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3‐Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor‐initiating hepatocellular carcinoma cells ⬇️

artículo científico publicado el 20 de agosto de 2011

A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.

artículo científico publicado en 2017

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1

scientific journal article

Aging and Clonal Behavior of Hematopoietic Stem Cells

artículo científico publicado en 2022

Aging and leukemic evolution of hematopoietic stem cells under various stress conditions

scientific article published on 05 November 2020

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation

artículo científico publicado en 2019

Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma

scientific article published on 22 October 2019

Aldehyde dehydrogenase 1 is associated with recurrence‐free survival but not stem cell‐like properties in hepatocellular carcinoma ⬇️

artículo científico publicado el 14 de mayo de 2012

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

artículo científico publicado en 2015

Antiproliferative action of metformin in human lung cancer cell lines ⬇️

artículo científico publicado el 18 de abril de 2012

Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

scientific article published on 28 August 2019

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

scientific article published on 18 September 2018

Biological features and biomarkers in hepatocellular carcinoma

artículo científico publicado en 2015

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription

artículo científico publicado en 2017

Bmi1 confers resistance to oxidative stress on hematopoietic stem cells

artículo científico publicado en 2012

Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing

artículo científico publicado en 2006

Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature

artículo científico publicado en 2019

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

artículo científico publicado en 2010

Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

scientific journal article

Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche

artículo científico publicado en 2019

CD244 expression represents functional decline of murine hematopoietic stem cells after culture

Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective

artículo científico publicado en 2009

Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology

artículo científico

Circulating cancer stem cells: a novel prognostic predictor of hepatocellular carcinoma

artículo científico publicado en 2013

Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias ⬇️

artículo científico publicado el 29 de junio de 2012

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils

artículo científico publicado en 2021

Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice

artículo científico publicado en 2012

Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice

scientific article published on 08 June 2015

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

artículo científico publicado en 2013

Consequence of the loss of Sox2 in the developing brain of the mouse

artículo científico publicado en 2008

Cytokine signaling, lipid raft clustering, and HSC hibernation

artículo científico publicado en 2007

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

artículo científico publicado en 2006

DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes

artículo científico publicado en 2021

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

artículo científico publicado en 2011

Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells

artículo científico publicado en 2010

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

artículo científico publicado en 2014

Deregulated Polycomb functions in myeloproliferative neoplasms

scientific article published on 31 January 2019

Deregulated polycomb complex function in the pathogenesis of MDS.

artículo científico publicado en 2017

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

artículo científico publicado en 2006

Diploid, not polyploid: new platelet producers

artículo científico publicado en 2014

Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.

artículo científico publicado en 2011

Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma

artículo científico publicado en 2009

Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners

scientific article published on 13 January 2014

Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process

artículo científico publicado en 2009

Downregulation of rRNA transcription triggers cell differentiation

artículo científico publicado en 2014

Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation

artículo científico publicado en 2016

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

artículo científico publicado en 2017

Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line

scientific article published on 03 October 2013

Efficacy of the Novel Tubulin Polymerization Inhibitor PTC-028 for Myelodysplastic Syndrome

artículo científico publicado en 2020

Emerging role of noncanonical polycomb repressive complexes in normal and malignant hematopoiesis

artículo científico publicado en 2018

Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development

artículo científico publicado en 2005

Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation

artículo científico publicado en 2007

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

artículo científico publicado en 2004

Epigenetic dysregulation in hematological malignancies

artículo científico publicado en 2016

Epigenetic regulation of hematopoiesis

artículo científico publicado en 2012

Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes.

