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(+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38.

artículo científico publicado en 2014

(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.

artículo científico publicado en 2006

(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase

artículo científico publicado en 2008

(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells

artículo científico publicado en 2012

2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells

artículo científico publicado en 2005

20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-Induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway

artículo científico publicado en 2014

20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx.

artículo científico publicado en 2013

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells

artículo científico publicado en 2015

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2

scientific article published on 01 February 2019

3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer

artículo científico publicado en 2014

5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer

artículo científico publicado en 2010

6,7,4'-Trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2 ⬇️

artículo científico publicado el 21 de enero de 2011

6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1.

artículo científico publicado en 2013

7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase

artículo científico publicado en 2010

7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.

artículo científico publicado en 2011

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

artículo científico publicado en 2015

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo.

artículo científico publicado en 2017

A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells

artículo científico publicado en 2013

A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development

artículo científico publicado en 2004

A regulatory mechanism for RSK2 NH(2)-terminal kinase activity

artículo científico publicado en 2009

A selective small-molecule inhibitor of c-Jun N-terminal kinase 1

artículo científico publicado en 2009

ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK.

artículo científico publicado en 2017

AKT as a Therapeutic Target for Cancer

scientific article published on 26 February 2019

APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model

artículo científico publicado en 2017

ARC is a critical protector against inflammatory bowel disease (IBD) and IBD-associated colorectal tumorigenesis

scientific article published on 19 August 2020

Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells

artículo científico publicado en 2013

Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin

artículo científico publicado en 2015

Addressing the challenges of applying precision oncology.

artículo científico publicado en 2017

Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2

artículo científico publicado en 2012

Analysis of hydrophobic and hydrophilic moments of short penetrating peptides for enhancing mitochondrial localization: prediction and validation

scientific article published on 27 March 2019

Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells

artículo científico publicado en 2006

Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression

artículo científico publicado en 2015

Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.

artículo científico publicado en 2003

Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma

scientific article published on 01 March 2019

Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells

artículo científico publicado en 2013

Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase

artículo científico publicado en 2016

Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells

artículo científico publicado en 2007

Breaking the NF-κB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis ⬇️

artículo científico publicado el 26 de octubre de 2010

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth

artículo científico publicado en 2014

CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction

scientific article published on 25 June 2019

CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo

artículo científico publicado en 2013

COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.

artículo científico publicado en 2006

CRISPR/Cas9 - An evolving biological tool kit for cancer biology and oncology

article published in 2019

Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.

artículo científico publicado en 2014

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression

artículo científico publicado en 2008

Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells

artículo científico publicado en 2004

Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2

Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B ⬇️

artículo científico publicado el 7 de septiembre de 2012

Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

artículo científico publicado en 2006

Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance

artículo científico publicado en 2015

Circulating Tumor Cells: Moving Biological Insights into Detection.

artículo científico publicado en 2017

Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.

artículo científico publicado en 2010

Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase

artículo científico publicado en 2008

Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK ⬇️

artículo científico publicado el 11 de febrero de 2011

Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity

artículo científico publicado en 2007

Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation

artículo científico publicado en 2008

Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.

artículo científico publicado en 2009

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

artículo científico publicado en 2002

Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling

artículo científico publicado en 2008

Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase

artículo científico publicado en 2009

Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells.

artículo científico publicado en 2002

Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation

scientific article published on 01 March 2007

Discovery of Novel Checkpoint Kinase 1 Inhibitors by Virtual Screening Based on Multiple Crystal Structures ⬇️

artículo científico publicado el 12 de octubre de 2011

Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer

scientific article published on 22 September 2020

Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo

artículo científico publicado en 2013

EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma ⬇️

artículo científico publicado el 17 de noviembre de 2011

EBV-Encoded LMP1 Upregulates Igκ 3′Enhancer Activity and Igκ Expression in Nasopharyngeal Cancer Cells by Activating the Ets-1 through ERKs Signaling ⬇️

artículo científico publicado el 1 de enero de 2012

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

artículo científico publicado en 2015

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

scientific article published on 13 April 2014

Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes

artículo científico publicado en 2006

Embryonic stem‐cell‐preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells ⬇️

artículo científico publicado el 16 de agosto de 2011

Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail

artículo científico publicado en 2009

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

artículo científico publicado en 2011

Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma ⬇️

artículo científico publicado el 17 de enero de 2012

Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway

artículo científico publicado en 2007

Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation ⬇️

artículo científico publicado el 22 de noviembre de 2010

Erratum

Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin

artículo científico publicado en 2013

Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth

scientific article published on 21 December 2018

Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling

artículo científico publicado en 2014

Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer

artículo científico publicado en 2010

Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis

scientific article published on 25 September 2019

Four Is Better Than 1-Strength in Numbers!

