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Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels

artículo científico publicado en 2010

Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis

artículo científico publicado en 2014

Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer

artículo científico publicado en 2014

Corrigendum: identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

artículo científico publicado en 2015

DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway

artículo científico publicado en 2016

DYRK1B regulates Hedgehog-induced microtubule acetylation

article

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

artículo científico publicado en 2010

Developmental upregulation of an alternative form of pcp2 with reduced GDI activity.

artículo científico publicado en 2014

Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas

artículo científico publicado en 2011

Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control

artículo científico publicado en 2017

GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells

artículo científico publicado en 2011

Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway

Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury

artículo científico publicado en 2018

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

scientific journal article

Genetic targeting of cerebellar Purkinje cells: history, current status and novel strategies

artículo científico publicado en 2002

Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1.

artículo científico publicado en 2010

Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors

artículo científico publicado en 2011

Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms

artículo científico publicado en 2011

Hedgehog signaling and pancreatic tumor development

artículo científico publicado en 2011

Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway

artículo científico publicado en 2014

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

artículo científico publicado en 2015

Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies

scientific article published on 24 April 2019

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

artículo científico publicado en 2007

Inhibition of GLI1 gene activation by Patched1

artículo científico publicado en 2006

Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms

artículo científico publicado en 2014

Insert-containing neurotrophins in teleost fish and their relationship to nerve growth factor

artículo científico publicado en 2003

Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy

artículo científico publicado en 2007

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal

artículo científico

Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors

artículo científico publicado en 2017

RAS and Hedgehog - partners in crime

artículo científico publicado el 1 de junio de 2011

RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling

artículo científico publicado en 2013

Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.

artículo científico publicado en 2013

Sonic the Hedgehog: A game about aging? Emerging evidence for anti-geriatric effects of Hedgehog signaling (retrospective on DOI 10.1002/bies.201200049).

artículo científico publicado en 2014

Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases

artículo científico publicado en 2002

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

artículo científico publicado en 2018

The Hedgehog pathway as a drug target in cancer therapy.

artículo científico publicado en 2007

The Immune Microenvironment in Pancreatic Cancer

artículo científico publicado en 2020

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

artículo científico publicado en 2015

The role of pancreatic and duodenal homeobox 1 as a therapeutic target in pancreatic cancer

artículo científico publicado en 2014

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

artículo científico publicado en 2019

Think inside the BOCs: a mechanism underlying medulloblastoma progression

artículo científico publicado en 2014

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