artículo científico publicado en 2005

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

artículo científico publicado en 2022

Epigenetics of hematopoietic stem cell aging and disease

artículo científico

Epigenome in hematopoietic malignancies

artículo científico publicado el 1 de octubre de 2011

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis

artículo científico publicado en 2002

Essential and instructive roles of GATA factors in eosinophil development

artículo científico publicado en 2002

Ex Vivo Expansion of Human Hematopoietic Stem Cells by Garcinol, a Potent Inhibitor of Histone Acetyltransferase ⬇️

artículo científico publicado el 12 de septiembre de 2011

Ex vivo expansion of human cord blood hematopoietic stem cells using small-molecule compounds

artículo científico publicado en 2015

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.

artículo científico publicado en 2009

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

article

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

artículo científico publicado en 2012

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

artículo científico publicado en 2015

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

artículo científico publicado en 2014

Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation

scientific article published on 06 August 2018

Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells

artículo científico publicado en 2016

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells

artículo científico publicado en 2010

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.

artículo científico publicado en 2015

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

artículo científico publicado en 2008

Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

artículo científico publicado en 2021

Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells

artículo científico publicado en 2011

Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation

scientific article published on 11 September 2018

GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition

artículo científico publicado en 2018

Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms

artículo científico publicado en 2015

Genetic and transcriptional landscape of plasma cells in POEMS syndrome

scientific article published on 11 January 2019

Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain

scientific journal article

Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

artículo científico publicado en 2019

Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

artículo científico publicado en 2011

Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

artículo científico publicado en 2002

Guest editorial: Epigenetics of hematopoiesis and hematological malignancies ⬇️

artículo científico publicado el 27 de septiembre de 2012

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity

artículo científico publicado en 2017

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.

artículo científico publicado en 2015

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.

artículo científico publicado en 2018

Hematopoietic stem cell aging and hematopoietic malignancies

artículo científico publicado en 2016

High levels of morphological variation despite close genetic relatedness between Zoanthus aff. vietnamensis and Zoanthus kuroshio (Anthozoa: Hexacorallia).

artículo científico publicado en 2006

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

artículo científico publicado en 2014

Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma

artículo científico publicado en 2017

Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma

artículo científico publicado en 2014

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

scientific article published on 14 June 2017

Identification and investigation of methylated genes in hepatoma

artículo científico publicado en 2005

Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata.

artículo científico publicado en 2017

Identification of Transcripts Commonly Expressed in Both Hematopoietic and Germ-Line Stem Cells

scientific article published on 01 February 2008

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model

artículo científico publicado en 2016

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

artículo científico publicado en 2017

KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis

scientific article published on 01 September 2019

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes

artículo científico publicado en 2012

Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction

artículo científico publicado en 2016

Life and death in hematopoietic stem cells.

artículo científico publicado en 2007

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

artículo científico publicado en 2021

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

article

Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells

artículo científico publicado en 2016

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

artículo científico publicado en 2014

MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19(cdkn2a).

artículo científico publicado en 2015

MOZ is essential for maintenance of hematopoietic stem cells

scientific journal article

Manipulation of hematopoietic stem cells for regenerative medicine

artículo científico publicado en 2013

Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo

artículo científico publicado en 2007

Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells ⬇️

artículo científico publicado el 29 de julio de 2013

MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1.

artículo científico publicado en 2009

Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status

artículo científico publicado en 2020

Morphological and molecular revision of Zoanthus (Anthozoa: Hexacorallia) from southwestern Japan, with descriptions of two new species

artículo científico publicado en 2006

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies

artículo científico publicado en 2016

Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice

artículo científico publicado en 2014

NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis

scientific article published on 01 April 2019

New approaches to expand hematopoietic stem and progenitor cells ⬇️

artículo científico publicado el 23 de abril de 2012

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice

artículo científico publicado en 2015

Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche

artículo científico publicado en 2011

Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway.

artículo científico publicado en 2014

Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study

artículo científico publicado en 2020

Nuclear, not cytoplasmic, PKR maneuvers in AML.

