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(18)F-Labeled benzylideneaniline derivatives as new ligands for beta-amyloid plaque imaging in Alzheimer's disease

artículo científico publicado en 2009

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling ⬇️

artículo científico publicado el 27 de junio de 2012

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

scientific article published on 27 June 2019

A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells

artículo científico publicado en 2015

A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques

scientific article published on 07 April 2016

A relationship between Alzheimer's disease and type 2 diabetes mellitus through the measurement of serum amyloid-beta autoantibodies

artículo científico publicado en 2010

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

artículo científico publicado en 2012

Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells

artículo científico publicado en 2009

Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models

scientific article published on 25 November 2019

Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation

artículo científico publicado en 2015

Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes

scientific article published on March 2014

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway ⬇️

artículo científico publicado el 24 de julio de 2012

Altered free amino acid levels in brain cortex tissues of mice with Alzheimer's disease as their N(O,S)-ethoxycarbonyl/tert-butyldimethylsilyl derivatives

artículo científico publicado en 2008

Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.

artículo científico publicado en 2013

Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation

artículo científico publicado en 2008

Amyloid beta peptide directly inhibits PKC activation

artículo científico publicado en 2004

Amyloid beta regulates ER exit sites formation through O-GlcNAcylation triggered by disrupted calcium homeostasis

scientific article published on 03 September 2020

Amyloid beta-mediated epigenetic alteration of insulin-like growth factor binding protein 3 controls cell survival in Alzheimer's disease

artículo científico publicado en 2014

Amyloid peptide attenuates the proteasome activity in neuronal cells

artículo científico publicado en 2005

Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes

artículo científico publicado en 2002

Amyloid β-induced elevation of O-GlcNAcylated c-Fos promotes neuronal cell death

artículo científico publicado en 2018

Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets

artículo científico

Annexin A1 restores Aβ1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway

artículo científico publicado en 2016

Astrocyte-Originated ATP Protects Aβ1-42-Induced Impairment of Synaptic Plasticity ⬇️

artículo científico publicado el 29 de febrero de 2012

Autophagy-Mediated Secretory Pathway is Responsible for Both Normal and Pathological Tau in Neurons

artículo científico publicado en 2019

Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals

artículo científico publicado el 27 de julio de 2012

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer's disease

artículo científico publicado en 2015

Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling ⬇️

artículo científico publicado el 1 de noviembre de 2011

BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis

artículo científico publicado en 2008

Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation

artículo científico publicado en 2006

Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals

artículo científico publicado en 2018

Both targeted mass spectrometry and flow sorting analysis methods detected the decreased serum apolipoprotein E level in Alzheimer's disease patients

artículo científico publicado en 2013

Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation

artículo científico publicado en 2019

Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators

artículo científico publicado en 2006

Cell-based assay for β-secretase activity ⬇️

artículo científico publicado el 1 de diciembre de 2003

Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

artículo científico publicado en 2017

Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer's Disease in Mice, Observed by in Vivo Two-Photon Imaging

artículo científico publicado en 2016

Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons

artículo científico publicado en 2009

Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis.

artículo científico publicado en 2003

Contributions of microglia to structural synaptic plasticity

artículo científico publicado en 2013

Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

artículo científico publicado en 2013

Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease

artículo científico publicado en 2014

Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway

artículo científico publicado en 2017

Cytosolic amyloid-beta peptide 42 escaping from degradation induces cell death

artículo científico publicado en 2006

DMC (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone) improves glucose tolerance as a potent AMPK activator.

