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3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

artículo científico publicado en 2016

3D human microvessel-on-a-chip model for studying monocyte-to-endothelium adhesion under flow - application in systems toxicology

scientific article published on 22 August 2019

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

artículo científico publicado en 2014

A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke

scientific article published on 24 January 2020

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product

artículo científico publicado en 2015

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clin

artículo científico publicado en 2018

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology asses

artículo científico publicado en 2018

A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2)

article

A Systems Toxicology Approach to Investigating the Cardiovascular Effects of Cigarette Smoke and Environmental Pollutants in ApoE-Deficient Mice

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

artículo científico publicado en 2011

A crowd-sourcing approach for the construction of species-specific cell signaling networks

artículo científico publicado en 2014

A framework for in vitro systems toxicology assessment of e-liquids

artículo científico publicado en 2016

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

artículo científico publicado en 2019

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

scientific article published on 01 December 2018

A meta-analysis of microRNAs expressed in human aerodigestive epithelial cultures and their role as potential biomarkers of exposure response to nicotine-containing products

scientific article published on 12 September 2020

A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue

artículo científico publicado en 2013

A network-based approach to quantifying the impact of biologically active substances

artículo científico publicado en 2011

A new fluorescence-based method for characterizing in vitro aerosol exposure systems

artículo científico publicado en 2016

A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

artículo científico publicado en 2015

A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes

scientific article published on 12 February 2019

A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro

artículo científico publicado en 2015

A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

artículo científico publicado en 2016

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.

artículo científico publicado en 2014

Aerosol Flow in the Vitrocell 24/48 Exposure System: Flow Mixing and Aerosol Coalescence

Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke

artículo científico publicado en 2017

Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes

artículo científico publicado en 2015

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

artículo científico publicado en 2016

Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects

artículo científico publicado en 2015

Alternatives to Animal Use in Risk Assessment of Mixtures

artículo científico publicado en 2020

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

artículo científico publicado en 2015

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/−Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

artículo científico publicado en 2016

An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes

artículo científico publicado en 2020

An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors

artículo científico publicado en 2019

Analysis of chemical deposits on tooth enamel exposed to total particulate matter from cigarette smoke and tobacco heating system 2.2 aerosol by novel GC-MS deconvolution procedures

artículo científico publicado en 2020

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

scientific article published on 24 August 2020

Anthropometry-based generation of personalized and population-specific human airway models

artículo científico publicado en 2020

Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties

scientific article published on 03 July 2019

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

scientific article published on 07 September 2019

Aqueous cigarette smoke extract promotes the adhesion of monocytic cells to human coronary artery endothelial cells in direct and indirect-dependent ways

scholarly article by Carine Poussin et al published September 2014 in Toxicology Letters

Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

scientific article published on 14 February 2019

Assessment of Single-Photon Ionization Mass Spectrometry for Online Monitoring of in Vitro Aerosol Exposure Experiments

scientific article published on 07 January 2020

Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures

artículo científico publicado en 2019

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression

artículo científico publicado en 2014

Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use.

artículo científico publicado en 2016

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes

artículo científico publicado en 2018

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

artículo científico publicado en 2012

Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens

artículo científico publicado en 2018

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

scientific article published on 01 November 2018

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

artículo científico publicado en 2016

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

artículo científico publicado en 2020

Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond

artículo científico publicado en 2019

CSEO - the Cigarette Smoke Exposure Ontology

artículo científico publicado en 2014

Case study: the role of mechanistic network models in systems toxicology

artículo científico

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

artículo científico publicado en 2015

Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

artículo científico publicado en 2020

Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

Characterization of the Vitrocell® 24/48 aerosol exposure system for its use in exposures to liquid aerosols

artículo científico publicado en 2017

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

artículo científico publicado en 2014

Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.

artículo científico publicado en 2013

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.

artículo científico publicado en 2013

Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications

artículo científico publicado en 2016

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

artículo científico publicado en 2018

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

article

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

artículo científico publicado en 2016

Comparing the preclinical risk profile of inhalable candidate and potential candidate modified risk tobacco products: A bridging use case

artículo científico publicado en 2020

Comparison of experimentally measured and computational fluid dynamic predicted deposition and deposition uniformity of monodisperse solid particles in the Vitrocell® AMES 48 air-liquid-interface in-vitro exposure system

artículo científico publicado en 2020

Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products

artículo científico publicado en 2019

Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures

artículo científico publicado en 2020

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

artículo científico publicado en 2016

Computational Epigenomics: From Fundamental Research to Disease Prediction and Risk Assessment

Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data

artículo científico publicado en 2013

Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract

Construction of a computable cell proliferation network focused on non-diseased lung cells

artículo científico publicado en 2011

Construction of a computable network model for DNA damage, autophagy, cell death, and senescence

artículo científico

Construction of biological networks from unstructured information based on a semi-automated curation workflow

artículo científico publicado en 2015

Corrigendum to "The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product" published in Toxicology in Vitro, Volume 50, August 2018, Pages 95-108

artículo científico publicado en 2019

Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product

artículo científico publicado en 2017

Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures

artículo científico publicado en 2018

Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES)

artículo científico publicado en 2020

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™).

artículo científico publicado en 2014

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE-/- mouse model

artículo científico publicado en 2020

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis

artículo científico publicado en 2015

Effects of cigarette smoke and tobacco heating aerosol on color stability of dental enamel, dentin, and composite resin restorations

artículo científico publicado en 2018

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe -/- mice--a systems toxicology analysis

artículo científico publicado en 2016

Effects of cigarette smoking on color stability of dental resin composites

artículo científico publicado en 2017

Effects of different discoloration challenges and whitening treatments on dental hard tissues and composite resin restorations

scientific article published on 17 August 2019

Embracing Transparency Through Data Sharing

artículo científico publicado en 2018

Enhancement of COPD biological networks using a web-based collaboration interface.

artículo científico publicado en 2015

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

artículo científico publicado en 2020

Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program

artículo científico publicado en 2016

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke

artículo científico publicado en 2016

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke

artículo científico publicado en 2016

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke

artículo científico publicado en 2016

Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2.2.

artículo científico publicado en 2016

GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology

artículo científico publicado en 2019

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC).

artículo científico publicado en 2016

How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models

artículo científico publicado en 2019

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers

artículo científico publicado en 2013

Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

artículo científico publicado en 2020

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

artículo científico publicado en 2015

Impact assessment of repeated exposure of organotypic 3D bronchial and nasal tissue culture models to whole cigarette smoke

artículo científico publicado en 2015

Impact of sample preparation upon intracellular metabolite measurements in 3D cell culture systems

scientific article published on 12 June 2019

Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity

artículo científico publicado en 2020

In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air-Liquid Interface Cultures

artículo científico publicado en 2020

In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette.

artículo científico publicado en 2015

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

artículo científico publicado en 2014

In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells

scientific article published on 17 July 2018

Industrial methodology for process verification in research (IMPROVER): toward systems biology verification

artículo científico publicado en 2012

Inflammatory Bowel Disease-Associated Changes in the Gut: Focus on Kazan Patients

artículo científico publicado en 2020

Interrogating the microbiome: experimental and computational considerations in support of study reproducibility

artículo científico publicado en 2018

Lipid-based biomarkers for CVD, COPD, and aging - A translational perspective

scientific article published on 24 April 2020

Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice

scientific article published on 09 April 2020

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis

artículo científico publicado en 2014

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium

artículo científico publicado en 2017

Mechanistic Network Models in Safety and Toxicity Evaluation of Nutraceuticals

article

Mitochondria as a possible target for nicotine action

scientific article published on 13 June 2019

Mitochondrial Network and Biogenesis in Response to Short and Long-Term Exposure of Human BEAS-2B Cells to Aerosol Extracts from the Tobacco Heating System 2.2.

artículo científico publicado en 2020

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice

artículo científico publicado en 2012

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

artículo científico publicado en 2020

Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract

artículo científico publicado en 2017

NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

artículo científico publicado en 2019

Neurobehavioral effects of selected tobacco constituents in rodents following subchronic administration

artículo científico publicado en 2019

Novel approaches to develop community-built biological network models for potential drug discovery

artículo científico

On Crowd-verification of Biological Networks

artículo científico publicado en 2013

Physiological and biological characterization of smokers with and without COPD.

