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1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase.

artículo científico publicado en 2011

A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study

artículo científico publicado en 2015

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

artículo científico publicado en 2013

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

article by Sven J. van der Lee et al published 27 May 2019 in Acta Neuropathologica

Association Between Osteoarthritis and Social Isolation: Data From the EPOSA Study

artículo científico publicado en 2019

Associations Between Statin Use and Physical Function in Older Adults from The Netherlands and Australia: Longitudinal Aging Study Amsterdam and Australian Longitudinal Study on Women's Health

artículo científico publicado en 2016

Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study

artículo científico publicado en 2014

Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures; the Longitudinal Aging Study Amsterdam.

artículo científico publicado en 2017

B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study

artículo científico publicado en 2019

Beta-blocker use and fall risk in older individuals: Original results from two studies with meta-analysis

artículo científico publicado en 2017

CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis.

artículo científico publicado en 2016

Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease.

artículo científico publicado en 2018

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults

artículo científico publicado en 2018

Changes in vitamin D endocrinology during aging in adults

artículo científico publicado en 2017

Changes of Vitamin D-Binding Protein, and Total, Bioavailable, and Free 25-Hydroxyvitamin D in Transgender People

artículo científico publicado en 2019

Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.

artículo científico publicado en 2013

Cognitive Performance: A Cross-Sectional Study on Serum Vitamin D and Its Interplay With Glucose Homeostasis in Dutch Older Adults

artículo científico publicado en 2015

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

artículo científico publicado en 2021

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Correction: Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

artículo científico publicado en 2006

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Cost-effectiveness of hip protectors in frail institutionalized elderly

artículo científico publicado en 2004

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Development of a clinical prediction model for the onset of functional decline in people aged 65-75 years: pooled analysis of four European cohort studies

scientific article published on 27 June 2019

Diet, sun, and lifestyle as determinants of vitamin D status

artículo científico publicado en 2014

Different cognitive functions in relation to falls among older persons. Immediate memory as an independent risk factor for falls.

artículo científico publicado en 2002

Disentangling the genetics of lean mass

article

Distinct trajectories of individual physical performance measures across nine years in 60- to 70-year-old adults

artículo científico publicado en 2020

Distinguishing four components underlying physical activity: a new approach to using physical activity questionnaire data in old age

artículo científico publicado en 2010

Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health?

scientific article published on 14 October 2019

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

artículo científico publicado en 2019

Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts

Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial

artículo científico publicado en 2015

Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial

artículo científico publicado en 2015

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

artículo científico publicado en 2014

Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia

artículo científico

Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial

artículo científico publicado en 2015

Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT.

artículo científico publicado en 2016

Effects of vitamin D supplementation on markers for cardiovascular disease and type 2 diabetes: an individual participant data meta-analysis of randomized controlled trials.

artículo científico publicado en 2018

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

artículo científico publicado en 2017

European Project on OSteoArthritis (EPOSA): methodological challenges in harmonization of existing data from five European population-based cohorts on aging

artículo científico publicado en 2011

European project on osteoarthritis: design of a six-cohort study on the personal and societal burden of osteoarthritis in an older European population

artículo científico publicado en 2013

Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

artículo científico publicado en 2018

Factors associated with functional decline in hand and hip/knee osteoarthritis after a year's time: Data from the eposa study

artículo científico publicado en 2020

Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial

Folic acid and vitamin-B12 supplementation and the risk of cancer: long-term follow-up of the B-vitamins for the Prevention Of Osteoporotic Fractures (B-PROOF) trial

article published in 2018

Functioning Without Cartilage: Older People With Radiographic Knee Osteoarthritis Who Self-Report No Functional Limitations Do Score Lower on a Performance Battery.

artículo científico publicado en 2017

Gender-specific associations between physical functioning, bone quality, and fracture risk in older people

artículo científico publicado en 2014

Genetic Liability for Depression, Social Factors and Their Interaction Effect in Depressive Symptoms and Depression Over Time in Older Adults

scientific article published on 08 March 2020

Genetic basis of falling risk susceptibility in the UK Biobank Study

artículo científico publicado en 2020

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

artículo científico publicado en 2014

Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition

Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus

artículo científico publicado en 2014

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

artículo científico publicado en 2012

Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction

artículo científico publicado en 2009

Homocysteine level is associated with aortic stiffness in elderly

artículo científico publicado en 2013

How Hand Osteoarthritis, Comorbidity, and Pain Interact to Determine Functional Limitation in Older People: Observations From the European Project on OSteoArthritis Study.

