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A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease

artículo científico publicado en 2012

A neuroglobin-overexpressing transgenic mouse

artículo científico publicado en 2007

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

artículo científico publicado en 2000

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

artículo científico publicado en 2016

Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease

artículo científico publicado en 2017

An Artificially Designed Pore-forming Protein with Anti-tumor Effects ⬇️

artículo científico publicado el 14 de mayo de 2003

Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

artículo científico publicado en 2004

Anti-cancer activity of targeted pro-apoptotic peptides

artículo científico publicado en 1999

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

artículo científico publicado en 2005

Autophagy: polyQ toxic fragment turnover

artículo científico publicado en 2010

Autoxidation of ubiquinol-6 is independent of superoxide dismutase

scientific article published on 01 May 1996

Calpain activation in Huntington's disease.

artículo científico publicado en 2002

Calpain-1 cleaves and activates caspase-7.

artículo científico publicado en 2009

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

artículo científico publicado en 1998

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

artículo científico publicado en 2002

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

artículo científico publicado en 2012

Cell death mechanisms in ALS.

artículo científico publicado en 1996

Characterization and application of fluidic properties of trinucleotide repeat sequences by wax-on-plastic microfluidics

scientific article published on 02 January 2020

Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

artículo científico publicado en 2010

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

artículo científico publicado en 1999

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

artículo científico publicado en 2001

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

artículo científico publicado en 2002

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

artículo científico publicado en 2015

Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation

artículo científico publicado en 2000

Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis? ⬇️

artículo científico publicado el 1 de agosto de 1997

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue

artículo científico publicado en 2001

Effect of overexpression of Bcl-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome ⬇️

artículo científico publicado el 15 de diciembre de 2001

Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases ⬇️

artículo científico publicado el 15 de agosto de 1997

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

artículo científico publicado en 2005

FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase

artículo científico publicado en 2020

GENOMIC ANALYSIS OF HUMAN ISOGENIC APOE IPSC-DERIVED INHIBITORY GABAERGIC NEURONS

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells

artículo científico publicado en 2012

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells

artículo científico publicado en 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model

artículo científico publicado en 2013

Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast

artículo científico publicado en 1997

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

artículo científico publicado en 2007

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

artículo científico publicado en 2006

Huntingtin proteolysis in Huntington disease

IGF-1: elixir for motor neuron diseases

artículo científico publicado en 2009

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models ⬇️

artículo científico publicado el 24 de noviembre de 2010

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

artículo científico publicado en 2005

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

artículo científico publicado en 2000

Inhibition of Lipid Signaling Enzyme Diacylglycerol Kinase ϵ Attenuates Mutant Huntingtin Toxicity ⬇️

artículo científico publicado el 16 de abril de 2012

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

scientific journal article

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

scientific article published on 08 July 2020

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo

artículo científico publicado en 2015

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

artículo científico publicado en 2017

Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

artículo científico publicado en 2003

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

artículo científico publicado en 1999

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

artículo científico publicado en 1998

Loss of oxidation-reduction specificity in amyotrophic lateral sclerosis-associated CuZnSOD mutants

artículo científico publicado en 2000

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

artículo científico publicado en 2000

Mass spectrometric identification of novel lysine acetylation sites in huntingtin

artículo científico publicado en 2011

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease ⬇️

artículo científico publicado el 29 de julio de 2010

Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice

artículo científico publicado en 2007

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

artículo científico publicado en 2006

Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells

scientific article published on 01 October 2019

Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels

artículo científico publicado en 2021

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

artículo científico publicado en 2019

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein

artículo científico publicado en 1996

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties

artículo científico publicado en 2021

Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia

artículo científico publicado en 2006

Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor

scientific article published on 01 December 2000

Novel probes for label-free detection of neurodegenerative GGGGCC repeats associated with amyotrophic lateral sclerosis

scientific article published on 21 August 2019

Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling

artículo científico publicado en 2019

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

scientific journal article

Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease ⬇️

artículo científico publicado el 1 de enero de 2012

Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System

artículo científico publicado en 2014

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk

artículo científico publicado en 2009

Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease

artículo científico publicado en 2022

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment

artículo científico publicado en 2009

Pro-caspase-3 is a major physiologic target of caspase-8.

artículo científico publicado en 1998

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

artículo científico publicado en 2005

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

artículo científico publicado en 2010

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation

artículo científico publicado en 2007

Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction

artículo científico publicado en 2015

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease

artículo científico publicado en 2019

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

artículo científico publicado en 1999

Repeat Expansion Disorders: Mechanisms and Therapeutics

artículo científico publicado en 2019

Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

artículo científico publicado en 2012

Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2.

artículo científico publicado en 1996

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

artículo científico publicado en 2004

Structural evaluation of a novel pro-apoptotic peptide coupled to CNGRC tumor homing sequence by NMR.

artículo científico publicado en 2006

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase

artículo científico publicado en 1993

[Cellular mechanisms of protein quality control]

scientific article published on 01 November 2006

iPSC-based drug screening for Huntington's disease

artículo científico

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