artículo científico publicado en 2017

Pre-malignant processes of smoking-induced lung adenocarcinoma development: A conceptual biological model

Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification

artículo científico publicado en 2018

Proteomics for systems toxicology

artículo científico publicado en 2014

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

artículo científico publicado en 2014

Quantifying the Biological Impact of Active Substances Using Causal Network Models

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

artículo científico publicado en 2013

Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice

artículo científico publicado en 2016

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol from a Heated Tobacco Product Compared with Cigarette Smoke

scientific article published on 11 August 2020

Reduced impact of a prototypic modified risk tobacco product compared with conventional cigarette smoke on exposed human and rat primary normal bronchial epithelial cells

scholarly article by Carole Mathis et al published September 2014 in Toxicology Letters

Reputation-based collaborative network biology

artículo científico publicado en 2015

Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles

scientific article published on 01 May 2019

Respiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice

scientific article published on 11 August 2020

Semi-Automated Curation Allows Causal Network Model Building for the Quantification of Age-Dependent Plaque Progression in ApoE-/- Mouse

artículo científico publicado en 2016

Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge

artículo científico publicado en 2013

Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smo

scientific article published on 06 November 2019

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure.

artículo científico publicado en 2017

Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset

artículo científico publicado en 2013

Systems Biology Approaches for Compound Testing

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion

artículo científico publicado en 2015

Systems Toxicology

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.

artículo científico publicado en 2016

Systems Toxicology: The Future of Risk Assessment

artículo científico publicado en 2015

Systems approaches evaluating the perturbation of xenobiotic metabolism in response to cigarette smoke exposure in nasal and bronchial tissues

artículo científico publicado en 2013

Systems biology approach for evaluating the biological impact of environmental toxicants in vitro

artículo científico publicado en 2014

Systems biology approach reveals a dose-dependent recovery of primary human airway epithelium culture after exposure to cigarette smoke

article

Systems toxicology approach for testing chemical cardiotoxicity in larval zebrafish

artículo científico publicado en 2020

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

artículo científico publicado en 2014

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells

artículo científico publicado en 2019

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells.

artículo científico publicado en 2015

Systems toxicology: from basic research to risk assessment

artículo científico publicado en 2014

Systems-toxicology approach to evaluate the biological impact of a subset of harmful/potentially harmful constituents of tobacco smoke

article by Ignacio Gonzalez-Suarez et al published August 2013 in Toxicology Letters

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

scientific article published on 01 January 2019

The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

artículo científico publicado en 2016

The Apoe-/- Mouse PhysioLab® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe-/- Mouse

The BEL information extraction workflow (BELIEF): evaluation in the BioCreative V BEL and IAT track

artículo científico publicado en 2016

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product

artículo científico publicado en 2018

The extraction of complex relationships and their conversion to biological expression language (BEL) overview of the BioCreative VI (2017) BEL track

artículo científico publicado en 2019

The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts

artículo científico publicado en 2020

The response of human nasal and bronchial organotypic tissue cultures to repeated whole cigarette smoke exposure

artículo científico publicado en 2014

The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status

artículo científico publicado en 2017

The species translation challenge-a systems biology perspective on human and rat bronchial epithelial cells

artículo científico publicado en 2014

The systems toxicology challenge

Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke

artículo científico publicado en 2018

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague-Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

artículo científico publicado en 2015

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints

artículo científico publicado en 2017

Toxicological assessment of Tobacco Heating System 2.2: Findings from an independent peer review

artículo científico publicado en 2019

Toxicopanomics: Applications of Genomics, Transcriptomics, Proteomics, and Lipidomics in Predictive Mechanistic Toxicology

Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL).

artículo científico

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

artículo científico publicado en 2015

Transcriptomics analysis revealed an indirect effect of aqueous cigarette smoke extract in promoting the adhesion of monocytic cells to endothelial cells.

artículo científico publicado en 2012

Translational systems biology understanding the limits of animal models as predictors of human biology

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

artículo científico publicado en 2014

Verification of systems biology research in the age of collaborative competition

artículo científico publicado en 2011

sbv IMPROVER Diagnostic Signature Challenge

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