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A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients

artículo científico publicado en 2015

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4.

artículo científico publicado en 2009

Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability

scientific article published on 19 August 2019

Age-related changes in the pharmacokinetic disposition of diazepam in foals

artículo científico publicado el 1 de agosto de 1997

Anaesthesia and central nervous system disease in small animals. Part I: General considerations

artículo científico

Anaesthesia and central nervous system disease in small animals. Part II: Anaesthetic management for specific diseases and procedures

artículo científico

Anaesthesia for small animal patients with disease of the hepatic, renal or gastrointestinal system

artículo científico

Anaesthesia for small animal patients with neuromuscular disease.

artículo científico publicado en 1990

Anaesthetic management of small animal patients with endocrine disease

artículo científico publicado en 1988

Anaesthetic management of the traumatized small animal patient

artículo científico publicado en 1989

Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases

artículo científico publicado en 2011

Biochemical Basis for Deficient Paracetamol Glucuronidation in Cats: an Interspecies Comparison of Enzyme Constraint in Liver Microsomes ⬇️

artículo científico publicado el 1 de abril de 1997

Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species

artículo científico publicado en 1997

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

artículo científico publicado en 2016

CYP2B6 (c.516G→T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients

scientific article published on April 2009

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

artículo científico publicado en 2000

CYP2B6(C.516G>T)and CYP2A6(*9B and *17) polymorphisms are independent preictors of efavirenz plasma concentrations in HIV -infected patients,

artículo científico

CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients

artículo científico publicado en 2009

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure

artículo científico publicado en 2013

Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding

scientific article published on 03 September 2019

Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding

artículo científico publicado en 2020

Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics

artículo científico

Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes

artículo científico publicado en 2016

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

artículo científico publicado en 2000

Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2.

artículo científico publicado en 2015

Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor

artículo científico publicado en 2008

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

artículo científico publicado en 2001

Development and validation of an ultrafast chromatographic method for quantification of the immunosuppressant mycophenolic acid in canine, feline and human plasma

artículo científico publicado en 2016

Diabetes Mellitus Reduces Activity of Human UDP-Glucuronosyltransferase 2B7 in Liver and Kidney Leading to Decreased Formation of Mycophenolic Acid Acyl-Glucuronide Metabolite ⬇️

artículo científico publicado el 1 de diciembre de 2010

Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10.

artículo científico publicado en 2008

Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old

artículo científico publicado en 2019

Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.

artículo científico publicado en 2017

Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers

artículo científico publicado en 2013

Effect of age on in vitro triazolam biotransformation in male human liver microsomes

artículo científico publicado en 2003

Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers

artículo científico publicado en 2013

Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats

artículo científico publicado en 2004

Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir

artículo científico publicado en 2006

Effect of midazolam infusion and flumazenil administration on epinephrine arrhythmogenicity in dogs anesthetized with halothane

artículo científico publicado en 1993

Effect of rifampin/isoniazid-containing antituberculosis therapy on efavirenz pharmacokinetics in HIV-infected children aged 3 to 14 years old

article

Effects of dietary soy isoflavones on health, steroidogenesis, and thyroid gland function in dogs

artículo científico publicado en 2009

Equine post-anesthetic lameness. A retrospective study

artículo científico publicado en 1990

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

artículo científico publicado en 2003

Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6.

artículo científico publicado en 2004

Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion

artículo científico publicado en 2009

Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences

artículo científico publicado en 2000

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

artículo científico publicado en 2013

Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone

artículo científico publicado en 2018

Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance

artículo científico publicado en 2014

Factors influencing midazolam hydroxylation activity in human liver microsomes

artículo científico publicado en 2006

Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen

artículo científico publicado en 2015

General anaesthesia for small animal patients with respiratory insufficiency.

artículo científico publicado en 1987

Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation

article

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo

artículo científico publicado en 2005

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases

artículo científico publicado en 2009

Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3

artículo científico publicado en 2009

Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity

artículo científico publicado en 2006

Identification and concentration of soy phytoestrogens in commercial dog foods

artículo científico publicado en 2004

Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach

artículo científico publicado en 2017

Identification and validation of the microRNA response elements in the 3'-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach.

artículo científico publicado en 2017

Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes

artículo científico publicado en 2018

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

artículo científico publicado en 2004

Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism

artículo científico publicado en 2010

In vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes.