artículo científico publicado en 2015

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

artículo científico publicado en 2021

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

artículo científico publicado en 2005

Overexpression of RUNX3 represses RUNX1 to drive transformation of myelodysplastic syndrome

scientific article published on 27 April 2020

PLZF limits enhancer activity during hematopoietic progenitor aging

scientific article published on 01 May 2019

PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome

artículo científico publicado en 2020

Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation

scientific journal article

Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy

artículo científico publicado en 2005

Pathogenic Impacts of Dysregulated Polycomb Repressive Complex Function in Hematological Malignancies

artículo científico publicado en 2020

Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis

scientific article published on 07 May 2020

Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

artículo científico publicado en 2010

Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells ⬇️

artículo científico publicado el 14 de marzo de 2011

Polycomb repressive complexes in hematological malignancies

artículo científico publicado en 2017

Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.

artículo científico publicado en 2016

Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway.

artículo científico publicado en 2017

Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation.

artículo científico publicado en 2016

Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.

artículo científico publicado en 2006

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes

artículo científico publicado en 2013

Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment

artículo científico publicado en 2002

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.

artículo científico publicado en 2017

Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus

artículo científico publicado en 2017

Retroviral expression screening of oncogenes in natural killer cell leukemia

artículo científico publicado en 2005

Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells ⬇️

artículo científico publicado el 1 de junio de 2003

Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia

artículo científico publicado en 2004

Role of SOX17 in hematopoietic development from human embryonic stem cells

artículo científico publicado en 2012

Role of the polycomb group proteins in hematopoietic stem cells

artículo científico publicado en 2010

Role of the polycomb group proteins in the restriction of tumor development in hematological malignancies

artículo científico publicado el 1 de julio de 2013

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

artículo científico publicado en 2005

Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition

artículo científico publicado en 2014

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

artículo científico publicado en 2016

Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties

artículo científico publicado en 2006

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

artículo científico publicado en 2005

Sox17 as a candidate regulator of myeloid restricted differentiation potential

artículo científico publicado en 2014

Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos

artículo científico publicado en 2020

Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters

artículo científico publicado en 2014

Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint

artículo científico publicado en 2014

Structure and function of MYST family histone acetyltransferases

artículo científico publicado el 1 de julio de 2011

Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells

scientific article published on 05 September 2019

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

artículo científico publicado en 2008

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

artículo científico

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.

artículo científico publicado en 2011

The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells.

artículo científico publicado en 2004

The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon

artículo científico publicado en 2006

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells

artículo científico publicado en 2014

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

scientific article published on 27 March 2019

The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.

artículo científico publicado en 2005

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.

artículo científico publicado en 2016

The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass

scientific article published on 28 March 2017

The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma

scientific article published on 01 October 2008

The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

artículo científico publicado en 2010

Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing

artículo científico publicado en 2008

Transcriptional regulation of spermatogonial stem cell self-renewal

artículo científico publicado en 2007

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

artículo científico publicado en 2009

Tumor suppressor function of the polycomb group genes.

artículo científico publicado en 2012

UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes

artículo científico publicado en 2020

Unique composition of polycomb repressive complex 1 in hematopoietic stem cells

artículo científico publicado en 2007

YAP/TAZ Promote Hematopoietic Regeneration Via Accelerating the Recovery of Bone Marrow Niche

artículo científico publicado en 2021

[Dyserythropoiesis in myelodysplastic syndrome]

artículo científico publicado en 2018

[Epigenetic dysregulation in myelodysplastic syndrome]

scientific article published on 01 February 2015

[Function of role of polycomb group complexes and possibility of novel molecular target in cancer]

scientific article published on 01 August 2010

[Ineffective erythropoiesis in myelodysplastic syndrome]

artículo científico publicado en 2018

[Mutations of epigenetic regulator genes and myeloid malignancies]

artículo científico publicado en 2015

[Overview]

artículo científico publicado en 2015

[Self-renewal mechanisms of leukemic stem cells]

scientific article published on 01 July 2008

[The cancer stem cell model in hematological malignancies]

artículo científico publicado en 2015

pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1

scientific journal article

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