artículo científico publicado en 2015

Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease

scientific article published on 15 November 2019

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

artículo científico publicado en 2016

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling

artículo científico publicado en 2007

Disruption of blood-brain barrier in Alzheimer disease pathogenesis

artículo científico publicado en 2013

Diverse molecular targets for therapeutic strategies in Alzheimer's disease

artículo científico publicado en 2014

ERK1/2 is an endogenous negative regulator of the gamma-secretase activity

artículo científico publicado en 2005

Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease ⬇️

artículo científico publicado el 14 de diciembre de 2012

Effect of ischemic neuronal insults on amyloid precursor protein processing

artículo científico publicado en 2006

Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles ⬇️

artículo científico publicado el 15 de diciembre de 2010

Effects of Chronic Tinnitus on Metabolic and Structural Changes in Subjects With Mild Cognitive Impairment

artículo científico publicado en 2020

Electroacupuncture Enhances Motor Recovery Performance with Brain-Derived Neurotrophic Factor Expression in Rats with Cerebral Infarction ⬇️

artículo científico publicado el 23 de junio de 2012

Furin is an endogenous regulator of alpha-secretase associated APP processing

artículo científico publicado en 2006

Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ 1-42 oligomer injection

artículo científico

Genetic associations of in vivo pathology influence Alzheimer's disease susceptibility

artículo científico publicado en 2020

Ghrelin Ameliorates Cognitive Dysfunction and Neurodegeneration in Intrahippocampal Amyloid-β1-42 Oligomer-Injected Mice ⬇️

artículo científico publicado el 1 de enero de 2011

Global changes of phospholipids identified by MALDI imaging mass spectrometry in a mouse model of Alzheimer's disease

artículo científico publicado en 2015

HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons ⬇️

artículo científico publicado el 22 de agosto de 2012

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

artículo científico publicado en 2016

Harnessing Intramolecular Rotation To Enhance Two-photon Imaging of Aβ Plaques through Minimizing Background Fluorescence

scientific article published on 20 March 2019

Hearing loss as a risk factor for cognitive impairment and loss of synapses in the hippocampus

scientific article published on 02 July 2019

Human serum transthyretin levels correlate inversely with Alzheimer's disease

artículo científico publicado en 2011

IFN-gamma-induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes

artículo científico publicado en 2007

Identification of autoantibody against beta-amyloid peptide in the serum of elderly

artículo científico publicado en 2009

Impaired Short-Term Plasticity in Mossy Fiber Synapses Caused by Mitochondrial Dysfunction of Dentate Granule Cells Is the Earliest Synaptic Deficit in a Mouse Model of Alzheimer's Disease ⬇️

artículo científico publicado el 25 de abril de 2012

Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice

artículo científico

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

artículo científico publicado en 2017

Induction of homosynaptic long-term depression in entorhinal cortex

artículo científico publicado en 2002

Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease

artículo científico publicado en 2012

Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure

artículo científico publicado en 2004

Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-β exposure

artículo científico publicado en 2004

Inhibition of Cholesterol Biosynthesis Reduces γ-Secretase Activity and Amyloid-β Generation

artículo científico publicado en 2016

Inhibition of glutaminyl cyclase ameliorates amyloid pathology in an animal model of Alzheimer's disease via the modulation of γ-secretase activity.

artículo científico

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.

artículo científico publicado en 2016

Intracellular Amyloid-β Accumulation in Calcium-Binding Protein-Deficient Neurons Leads to Amyloid-β Plaque Formation in Animal Model of Alzheimer's Disease ⬇️

artículo científico publicado el 1 de enero de 2012

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice

artículo científico publicado en 2014

Intrahippocampal injection of a lentiviral vector expressing neurogranin enhances cognitive function in 5XFAD mice

artículo científico publicado en 2018

Knock-down of protein L-isoaspartyl O-methyltransferase increases β-amyloid production by decreasing ADAM10 and ADAM17 levels

scientific article published on March 2011

Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics

artículo científico publicado en 2017

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

artículo científico publicado en 2015

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

artículo científico publicado en 2003

Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study

artículo científico publicado en 2017

Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

artículo científico

MicroRNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum.

artículo científico publicado en 2015

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model

artículo científico publicado en 2016

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

artículo científico publicado en 2014

Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil

scientific article published on 25 September 2019

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death ⬇️

artículo científico publicado el 13 de abril de 2012

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease

artículo científico publicado en 2016

Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.