artículo científico publicado en 2009

Influence of vaporizer setting on mask induction of dogs with isoflurane using an in-circuit vaporizer

artículo científico publicado en 1996

Inhalation therapy. Oxygen administration, humidification, and aerosol therapy

artículo científico publicado en 1985

Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

scientific article published on 01 April 1995

Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase

artículo científico publicado en 2009

Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

artículo científico publicado en 2007

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

artículo científico publicado en 2001

Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation

artículo científico publicado en 2009

Interstitial pH and pressure in the dependent biceps femoris muscle of laterally recumbent anesthetized horses.

artículo científico publicado en 1988

Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the horse

scientific article published on 01 February 1987

Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.

artículo científico publicado en 2014

Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor

artículo científico publicado en 2004

Measurement of muscle surface capillary blood flow by laser Doppler flowmetry

artículo científico publicado el 1 de noviembre de 1992

Mechanism of cytochrome P450-3A inhibition by ketoconazole ⬇️

artículo científico publicado el 1 de febrero de 2011

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

artículo científico publicado en 2000

Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers

artículo científico publicado en 2011

Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes

scientific article published on 01 April 1997

Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms

artículo científico publicado en 2000

Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

artículo científico publicado en 2007

Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

artículo científico publicado en 2008

Oral co-administration of fluconazole with tramadol markedly increases plasma and urine concentrations of tramadol and the O-desmethyltramadol metabolite (M1) in healthy dogs

artículo científico publicado en 2018

Paradoxically elevated efavirenz concentrations in HIV/tuberculosis- coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy

artículo científico publicado en 2011

Personalized medicine: going to the dogs?

scientific article published on 28 April 2019

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

artículo científico publicado en 2004

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization

scientific article published on 09 January 2020

Pharmacokinetics and milk residues of butorphanol in dairy cows after single intravenous administration

artículo científico publicado el 1 de marzo de 1992

Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs

artículo científico publicado en 1992

Pharmacokinetics of a Sustained-release Formulation of Meloxicam After Subcutaneous Administration to Hispaniolan Amazon Parrots (Amazona ventralis).

artículo científico publicado en 2017

Pharmacokinetics of dantrolene sodium in horses

artículo científico publicado en 1987

Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: Pharmacogenetic effect of CYP2B6 variation

artículo científico publicado en 2008

Pharmacokinetics of meloxicam after intravenous, intramuscular, and oral administration of a single dose to Hispaniolan Amazon parrots (Amazona ventralis)

artículo científico publicado en 2013

Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats

artículo científico publicado en 2004

Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α).

artículo científico publicado en 2015

Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results

artículo científico publicado en 2012

Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice

artículo científico publicado en 2007

Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems

artículo científico publicado en 2018

Postanesthetic hind limb adductor myopathy in five horses.

artículo científico publicado en 1988

Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences

artículo científico publicado en 1999

Quantitation of CYP2B6, Constitutive Androstane Receptor, and Pregnane X Receptor mRNA levels ⬇️

artículo científico publicado el 1 de mayo de 2003

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues.

artículo científico publicado en 2011

Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers

artículo científico publicado en 2017

Recommended techniques in small animal anaesthesia. II. Intraoperative cardiac dysrhythmias and their treatment

artículo científico publicado en 1987

Recommended techniques in small animal anaesthesia. IV. Anaesthesia and cardiac disease

artículo científico publicado en 1988

Recommended techniques in small animal anaesthesia: an update.

artículo científico publicado en 1984

Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs

artículo científico publicado en 2017

Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers

artículo científico publicado en 2006

Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.

artículo científico publicado en 2010

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

scientific article published on 28 March 2007

Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes

artículo científico publicado en 2008

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity

artículo científico publicado en 2005

Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes

artículo científico publicado en 2014

Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences

artículo científico publicado en 2003

Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem

artículo científico publicado en 2009

Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus ⬇️

artículo científico publicado el 1 de julio de 2011

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

artículo científico publicado en 2002

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

scientific article published on 04 April 2006

The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-

artículo científico publicado en 2013

The clinical pharmacology of agents used to manage cardiovascular instability during general anaesthesia in small animals.

artículo científico publicado en 1988

Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs).

artículo científico publicado en 2016

Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

artículo científico publicado en 2016

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

artículo científico publicado en 2005

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

artículo científico publicado en 2005

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

artículo científico publicado en 2004

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

artículo científico publicado en 2005

Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes

artículo científico publicado en 2005

Use of a narcotic antagonist (nalmefene) to suppress self-mutilative behavior in a stallion

artículo científico publicado el 1 de junio de 1988

Use of narcotic antagonists to modify stereotypic self-licking, self-chewing, and scratching behavior in dogs

artículo científico publicado en 1988

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

artículo científico publicado en 2003

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