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A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens

artículo científico publicado en 2024

Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane

scientific article published on 15 October 2020

Activation mechanism of the class D fungal GPCR dimer Ste2

artículo científico publicado en 2022

Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule

artículo científico publicado en 2018

Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism

artículo científico publicado en 2018

Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

artículo científico publicado en 2022

Efficient and Selective Electrochemically Driven Enzyme-Catalyzed Reduction of Carbon Dioxide to Formate using Formate Dehydrogenase and an Artificial Cofactor

artículo científico publicado en 2019

Engineering salt bridge networks between transmembrane helices confers thermostability in G-protein Coupled Receptors

artículo científico publicado en 2018

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

artículo científico publicado en 2020

Prediction of Conformation Specific Thermostabilizing Mutations for Class A G Protein-Coupled Receptors

artículo científico publicado en 2019

Structural basis of odorant recognition by a human odorant receptor ⬇️

Structure of the class D GPCR Ste2 dimer coupled to two G proteins

scientific article published on 02 December 2020

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