo científico publicado en 2009

Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects.

artículo científico publicado en 2009

Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies

artículo científico publicado en 2009

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

artículo científico

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

artículo científico publicado el 17 de septiembre de 2011

Flavonoids: antioxidants or signalling molecules?

artículo científico publicado en 2004

Flavonoids: modulators of brain function?

artículo científico publicado en 2008

Food for thought

artículo científico publicado en 2009

Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance

artículo científico publicado en 2008

Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers

artículo científico publicado en 2016

Glial metabolism of quercetin reduces its neurotoxic potential

artículo científico publicado en 2008

Grape seed polyphenol extract and cognitive function in healthy young adults: a randomised, placebo-controlled, parallel-groups acute-on-chronic trial

scientific article published on 16 January 2020

Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

artículo científico publicado en 2018

High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials.

artículo científico publicado en 2016

Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.

artículo científico publicado en 2009

Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: a randomized controlled trial

artículo científico publicado en 2018

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial

artículo científico publicado en 2015

Impact of cooking, proving, and baking on the (poly)phenol content of wild blueberry

artículo científico publicado en 2013

Impact of palm date consumption on microbiota growth and large intestinal health: a randomised, controlled, cross-over, human intervention study.

artículo científico publicado en 2015

Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols

artículo científico publicado en 2014

Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial

artículo científico publicado en 2012

In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth.

artículo científico publicado en 2015

Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial

artículo científico publicado en 2020

Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?

artículo científico publicado en 2012

Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects.

artículo científico

Influence of sugar type on the bioavailability of cocoa flavanols

artículo científico publicado en 2012

Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons.

artículo científico publicado en 2018

Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway.

artículo científico publicado en 2007

Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects.

artículo científico publicado en 2007

Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols

artículo científico publicado en 2007

Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs

artículo científico publicado en 2012

Interactions between cocoa flavanols and inorganic nitrate: additive effects on endothelial function at achievable dietary amounts

artículo científico publicado en 2014

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.

artículo científico publicado en 2003

Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol

artículo científico publicado en 2010

Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo

artículo científico publicado en 2008

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

artículo científico publicado en 2002

Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials

artículo científico publicado en 2016

Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth

artículo científico publicado en 2012

Metabolism of Tea Flavonoids in the Gastrointestinal Tract

artículo científico publicado el 1 de octubre de 2003

Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

artículo científico publicado en 2009

Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.

artículo científico publicado en 2003

Neuroinflammation: modulation by flavonoids and mechanisms of action

artículo científico publicado en 2011

Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

artículo científico publicado en 2008

Nutrients and brain health: an overview

artículo científico publicado en 2009

Nutrition and the ageing brain: Moving towards clinical applications

artículo científico publicado en 2020

Nutrition for the ageing brain: Towards evidence for an optimal diet

artículo científico publicado en 2016

Oat bran, but not its isolated bioactive β-glucans or polyphenols, have a bifidogenic effect in an in vitro fermentation model of the gut microbiota

scientific article published on 28 January 2019

Olive Oil Phenolics Prevent Oxysterol-Induced Proinflammatory Cytokine Secretion and Reactive Oxygen Species Production in Human Peripheral Blood Mononuclear Cells, Through Modulation of p38 and JNK Pathways

artículo científico publicado en 2017

Olive Polyphenols and the Metabolic Syndrome.

artículo científico publicado en 2017

Orange pomace fibre increases a composite scoring of subjective ratings of hunger and fullness in healthy adults

artículo científico publicado en 2016

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Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols

artículo científico publicado en 2008

Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation

artículo científico publicado en 2013

Platelet-mediated metabolism of the common dietary flavonoid, quercetin

artículo científico publicado en 2010

Polyphenols

article

Polyphenols and human health: prevention of disease and mechanisms of action

artículo científico publicado en 2010

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions

artículo científico publicado en 2017

Potential Neuroprotective Actions of Dietary Flavonoids

Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study.

artículo científico publicado en 2010

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine.

artículo científico publicado en 2013

Procyanidin, anthocyanin, and chlorogenic acid contents of highbush and lowbush blueberries.

artículo científico publicado en 2012

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs

artículo científico publicado en 2010

Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations

artículo científico publicado en 2012

Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial

artículo científico publicado en 2015

Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase

artículo científico publicado en 2008

Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes

artículo científico publicado en 2010

Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures.

artículo científico publicado en 2019

The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function

article

The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

artículo científico publicado en 2009

The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans

artículo científico publicado en 2003

The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial

artículo científico publicado en 2015

The effect of processing on chlorogenic acid content of commercially available coffee.

artículo científico publicado en 2013

The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults

artículo científico publicado en 2017

The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation

scientific article published on 01 June 2006

The genotypic variation of the antioxidant potential of different tomato varieties

artículo científico publicado en 2005

The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet

artículo científico publicado en 2015

The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation.

artículo científico publicado en 2014

The impact of flavonoids on memory: physiological and molecular considerations

scientific article published on 20 January 2009

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

artículo científico publicado en 2009

The impact of fruit flavonoids on memory and cognition

artículo científico publicado el 1 de octubre de 2010

The interactions of flavonoids within neuronal signalling pathways

artículo científico publicado en 2007

The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.

artículo científico publicado en 2006

The intracellular metabolism of isoflavones in endothelial cells

artículo científico publicado en 2014

The mechanisms of action of flavonoids in the brain: Direct versus indirect effects.

artículo científico

The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives

artículo científico publicado en 2016

The neuroprotective potential of flavonoids: a multiplicity of effects

artículo científico publicado en 2008

The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling

artículo científico publicado en 2014

The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways

artículo científico publicado en 2007

The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.

artículo científico publicado en 2005

Thioflavones as novel neuroprotective agents

artículo científico publicado en 2016

Uptake and metabolism of (-)-epicatechin in endothelial cells

artículo científico publicado en 2014

Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage.

artículo científico publicado en 2004

c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis

artículo científico publicado en 2003