artículo científico publicado en 2016

Immune response and endocytosis pathways are associated with the resilience against Alzheimer's disease

artículo científico publicado en 2020

Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures

artículo científico publicado en 2004

Joint Association of Low Vitamin D and Vitamin K Status With Blood Pressure and Hypertension

artículo científico publicado en 2017

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

scholarly article

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

artículo científico publicado en 2019

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

artículo científico publicado en 2017

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

artículo científico publicado en 2008

Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study

artículo científico publicado en 2007

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study

artículo científico publicado en 2006

Lipid levels: a link between cardiovascular disease and osteoporosis?

artículo científico publicado en 2009

Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

scientific article published on 05 August 2020

Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men.

artículo científico publicado en 2009

Low grade inflammation is associated with lower velocity of sound and broadband ultrasound attenuation in older men, but not with bone loss or fracture risk in a longitudinal aging study

artículo científico publicado en 2015

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article published on 01 December 2018

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

artículo científico publicado en 2017

Maximum potential preventive effect of hip protectors

artículo científico publicado en 2007

Medication-related fall incidents in an older, ambulant population: the B-PROOF study

artículo científico

Minimal clinically important decline in physical function over one year: EPOSA study

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

artículo científico publicado en 2016

Non-linear associations between serum 25-OH vitamin D and indices of arterial stiffness and arteriosclerosis in an older population.

artículo científico publicado en 2014

Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data

artículo científico publicado en 2017

Oscillometry and applanation tonometry measurements in older individuals with elevated levels of arterial stiffness.

artículo científico publicado en 2013

Osteocalcin as a predictor of the metabolic syndrome in older persons: a population-based study.

artículo científico publicado en 2013

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

scientific article published on 12 March 2020

PTH: A New Target in Arteriosclerosis?

artículo científico publicado en 2013

Physical Activity Patterns Among Older Adults With and Without Knee Osteoarthritis in Six European Countries

artículo científico publicado en 2015

Physical activity and incident clinical knee osteoarthritis in older adults

artículo científico publicado en 2009

Physical activity as moderator of the association between APOE and cognitive decline in older adults: Results from three longitudinal cohort studies

scientific article published on 28 February 2020

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

scientific article published on 06 May 2014

Polygenic risk score of longevity predicts longer survival across an age-continuum

artículo científico publicado en 2020

Pre-analytical stability of FGF23 with the contemporary immunoassays

scientific article published on 01 March 2019

Predicting Trajectories of Functional Decline in 60- to 70-Year-Old People

artículo científico publicado en 2017

Prediction of vitamin D deficiency by simple patient characteristics

artículo científico publicado en 2014

Predictors of metabolic syndrome in community-dwelling older adults

scientific article published in PLoS ONE

Prevention of Hip Fractures by External Hip Protectors

artículo científico publicado en 2003

Psychosocial and Health-Related Factors Associated With Discordance Between 13-Year Trajectories of Self-Reported Functional Limitations and Performance-Based Physical Functioning in Old Age

artículo científico publicado en 2019

Quality of life in patients with osteoporosis

artículo científico publicado en 2004

Rare and low-frequency coding variants alter human adult height

artículo científico publicado en 2017

Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper

article

Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence

artículo científico publicado en 2011

Reducing fracture risk with calcium and vitamin D.

scientific article published on September 2010

Relationships between physical performance and knee and hip osteoarthritis: findings from the European Project on Osteoarthritis (EPOSA)

artículo científico publicado en 2014

Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons

scientific article published on 21 January 2009

Relative importance of four functional measures as predictors of 15-year mortality in the older Dutch population

Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study

artículo científico publicado en 2015

Results of 2-year vitamin B treatment on cognitive performance: secondary data from an RCT.

