Lista de obras -

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

artículo científico publicado en 2004

A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice

artículo científico publicado en 2005

A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity

artículo científico publicado en 2014

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB

scientific journal article

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

artículo científico publicado en 2009

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants

artículo científico publicado en 2004

Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity

artículo científico publicado en 2011

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling

artículo científico publicado en 2016

Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol

artículo científico publicado en 2003

Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor

artículo científico publicado en 2005

Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways

artículo científico publicado en 2008

Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test

artículo científico publicado en 2007

C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation

scientific article published on 03 October 2019

CR/periphilin is a transcriptional co-repressor involved in cell cycle progression

artículo científico publicado en 2007

Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease

artículo científico publicado en 2017

Calmodulin-like skin protein suppresses the increase in senescence-associated β-galactosidase induced by hydrogen peroxide or ultraviolet irradiation in keratinocytes

scientific article published on 18 May 2019

Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons

artículo científico publicado en 2004

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

artículo científico publicado en 2006

Colivelin prolongs survival of an ALS model mouse

scientific article published on 10 March 2006

Cytoplasmic tail adaptors of Alzheimer's amyloid-beta protein precursor

artículo científico publicado en 2004

Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.

artículo científico publicado en 2004

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

artículo científico publicado en 2007

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro

artículo científico publicado en 2005

ER stress and unfolded protein response in amyotrophic lateral sclerosis

scientific article published on 30 January 2009

Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity

artículo científico publicado en 2005

Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag

artículo científico publicado en 2005

Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

artículo científico publicado en 2015

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis

artículo científico publicado en 2006

Humanin and the receptors for humanin

scientific article published on 09 December 2009

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin

artículo científico publicado en 2004

Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130

artículo científico publicado en 2009

Humanin: after the discovery.

artículo científico publicado en 2004

Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin

artículo científico publicado en 2009

Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory

artículo científico publicado en 2005

Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection

artículo científico publicado en 2005

KCTD20, a relative of BTBD10, is a positive regulator of Akt

scientific journal article

MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins ⬇️

artículo científico publicado el 1 de marzo de 2012

Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.

artículo científico publicado en 2004

Multiple domains of the mouse p19ARF tumor suppressor are involved in p53-independent apoptosis

artículo científico publicado en 2003

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease

artículo científico publicado en 2007

Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin.

artículo científico publicado en 2007

Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo.

artículo científico publicado en 2004

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs

artículo científico publicado en 2014

Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest

artículo científico publicado en 2004

Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells ⬇️

artículo científico publicado el 23 de noviembre de 2011

Practical pharmacology training method for undergraduate medical students using a pharmacokinetic simulation model ⬇️

artículo científico publicado el 1 de septiembre de 2010

Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP‐43‐positive inclusions in patients with sporadic amyotrophic lateral sclerosis ⬇️

artículo científico publicado el 16 de enero de 2013

S-nitrosothiol depletion in amyotrophic lateral sclerosis

artículo científico publicado en 2006

SH3-binding Protein 5 Mediates the Neuroprotective Effect of the Secreted Bioactive Peptide Humanin by Inhibiting c-Jun NH2-terminal Kinase ⬇️

artículo científico publicado el 16 de julio de 2013

Secreted calmodulin-like skin protein ameliorates scopolamine-induced memory impairment ⬇️

artículo científico publicado el 18 de junio de 2014

TAG-1 is an inhibitor of TGFbeta2-induced neuronal death via amyloid beta precursor protein

artículo científico publicado en 2010

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

artículo científico publicado en 2011

TDP‐43 toxicity is mediated by the unfolded protein response‐unrelated induction of C/EBP homologous protein expression ⬇️

artículo científico publicado el 4 de noviembre de 2011

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.

artículo científico publicado en 2004

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

scientific journal article

The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain

artículo científico publicado en 2004

The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death

artículo científico publicado en 2016

The effect of self-training in advance using an e-learning system on pharmacological practice

artículo científico publicado en 2015

The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis

scholarly article by Hiroaki Suzuki et al published 24 September 2018 in Cell Death and Disease

Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta.

artículo científico publicado en 2006

Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein

artículo científico publicado en 2005

Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains

artículo científico publicado en 2010

Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal

artículo científico publicado en 2007

[Practical training of pharmacokinetics with an web-based simulation application]

artículo científico publicado en 2020

d -Amino acid oxidase controls motoneuron degeneration through d -serine ⬇️

artículo científico publicado el 27 de diciembre de 2011

ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways

artículo científico publicado en 2003

p19ARF-induced p53-independent apoptosis largely occurs through BAX.

artículo científico publicado en 2003

p53-independent apoptosis is induced by the p19ARF tumor suppressor

artículo científico publicado en 2002

Lista de obras de

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice

A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants

Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling

Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol

Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor

Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways

Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test

C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation

CR/periphilin is a transcriptional co-repressor involved in cell cycle progression

Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease

Calmodulin-like skin protein suppresses the increase in senescence-associated β-galactosidase induced by hydrogen peroxide or ultraviolet irradiation in keratinocytes

Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

Colivelin prolongs survival of an ALS model mouse

Cytoplasmic tail adaptors of Alzheimer's amyloid-beta protein precursor

Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro

ER stress and unfolded protein response in amyotrophic lateral sclerosis

Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity

Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag

Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis

Humanin and the receptors for humanin

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin

Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130

Humanin: after the discovery.

Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin

Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory

Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection

KCTD20, a relative of BTBD10, is a positive regulator of Akt

MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins ⬇️

Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.

Multiple domains of the mouse p19ARF tumor suppressor are involved in p53-independent apoptosis

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease

Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin.

Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo.

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs

Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest

Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells ⬇️

Practical pharmacology training method for undergraduate medical students using a pharmacokinetic simulation model ⬇️

Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP‐43‐positive inclusions in patients with sporadic amyotrophic lateral sclerosis ⬇️

S-nitrosothiol depletion in amyotrophic lateral sclerosis

SH3-binding Protein 5 Mediates the Neuroprotective Effect of the Secreted Bioactive Peptide Humanin by Inhibiting c-Jun NH2-terminal Kinase ⬇️

Secreted calmodulin-like skin protein ameliorates scopolamine-induced memory impairment ⬇️

TAG-1 is an inhibitor of TGFbeta2-induced neuronal death via amyloid beta precursor protein

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

TDP‐43 toxicity is mediated by the unfolded protein response‐unrelated induction of C/EBP homologous protein expression ⬇️

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain

The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death

The effect of self-training in advance using an e-learning system on pharmacological practice

The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis

Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta.

Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein

Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains

Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal

[Practical training of pharmacokinetics with an web-based simulation application]

d -Amino acid oxidase controls motoneuron degeneration through d -serine ⬇️

ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways

p19ARF-induced p53-independent apoptosis largely occurs through BAX.

p53-independent apoptosis is induced by the p19ARF tumor suppressor