artículo científico publicado en 2015

Mitochondrial abnormalities related to the dysfunction of circulating endothelial colony-forming cells in moyamoya disease

artículo científico publicado en 2017

Mitochondrial dysfunction and calcium deregulation by the RanBP9‐cofilin pathway ⬇️

artículo científico publicado el 27 de agosto de 2013

Modulation of mitochondrial function by stem cell-derived cellular components.

artículo científico publicado en 2014

Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics

artículo científico publicado en 2018

Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

artículo científico publicado en 2004

Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis ⬇️

artículo científico publicado en 2002

New Microglia on the Block

scientific article published on 01 April 2020

Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model

scientific article published on 04 December 2018

O-GlcNAcylation regulates endoplasmic reticulum exit sites through Sec31A modification in conventional secretory pathway

artículo científico publicado en 2018

O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation

scientific journal article

O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment

artículo científico publicado en 2012

PRAK mediates Aβ-RAGE driven autophagy pathway

artículo científico publicado en 2017

Performance of the QPLEX™ Alz plus assay, a novel multiplex kit for screening cerebral amyloid deposition

scientific article published on 06 January 2021

Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review

artículo científico publicado en 2020

Phosphokinase antibody arrays on dendron-coated surface.

artículo científico publicado en 2014

PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease

artículo científico publicado en 2016

Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease

scientific article published on 01 March 2019

Profiling proteins related to amyloid deposited brain of Tg2576 mice

artículo científico publicado en 2004

Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease

artículo científico publicado en 2019

Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease

artículo científico publicado en 2016

Quantitative proteomic analysis of the hippocampus in the 5XFAD mouse model at early stages of Alzheimer's disease pathology.

artículo científico

RAGE: the beneficial and deleterious effects by diverse mechanisms of actions

artículo científico publicado en 2011

RNA-Seq analysis of frontal cortex and cerebellum from 5XFAD mice at early stage of disease pathology

artículo científico

Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.

artículo científico publicado en 2008

Reduced serum level of antibodies against amyloid beta peptide is associated with aging in Tg2576 mice

artículo científico publicado en 2007

Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway

artículo científico publicado en 2017

Retraction of "β-Amyloid and α-Synuclein Cooperate To Block SNARE-Dependent Vesicle Fusion".

artículo científico publicado en 2017

Role for PKC-epsilon in neuronal death induced by oxidative stress

artículo científico

SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease

artículo científico publicado en 2017

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians

artículo científico publicado en 2013

Special issue on neurodegenerative diseases and their therapeutic approaches

artículo científico publicado en 2015

Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR

artículo científico publicado en 2018

Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

artículo científico publicado en 2015

Stepwise silver-staining-based immunosorbent assay for amyloid-beta autoantibody detection

artículo científico publicado en 2008

Structure–activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template ⬇️

artículo científico publicado el 17 de abril de 2013

Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes ⬇️

artículo científico publicado el 28 de junio de 2013

TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia

artículo científico publicado en 2017

The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer's disease pathogenesis

artículo científico publicado en 2016

The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer's disease

scientific article published on 01 December 2019

The role of mitochondrial DNA mutation on neurodegenerative diseases

artículo científico publicado en 2015

Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer's disease

artículo científico publicado en 2015

Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells

artículo científico publicado en 2018

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model

scientific article published on 30 August 2019

Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model

artículo científico publicado en 2005

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal

artículo científico

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

scientific journal article

Upregulation of amyloid precursor protein by platelet-derived growth factor in hippocampal precursor cells

artículo científico publicado en 2007

Variation in effective stimulus patterns for induction of long-term potentiation across different layers of rat entorhinal cortex.

artículo científico publicado en 2002

Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer's Disease.

artículo científico publicado en 2018

miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission

artículo científico publicado en 2020

p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

artículo científico publicado en 2016

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

artículo científico publicado en 2017

β-Amyloid and α-synuclein cooperate to block SNARE-dependent vesicle fusion

artículo científico publicado en 2015

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