artículo científico publicado en 2014

Role of Osteoarthritis, Comorbidity, and Pain in Determining Functional Limitations in Older Populations: European Project on Osteoarthritis

artículo científico publicado en 2015

Self-Reported Loss of Consciousness After Head Trauma Does Not Predispose to Hypopituitarism in an Older Population

artículo científico publicado el 1 de enero de 2011

Serum 25-hydroxyvitamin D levels and the metabolic syndrome in older persons: a population-based study

artículo científico publicado en 2011

Serum insulin-like growth factor-I and body composition in community dwelling older people

scientific article published on 11 November 2009

Should prevention of falls start earlier? Co-ordinated analyses of harmonised data on falls in middle-aged adults across four population-based cohort studies

artículo científico publicado en 2018

Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: a randomized clinical trial

artículo científico publicado el 4 de agosto de 2010

Systematic Review of the Relationship between Vitamin D and Parkinson's Disease

artículo científico publicado en 2016

The Association Between Serum 25-hydroxy Vitamin D Level and Upper Leg Strength in Patients with Knee Osteoarthritis: Results of the Amsterdam Osteoarthritis Cohort

artículo científico publicado en 2016

The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial

artículo científico publicado en 2019

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings

scientific article published on 20 August 2016

The Longitudinal Aging Study Amsterdam: cohort update 2019 and additional data collections

artículo científico publicado en 2019

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data

article

The association between apathy, decline in physical performance, and falls in older persons

scientific article published on 02 January 2019

The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis

artículo científico publicado en 2006

The association between high-molecular-weight adiponectin, ghrelin and leptin and age-related cognitive decline: results from Longitudinal Aging Study Amsterdam

scientific article published on 24 May 2020

The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women

artículo científico publicado en 2005

The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women

scientific article published on 06 June 2007

The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions.

artículo científico publicado en 2012

The effect of vitamin D on bone and osteoporosis

artículo científico publicado en 2011

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

artículo científico publicado en 2015

The relationship between serum 25(OH)D levels and anxiety symptoms in older persons: Results from the Longitudinal Aging Study Amsterdam

artículo científico publicado en 2017

Thyroid function and the metabolic syndrome in older persons: a population-based study

artículo científico publicado en 2012

Trends across 20 years in multiple indicators of functioning among older adults in the Netherlands

scientific article published on 01 December 2019

Trends in lifestyle among three cohorts of adults aged 55-64 years in 1992/1993, 2002/2003 and 2012/2013.

artículo científico publicado en 2017

Unhealthy lifestyles during the life course: association with physical decline in late life

artículo científico publicado en 2007

Validation of the LASA fall risk profile for recurrent falling in older recent fallers

artículo científico

Vitamin B12, folic acid, and bone

artículo científico

Vitamin D Status Predicts Physical Performance and Its Decline in Older Persons

scientific article published on 06 March 2007

Vitamin D Status and Depressive Symptoms in Older Adults: A Role for Physical Functioning?

artículo científico publicado en 2018

Vitamin D and Memory Decline: Two Population-Based Prospective Studies.

artículo científico publicado en 2016

Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

artículo científico publicado en 2017

Vitamin D deficiency in Europe: pandemic?

artículo científico publicado en 2016

Vitamin D receptor gene haplotype is associated with body height and bone size

artículo científico publicado en 2007

Vitamin D status in relation to one-year risk of recurrent falling in older men and women

artículo científico

Vitamin D status, parathyroid function, bone turnover, and BMD in postmenopausal women with osteoporosis: global perspective

artículo científico publicado en 2009

Vitamin D supplementation for the prevention of depression and poor physical function in older persons: the D-Vitaal study, a randomized clinical trial

artículo científico publicado en 2019

Vitamin D supplementation to prevent depression and poor physical function in older adults: Study protocol of the D-Vitaal study, a randomized placebo-controlled clinical trial

artículo científico publicado en 2015

Vitamin D supplements with or without calcium to prevent fractures

artículo científico publicado en 2014

Vitamin D, PTH and the risk of overall and disease-specific mortality: Results of the Longitudinal Aging Study Amsterdam.

artículo científico publicado en 2015

Which types of activities are associated with risk of recurrent falling in older persons?

artículo científico publicado en 2010

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

artículo científico publicado en 2015

Within-Person Pain Variability and Mental Health in Older Adults With Osteoarthritis: An Analysis Across 6 European Cohorts.

artículo científico publicado en 2018

Within-person pain variability and physical activity in older adults with osteoarthritis from six European countries

artículo científico publicado en 2019

Worldwide vitamin D status

artículo científico publicado en 2011

[Bone densitometry: widening the indication is neither effective nor efficient]

artículo científico publicado en 2010

[Implementation of the Dutch vitamin D supplementation advice: report of an expert meeting]