artículo científico publicado en 2016

Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation

artículo científico publicado en 2008

GSK3β-mediated expression of CUG-translated WT1 is critical for tumor progression

artículo científico publicado en 2020

Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17

artículo científico publicado en 2015

Glycolytic genes in cancer cells are more than glucose metabolic regulators

artículo científico publicado en 2014

Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo

artículo científico publicado en 2018

HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E

scientific article published on 01 August 2020

Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation

artículo científico publicado en 2014

Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.

artículo científico publicado en 2012

Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo

artículo científico publicado en 2012

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer

artículo científico publicado en 2016

Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.

artículo científico publicado en 2003

Inhibiting breast cancer by targeting the thromboxane A2 pathway.

artículo científico publicado en 2017

Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin

artículo científico publicado en 2016

Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

artículo científico publicado en 2019

Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship

artículo científico publicado en 2008

Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells

artículo científico publicado en 2004

Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).

artículo científico publicado en 2007

Involvement of the paxillin pathway in JB6 Cl41 cell transformation

artículo científico publicado en 2006

Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma

scientific article published on 08 October 2013

Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.

artículo científico publicado en 2014

Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.

artículo científico publicado en 2011

JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

artículo científico publicado en 2013

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

artículo científico publicado en 2010

Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer

artículo científico publicado en 2014

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells

scientific article published on 19 May 2020

Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells

scientific article published on 01 September 2019

LTA4H regulates cell cycle and skin carcinogenesis.

artículo científico publicado en 2017

Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1.

artículo científico publicado en 2013

Lin28a expression protects against streptozotocin-induced β-cell destruction and prevents diabetes in mice

artículo científico publicado en 2019

Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization

artículo científico publicado en 2018

Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer

artículo científico publicado en 2010

Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.

artículo científico publicado en 2006

MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes

artículo científico publicado en 2013

MST1 promotes apoptosis through phosphorylation of histone H2AX

artículo científico publicado en 2010

Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation

artículo científico publicado en 2008

Molecular and cellular targets

artículo científico publicado en 2006

Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging

artículo científico

Molecular targets of phytochemicals for cancer prevention ⬇️

artículo científico publicado el 10 de febrero de 2011

Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo

artículo científico publicado en 2009

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.

artículo científico publicado en 2007

Myricetin suppresses UVB-induced skin cancer by targeting Fyn.

artículo científico publicado en 2008

Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.

artículo científico publicado en 2010

Naringenin targets ERK2 and suppresses UVB-induced photoaging

artículo científico publicado en 2016

Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

artículo científico publicado en 2015

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

artículo científico publicado en 2016

Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

artículo científico publicado en 2012

Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth

artículo científico publicado en 2012

Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation

artículo científico publicado en 2007

Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A

artículo científico publicado en 2022

P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation

artículo científico publicado en 2011

PKCι is a target of 7,8,4'-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression.

artículo científico publicado en 2017

PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts

artículo científico publicado en 2016

Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3

artículo científico publicado en 2021

Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

artículo científico publicado en 2018

Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation

artículo científico publicado en 2011

Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha

artículo científico publicado en 2005

Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells ⬇️

artículo científico publicado el 1 de diciembre de 2010

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines

artículo científico publicado en 2011

Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.

artículo científico publicado en 2010

Phosphorylation of histone H2B serine 32 is linked to cell transformation.

artículo científico publicado en 2011

Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation

artículo científico publicado en 2005

Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells

artículo científico publicado en 2003

Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation ⬇️

artículo científico publicado el 28 de julio de 2012

Precision medicine: the foundation of future cancer therapeutics

artículo científico publicado en 2017

Precision oncology- the future of personalized cancer medicine?

artículo científico publicado en 2017

Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods

artículo científico publicado en 2012

Proceedings--targeting carcinogenesis: transduction, transcription, translation

artículo científico publicado en 2006

Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light

artículo científico publicado en 2017

Purpurogallin is a novel mitogen-activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo

artículo científico publicado en 2019

Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.

artículo científico publicado en 2011

Quercetin‐3‐methyl ether inhibits lapatinib‐sensitive and ‐resistant breast cancer cell growth by inducing G2/M arrest and apoptosis ⬇️

artículo científico publicado el 15 de noviembre de 2011

RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor

scientific article published on 14 August 2020

RSK2 as a key regulator in human skin cancer

artículo científico publicado en 2012

RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation

artículo científico publicado en 2018

RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway.

