Lista de obras -

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

artículo científico publicado en 2018

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

artículo científico publicado en 2008

A comprehensive transcriptional portrait of human cancer cell lines

artículo científico publicado en 2014

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

artículo científico publicado en 2006

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

artículo científico publicado en 2006

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation

artículo científico publicado en 2013

Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

artículo científico publicado en 2009

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

artículo científico publicado en 2005

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

artículo científico publicado en 2008

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.

artículo científico publicado en 2015

Bioelectrical impedance vector analysis, phase-angle assessment and relationship with malnutrition risk in a cohort of frail older hospital patients in the United Kingdom

artículo científico publicado en 2014

Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.

artículo científico publicado en 2008

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes

artículo científico publicado en 2014

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.

artículo científico publicado en 2011

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

artículo científico publicado en 2012

Diverse somatic mutation patterns and pathway alterations in human cancers

artículo científico publicado en 2010

EGFR signals to mTOR through PKC and independently of Akt in glioma

artículo científico publicado en 2009

ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer

artículo científico publicado en 2019

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.

artículo científico publicado en 2012

Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes

artículo científico publicado en 2006

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

artículo científico publicado en 2005

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines

artículo científico publicado en 2012

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.

artículo científico publicado en 2017

Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism

artículo científico publicado en 2005

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

artículo científico publicado en 2017

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

artículo científico publicado en 2007

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

artículo científico publicado en 2005

New insights into PTEN.

artículo científico publicado en 2007

Oncogenic activating mutations are associated with local copy gain

artículo científico publicado en 2009

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

artículo científico publicado en 2008

PTEN in brain tumors

scientific article published on April 2008

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

artículo científico publicado en 2016

Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma

artículo científico publicado en 2008

Phosphatase and tensin homologue growth suppression without phosphatase

artículo científico publicado en 2005

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

artículo científico publicado en 2010

Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

artículo científico publicado en 2017

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

artículo científico publicado en 2006

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

artículo científico publicado en 2016

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

artículo científico publicado en 2012

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

artículo científico publicado en 2004

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents ⬇️

artículo científico publicado el 1 de noviembre de 2003

The phosphoinositide 3-kinase pathway and cancer

artículo científico publicado en 2005

Translational deregulation in PDK-1-/- embryonic stem cells

artículo científico publicado en 2005

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

artículo científico publicado en 2007

ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction

artículo científico publicado en 2005

Zinc finger nucleases as tools to understand and treat human diseases

artículo científico publicado en 2010

mTOR-independent translational control of the extrinsic cell death pathway by RalA.

artículo científico publicado en 2006

Lista de obras de

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

A comprehensive transcriptional portrait of human cancer cell lines

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation

Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.

Bioelectrical impedance vector analysis, phase-angle assessment and relationship with malnutrition risk in a cohort of frail older hospital patients in the United Kingdom

Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

Diverse somatic mutation patterns and pathway alterations in human cancers

EGFR signals to mTOR through PKC and independently of Akt in glioma

ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.

Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.

Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

New insights into PTEN.

Oncogenic activating mutations are associated with local copy gain

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

PTEN in brain tumors

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma

Phosphatase and tensin homologue growth suppression without phosphatase

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents ⬇️

The phosphoinositide 3-kinase pathway and cancer

Translational deregulation in PDK-1-/- embryonic stem cells

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction

Zinc finger nucleases as tools to understand and treat human diseases

mTOR-independent translational control of the extrinsic cell death pathway by RalA.