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AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys

artículo científico publicado en 2020

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

artículo científico publicado en 2010

Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing

artículo científico publicado en 2017

Characterization of a Novel FLT3 BiTE® Antibody Construct for the Treatment of Acute Myeloid Leukemia

artículo científico publicado en 2020

Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes

scientific article published on 18 April 2019

Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing

scientific article published on 01 April 2020

Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor

artículo científico publicado en 2015

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C

artículo científico publicado en 2019

Hepcidin regulation in prostate and its disruption in prostate cancer.

artículo científico publicado en 2015

Hepcidin revisited, disulfide connectivity, dynamics, and structure

artículo científico publicado en 2009

High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow

artículo científico publicado en 2015

IL-22 regulates iron availability in vivo through the induction of hepcidin

artículo científico publicado en 2013

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

artículo científico publicado en 2017

Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.

artículo científico publicado en 2012

Nonclinical Safety Assessment of AMG 553, an Investigational Chimeric Antigen Receptor (CAR) T-cell Therapy for the Treatment of Acute Myeloid Leukemia

artículo científico publicado en 2020

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

artículo científico publicado en 2016

Oxidative folding of hepcidin at acidic pH.

artículo científico publicado en 2010

Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI).

artículo científico publicado en 2010

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

artículo científico publicado en 2020

Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.

artículo científico publicado en 2015

Systematic Study of the Glutathione (GSH) Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution

scientific article published on 23 September 2020

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

artículo científico publicado en 2019

The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models

artículo científico publicado en 2020