artículo científico publicado en 2010

RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth

artículo científico publicado en 2017

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine

artículo científico publicado en 2008

Recent advances in precision oncology research

scientific article published on 16 April 2018

Regulation of microRNAs by epigenetics and their interplay involved in cancer

artículo científico publicado en 2013

Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase

artículo científico publicado en 2004

Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity ⬇️

artículo científico publicado el 12 de julio de 2012

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin

artículo científico publicado en 2016

Resveratrol directly targets COX-2 to inhibit carcinogenesis.

artículo científico publicado en 2008

Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase

artículo científico publicado en 2010

Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation ⬇️

artículo científico publicado en 2007

Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells

artículo científico publicado en 2010

SDCBP/MDA-9/syntenin phosphorylation by AURKA promotes esophageal squamous cell carcinoma progression through the EGFR-PI3K-Akt signaling pathway

artículo científico publicado en 2020

Scutellarin Suppresses Patient-Derived Xenograft Tumor Growth by Directly Targeting AKT in Esophageal Squamous Cell Carcinoma

scientific article published on 25 September 2019

Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2

artículo científico publicado en 2013

Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells

artículo científico publicado en 2017

Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells

artículo científico publicado en 2014

Structural and functional analysis of the natural JNK1 inhibitor quercetagetin

artículo científico publicado en 2013

Structural basis for multifunctional roles of human Ints3 C-terminal domain

scientific article published on 23 November 2020

Sunlight UV-induced skin cancer relies upon activation of the p38α signaling pathway

artículo científico publicado en 2013

T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway

scientific journal article

T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity

artículo científico publicado en 2010

T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation

artículo científico publicado en 2007

TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis

artículo científico publicado en 2017

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis

artículo científico publicado en 2018

TRAF4 is a critical molecule for Akt activation in lung cancer.

artículo científico publicado en 2013

TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling ⬇️

artículo científico publicado el 23 de febrero de 2011

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

scientific article published on 03 April 2019

Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo.

artículo científico publicado en 2018

Targeting PRPK Function Blocks Colon Cancer Metastasis

artículo científico publicado en 2018

Targeting PRPK and TOPK for skin cancer prevention and therapy

scientific article published on 14 June 2018

Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

artículo científico publicado en 2017

Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development

scientific article published on 07 November 2019

Taxifolin Suppresses UV-Induced Skin Carcinogenesis by Targeting EGFR and PI3K ⬇️

artículo científico publicado el 17 de julio de 2012

The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K

artículo científico publicado en 2018

The CUG-translated WT1, not AUG-WT1, is an oncogene

artículo científico publicado en 2017

The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1

artículo científico publicado en 2010

The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer

artículo científico publicado en 2013

The PGC-1/ERR network and its role in precision oncology

The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4'-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth

artículo científico publicado en 2017

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis ⬇️

artículo científico publicado el 20 de julio de 2012

The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications

artículo científico publicado en 2016

The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis

artículo científico publicado en 2017

The Two Faces of Capsaicin ⬇️

artículo científico publicado el 12 de abril de 2011

The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development

artículo científico publicado en 2008

The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1.

artículo científico publicado en 2014

The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer

artículo científico publicado en 2016

The functional contrariety of JNK

artículo científico publicado en 2007

The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation

artículo científico publicado en 2014

The intermediate filament protein vimentin is a new target for epigallocatechin gallate

artículo científico publicado en 2005

The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.

artículo científico publicado en 2005

The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK

artículo científico publicado en 2008

The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1

artículo científico publicado en 2015

The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation

artículo científico publicado en 2006

The role of necroptosis, an alternative form of cell death, in cancer therapy ⬇️

artículo científico publicado el 1 de julio de 2013

The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.

artículo científico publicado en 2004

The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity

artículo científico publicado en 2005

Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation.

artículo científico publicado en 2006

Therapies based on targeting Epstein-Barr virus lytic replication for EBV-associated malignancies.

artículo científico publicado en 2018

Toxic phytochemicals and their potential risks for human cancer

artículo científico publicado en 2015

Tpl2 is a key mediator of arsenite-induced signal transduction

artículo científico publicado en 2009

Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

artículo científico publicado en 2009

Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway

artículo científico publicado en 2012

Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma

artículo científico publicado en 2013

USP8 is a novel target for overcoming gefitinib resistance in lung cancer

scientific article published on 07 June 2013

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research ⬇️

artículo científico publicado el 1 de diciembre de 2010

Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA.

artículo científico publicado en 2017

[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase

artículo científico publicado en 2009

miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma

artículo científico publicado en 2015

p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor

artículo científico publicado en 2003

p38α MAPK is required for arsenic-induced cell transformation

artículo científico publicado en 2016

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